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Overview

Treponema Pallidium Antobody Test

Treponema Pallidium Antobody Test

also known as: MHA-TP , Syphilis

Syphilis test is used to screen for and/or diagnose infection with Treponema pallidum, the bacterium that causes Syphilis. The antibody test detects the antibodies in the blood and also in the cerebrospinal fluid (CSF). There are two general types of tests available for syphilis test, non treponemal antibody, and treponemal test. Either of these tests is used to detect active syphilis. The nontreponemal test is highly sensitive but since it is nonspecific, false-positive test results can be caused due to pregnancy, Lyme disease, malaria, tuberculosis, or other autoimmune disorder. Treponemal antibody test is highly specific for syphilis which can detect for active syphilis. The symptoms of this infection are skin rash often on the palms of the hands and bottom of the feet which do not cause itching, sore throat and body aches.

No special information is required while going for the test. You need to inform the doctor about all the medicines that you take so that the doctor can advise against it till the test if any of the medicines can alter the results of the test.

A negative blood test means that it is possible that the infection is not present. However, it means that only at that time there is no evidence of the disease. Antibodies may be detected after several weeks after the exposure to the bacteria. So if the patients have familiar symptoms, they should get tested again.

A band is wrapped around the arm, preferably near the elbow pit such that vein is clearly seen The area is cleaned with 70% alcohol The needle is inserted into the visible vein causing a small prick and the required amount of blood sample is collected The collected blood is transferred into the blood container from the nozzle and the syringe is hygienically disposed immediately

Specimen
Serum
Volume
1 mL
Container
Red-top tube or gel-barrier tube.
Type Gender Age-Group Value
Treponema Pallidum Antibodies
Unisex
All age groups
Detected in positive cases
Average price range of the test is between Rs.600 to Rs.1200 depending on the factors of city, quality and availablity.

Table of Content

What is Treponema Pallidium Antobody Test?
Preparation for Treponema Pallidium Antobody Test
Uses of Treponema Pallidium Antobody Test
Procedure for Treponema Pallidium Antobody Test
Specimen Requirements
Normal values for Treponema Pallidium Antobody Test
Price for Treponema Pallidium Antobody Test
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Popular Questions & Answers

Dear Sir, VDRL showing non reactive and TPHA showing week positive. What does it mean and how I can cure or make my tpha negative. Please give the details how I can cure soon as possible as I have to go abroad if only after qualify the medical test.

C.S.C, D.C.H, M.B.B.S
General Physician, Alappuzha
Dear Sir, VDRL showing non reactive and TPHA showing week positive. What does it mean and how I can cure or make my t...
A similar specific treponemal test for syphilis is the Treponema pallidum hemagglutination assay or TPHA. TPHA is an indirect hemagglutination assay used for the detection and titration of antibodies against the causative agent of syphilis, Treponema pallidum subspecies pallidum. The VDRL test is a screening test for syphilis. It measures substances, called antibodies, that your body may produce if you have come in contact with the bacteria that causes syphilis. This bacteria is called Treponema pallidum. The test is similar to the newer rapid plasma reagin (RPR) test.

What is the meaning of tpha positive Treponema pallidum haemagglutination ? Please explain in hindi. My husband is tpha positive. And tell treatment also.

MD - Social & Preventive Medicine / Community Medicine
Epidemiologist, Hyderabad
Yours husband seems to have contracted 'Syphilis' a deadly sexually transmitted disease. Take him to a good doctor (MD DVL or Gen. Medicine) and get him treated.
3 people found this helpful

Hi there I have syphilis I am taking treatment for that so please tell it is totally curable or it's not curable marriage proposals are coming Nowadays so shall have mutual bed sharing with my partner or not I feel scary does it spread to her also is there any problem if we give birth to a baby please reply is there any solution.

