If we want to identify most common beta-thalassemia mutations (comprising beta zero thalassemias and beta plus) and the haemoglobin variants then we should use thalassemia-beta-globin-gene-sequencing. Dominant beta-thalassemia and hyper unstable haemoglobin variants as well as other haemoglobin variants (cannot be identified by protein methods) are identified by it. Thalassemia-Beta-Globin-Gene-Sequencing cannot detect some haemoglobin disorders such as crossover events and large deletional mutations. The interpretation of its result is done with the context of RBC indices and protein studies.
Thalassemia-Beta-Globin-Gene-Sequencing requires some sort of preparations. These preparations are discussed in the following manner.
• Thalassemia-Beta-Globin-Gene-Sequencing needs DNA sample. We should not touch the sample derived from the body of the patient.
• We should keep that sample in clean and hygienic conditions.
• We should ensure the fact that the lab where DNA is extracted from that sample functions effectively.
The utility of thalassemia-beta-gene-sequencing is at par. This utility can be discussed in the following manner.
• Beta thalassemia major or intermedia can be diagnosed by it.
• Specific beta thalassemia mutation can be identified by it
• Chronic haemolytic anaemia of unknown etiology can be evaluated by it.
• With left-shifted p50 oxygen dissociation results, the hereditary erythrocytosis can be evaluated by it.
• The disorder of beta haemoglobin (based on family history) is taken into consideration as a concern by following the method of preconception screening in it.
In the procedure of thalassemia-beta-globin-gene-sequencing, first of all, DNA sample is prepared. For preparing DNA sample, the sample is taken from cheek, hair or saliva. That sample is allowed to be divided into two parts. We have to extract DNA from that sample and have to purify it. We can detect common beta-thalassemia mutation in the DNA sample of Patient by sequencing technology (involve full gene sequencing for the reading the related genes).
| Type | Gender | Age-Group | Value |
|---|---|---|---|
|
Beta Thalassemia Globin Sequencing Gene Testing Blood
|
Unisex
|
All age groups
|
< 3.5%
|
1) Diabetes is curable :
Diabetes is mainly due deficiency of Insulin (hormone produced by Beta cells of pancreas), plus resistance to action of insulin, overweightor obesity and inactivity. Therefore, to treat diabetes we need drugs that initiate insulin secretion, reduce insulin resistance. In some cases insulin itself. Plus dietary control and regular exercise to maintain normal weight or reduce excess weight. Hence it can only be effectively controlled. Cure is not possible.
2) Eating Sugar or Sweets causes Diabetes :
It is incorrect to say that eating sweets and / or sugar causes diabetes. Basically excess food intake will lead to excess production of glucose. That puts excess load on insulin producing cells in pancreas due glucotoxicity. Also due to central obesity the fat around internal organs causes lipotoxicity affecting the beta cells. Therefore, excess food intake in general and weight gain are the reasons for diabetes.
3) Jaggery is better or safe in diabetes :
Jaggery and sugar both are essentially same. Both contain sucrose, as they are prepared from sugar cane juice. Hence eating either of these will increase blood glucose considerably. In jaggery there are some vitamins and a few antioxidants. But both are bad for a diabetic person.
4) Rice should not be eaten in diabetes :
Not really true. Because in south India this is the major or at times only main food. Rice has a high glycemic index so gets converted to glucose rapidly. So polished rice is not good. Brown rice is better. Quantity should be regulated. All other cereals also are converted glucose after digestion.
5)Allopathic Medications Damage Kidneys, so go for either Ayurvedic or Homeopathic Drugs :
In fact diabetes itself affects kidney, particularly the filtering membrane of glomerulurous (a filtering unit in the kidney). Even when diabetes fairly well controlled, kidney does get affected. The drugs used to treat diabetes help in overcoming kidney damage. Therefore it is wrong to think that modern drugs cause kidney damage. In fact some of the other drugs contain heavy metals (Bhasmas), which can be harmful to the kidney.
6) Sugar intake is essential for body :
Some people keep asking that eating sugar is very necessary for getting energy for the body tissues. This is not at all true. Because all the cereals like rice, jowar, wheat, ragi, bajra and other millets, contain starch as the main ingredient. Hence intake of each of these foods provides glucose after digestion. So there is no separate need for taking sugar.
Few things to be remembered and practiced are :
High blood pressure, also called hypertension, usually has no symptoms. But it can cause serious problems such as stroke, heart failure, heart attack and kidney failure. If you cannot control your high blood pressure through lifestyle changes such as losing weight and reducing sodium in your diet, you may need medicines.
Blood pressure medicines work in different ways to lower blood pressure. Some remove extra fluid and salt from the body. Others slow down the heartbeat or relax and widen blood vessels. Often, two or more medicines work better than one.
FDA has approved many medications to treat high blood pressure, including
Many people with high blood pressure may need more than one medication to reach their goal blood pressure. Your health care provider can tell you if you should be on medication and, if so, which drug(s) may be best for you.
If you have anemia, your blood does not carry enough oxygen to the rest of your body. The most common cause of anemia is not having enough iron. Your body needs iron to make hemoglobin. Hemoglobin is an iron-rich protein that gives the red color to blood. It carries oxygen from the lungs to the rest of the body.
Anemia has three main causes: blood loss, lack of red blood cell production, and high rates of red blood cell destruction.
Conditions that may lead to anemia include
Anemia can make you feel tired, cold, dizzy, and irritable. You may be short of breath or have a headache.
Your doctor will diagnose anemia with a physical exam and blood tests. Treatment depends on the kind of anemia you have.
5 super fruits that prevent hair fall
1. Strawberries: The benefits of this beautiful fruit are many so many that beauty and health enthusiasts can write an ode to the strawberry. This fruit comes loaded with silica a component that’s known to prevent baldness and aid hair growth.
2. Apples
Apple is filled with soluble fibre, phenolic compound in apple skin, antioxidants and vitamins, this fruit sings to your body and serenades your hair. So much so that if eaten regularly, it will prevent hair fall and benefit your overall health in many ways. When buying apples, be wary of the amount of wax on them.
3. Grapes
Grape seed oil is full of antioxidants, vitamins, natural sugars and a lot more, grapes clean out your system and prevent hair fall. One of the most delicious fruits that are high in water content, these little ovals of joy will do your crowning glory a world of good.
4. Bananas
This potassium-loaded fruit comes packed with vitamin b, magnesium, fibre, pectin and a host of other goodies that do nothing but enhance your overall health. And as if that’s not enough, this sunshine fruits ensures that your strands of hair maintain their thickness by preventing hair fall.
5. Oranges
Vitamin c – this fruits practically sings this vitamin. Besides the fabulous c, it’s loaded with antioxidants, flavonoids, beta-carotene, magnesium, fibre and a host of essential vitamins and minerals.
If you check the recent scientific studies, then you will come to know that PPI drugs are treated as the popular medicines to treat heartburn troubles, but as the side-effect, you will face acute cognitive troubles. Your mental condition might get affected in various ways causing memory or concentration loss, decrease in brain ability and others. Though, these drugs are very safe but only effectively treating heartburn troubles, especially gastroesophageal-reflux disease.
How Dementia is related with PPI drugs?
PPI drugs are normally recommended by doctors for treating heartburn issues, but if you are taking these drugs on a continuous basis, then you might face the unwanted signs or symptoms of dementia. This is a hardcore fact, and it has been observed by many reputed researchers of the present age. There are some commonest symptoms that can be observed due to dementia, and some of the prominent ones are as follows:-
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