PGD In Ultraasonography, Non Invasive Cardiology Course, MD - Medicine, MBBS
General Physician, Narnaul
Yes. If it is treated early enough, syphilis can be cured completely by modern treatment before any permanent damage is done to the body. It is imperative that syphilis is diagnosed and treated in its very early stage. This also helps prevent its spreading. But most of the patients try to heal the ulcer and neglect the disease in the blood. People who have had syphilis cured can catch it again if they expose themselves to the risk of infection.
1 person found this helpful

My treponema pallidum test results is 7.52. What does it indicate about the titre of the infection. I am 10 weeks pregnant, however had already started the penicillin dosage of 1.2 million units weekly, two such dose already taken after my vdrl test was found to b reactive.

DNB (Obstetrics and Gynecology), PGDHHM, MBBS
Gynaecologist, Delhi
My treponema pallidum test results is 7.52. What does it indicate about the titre of the infection. I am 10 weeks pre...
if you already taking medicine then your treatment for syphilis is already started so,don't worry you will be cure early.your test show that you have positive test for syphilis.

Please explain about syphilis and treatment methods and medicine for that please.

DNB (Obstetrics and Gynecology), PGDHHM, MBBS
Gynaecologist, Delhi
Syphilis is a sexually transmitted infection caused by the bacterium treponema pallidum subspecies pallidum. Its better cure by precaution. Precautions like:- intimate physical contact with an infected person is effective at reducing the transmission of syphilis, as is the proper use of a latex condom. Mutually monogamous relationship with an uninfected partner and the avoidance of substances such as alcohol and other drugs that increase risky sexual behavior. Prevented by screening mothers during early pregnancy and treating those who are infected. Medication taken only guidance according to doctor.
1 person found this helpful

Popular Health Tips

Genital Tract Infection - Common Causes Behind It!

MBBS, DGO
Gynaecologist, Gurgaon
Genital Tract Infection - Common Causes Behind It!

While genital infections are an uneasy topic to discuss and seek treatment for, ignoring them leads to severe complications like infertility and even death. Most of these can be treated with a regular course of antibiotics and some topical treatment when identified early. Genital infections can be broadly classified into sexually transmitted and non-sexually transmitted. Read on to know some more common infections in both the categories.

Sexually transmitted diseases:

  1. Chlamydia: Caused by the bacteria Chlamydia trachomatis, it is the most common STD (sexually transmitted disease) and affects about 10% of 20 to 30 year olds. It is often asymptomatic, but in few cases, there could be increased vaginal discharge. Left undetected, it can lead to pelvic inflammatory disease (PID) and subsequently infertility.
  2. Gonorrhea: The bacteria Neisseria gonorrhea causes this STD, which is very common. There could be some irritation or discharge, but is mostly asymptomatic. Like Chlamydia, if not treated, it can lead to PID and infertility.
  3. HIV: The most dangerous of all, it causes AIDS, with immunosuppression as a major effect and affecting overall health. The women affected by HIV are more prone to candida and other genital infections.
  4. Genital warts: This viral infection is caused by human papilloma virus (HPV) and manifests as multiple warts on the vulva, vagina, and cervix and can cause cervical intraepithelial neoplasia (precancerous).
  5. Genital herpes: This virus again causes multiple small vesicles and ulcers around the vagina, painful urination, and swelling of the lymph nodes. Caused by type 1 herpes virus more commonly than type 2, it has a high chance of recurrence.
  6. Trichomonas: This STD manifests with very few symptoms and can go undetected for a long time. It can lead to PID and infertility.
  7. Syphilis: Caused by Treponema pallidum, there are 3 stages. The primary stage presents with an ulcer. The secondary presents with a rash, multiple genital warts, and oral warts/ulcers. It then goes into a latent phase and may subside without progression. In some cases, it reaches the tertiary stage and can affect various body organs including the liver, heart, or brain.

Non-sexually transmitted diseases: There two major genital infections not transmitted by sex are bacterial vaginosis and candidiasis.

  1. Bacterial vaginosis (BV): Constant change in the bacteria mix present in the genital area produces an imbalance and leads to altered pH and therefore BV. Pregnancy, intrauterine device, and frequent douching are proven risk factors for developing BV.
  2. Candidiasis: The genital tract usually has yeasts, and Candida vaginalis is present in the vagina. An overgrowth of this leads to infection. This can be caused by use of antibiotics (which destroy the good bacteria), diabetes, pregnancy, and birth control pills.

Early diagnosis and intervention of these infections can prevent severe symptoms in most cases. If you wish to discuss about any specific problem, you can consult a gynaecologist.

2648 people found this helpful

Common STDs in Women - Know the Facts

BUMS, MD
Sexologist, Jaipur
Common STDs in Women - Know the Facts

Although STDs are capable of affecting both genders, the impact on men and women is different. In women, this problem can cause long-term issues such as infertility in women. Although most STDs can be readily treated as soon as the symptoms surface, some cases might not throw up any symptom. Some of the curable STDs that can affect women are discussed below:

  1. Gonorrhoea: This STD is caused by bacteria living in mucous membranes of the vagina, urethra, mouth, rectum and eyes and is capable of spreading through contact. The symptoms in women include excessive discharge from the vagina, abdominal cramps, pain in the pelvic region and bleeding from the vagina after sex.

  2. Chlamydia: This STD is a result of a bacterial infection of ‘Chlamydia trachomatis’. Symptoms in females include burning sensation during urination, unusual vaginal discharge and bleeding between periods. Without treatment, the infection might spread to the urinary tract which could potentially cause PID (pelvic inflammatory disease) which is capable of causing problems in pregnancy and even infertility.

  3. Genital Herpes: Genital herpes is generally caused by the herpes simplex virus-2 (HSV-2) or the herpes simplex virus-1 (HSV-1). The virus is commonly known to be the chief cause of cold sores. Symptoms may appear soon after infection and usually are severe. This includes blisters, which turn into raw and painful sores that scab and heal over time. This might be accompanied by swollen lymph nodes and fever.

  4. Chancroid: This infection is caused by the bacterium ‘Haemophilus Ducreyi’. It occurs most commonly in the vulva (the female external genital organ that includes the clitoris, labia as well as the opening of the vagina). The condition starts out as a tender lump that appears during the incubation period after intercourse. The incubation period generally ranges between 3-10 days. The bump turns into an ulcer i.e. an open sore, due to the death of the cells. This is usually painful.

  5. Syphilis: It is caused by the bacterium ‘Treponema pallidum’ and the disease mainly occurs if you have sexual intercourse without any protection, that too with multiple sexual partners. The other mode of infection is blood transfusion. Symptoms of Syphilis include appearance of ulcers around the genitals or the oral region known as a chancre, severe rashes around the hand or feet coupled with other symptoms of mild fever, headache, throat pain and immense fatigue. If you wish to discuss about any specific problem, you can consult a gynaecologist.

3507 people found this helpful

Common STDs in Women: Get the Facts!

MBBS, MCCEE, Fellowship in Sexual Medicine
Sexologist, Jaipur
Common STDs in Women: Get the Facts!

Although sexually transmitted diseases (STDs) are capable of affecting both genders, the impact on men and women is different. In women, this problem can cause long-term issues such as infertility. Although most STDs can be readily treated as soon as the symptoms surface, some cases might not throw up any symptom. Some of the curable STDs that can affect women are discussed below:

 

  1. Gonorrhoea: This STD is caused by bacteria living in mucous membranes of the vagina, urethra, mouth, rectum and eyes and is capable of spreading through contact. The symptoms in women include excessive discharge from the vagina, abdominal cramps, pain in the pelvic region and bleeding from the vagina after sex.

  2. Chlamydia: The STD is a result of a bacterial infection of ‘Chlamydia trachomatis’. Symptoms in females include burning sensation during urination, unusual vaginal discharge and bleeding between periods. Without treatment, the infection might spread to the urinary tract which could potentially cause PID (Pelvic Inflammatory Disease) which is capable of causing problems in pregnancy and even infertility.

  3. Genital Herpes: Genital herpes is generally caused by the herpes simplex virus-2 (HSV-2) or the herpes simplex virus-1 (HSV-1). The virus is commonly known to be the chief cause of cold sores. Symptoms may appear soon after infection and usually are severe. This includes blisters which turn into raw and painful sores that scab and heal over time. This might be accompanied by swollen lymph nodes and fever. You can also take the package for Living Healthy - Woman.

  4. Chancroid: This infection is a STD caused by the bacterium ‘Haemophilus Ducreyi’. It occurs most commonly in the vulva (the female external genital organ that includes the clitoris, labia as well as the opening of the vagina). The condition starts out as a tender bump that appears during the incubation period after intercourse. The incubation period generally ranges between 3-10 days. The bump turns into an ulcer i.e. an open sore, due to the death of the cells. This is usually painful.

  5. Syphilis: It is caused by the bacterium ‘Treponema pallidum’ and the disease mainly occurs if you have sexual intercourse without any protection, that too with multiple sexual partners. The other mode of infection is blood transfusion. Symptoms of Syphilis include appearance of ulcers around the genitals or the oral region known as a chancre, severe rashes around the hand or feet coupled with other symptoms of mild fever, headache, throat pain and immense fatigue.

If you wish to discuss about any specific problem, you can consult a specilized gynaecologist and ask a free question.

5625 people found this helpful

Most Common STDs in Women

DNB (Obstetrics and Gynecology), Fellowship in Minimal Access Surgery, MS - Obstetrics and Gynaecology, MBBS
Gynaecologist, Gurgaon
Most Common STDs in Women

Most of us are affected by diseases, which spread through physical contact, but most of us do not consider it important to get them checked, due to which they turn into major ailments. Sexually Transmitted Diseases (STDs) are infections, which are transmitted through any kind of sexual contact. The organism that causes the disease is transmitted from one person to the other during sex intercourse. Sometimes STDs can be asymptomatic (no symptoms or signs)

Here are some STDs that you should be informed about:

1. Gonorrhoea: Genital infection caused by bacteria is called gonorrhoea, its symptoms include 

2. Chlamydia: Bacterial infection in the genital tract is called chlamydia. Chlamydia is usually difficult to diagnose, its symptoms include

  • Pain during urination
  • Pain in lower abdomen
  • Vaginal discharge
  • Painful intercourse
  • Bleeding between menstrual cycles

3. Syphilis: The bacterium Treponema pallidum causes syphilis,  its symptoms include

  • Rashes
  • Sores in the mouth, anus or vagina
  • In later stages, it causes nerve and organ damage

4. Genital Herpes: The herpes simplex virus (HSV) causes herpes. Signs and symptoms include-

  • Small red bumps or ulcers in the anal, genital and other areas
  • Itching or pain around the genital area, thighs and buttocks

5. Human Papillomavirus (HPV) and Genital Warts: Genital warts are caused by HPV. It infects the genital tract. HPV has been linked to cervical cancer,  its symptoms include

  • Small swellings in the genital area
  • Itching
  • Bleeding during sex

6. Chancroid: Chancroid is a bacterial infection. The bacterium Haemophilus ducreyi causes chancroid, its symptoms include

  • Development of red bumps on the skin folds covering the genitals
  • Pain during urination
  • Burning sensation during bowel movement

7. Ectoparasitic Infections: Ectoparasitic infections are caused by small parasitic bugs like mites or lice. The parasites usually affect the hair or skin. Scabies and crabs are common parasites that cause such infections. They both cause intense itching and visible rashes.

8. Human Immunodeficiency Virus (HIV) and Acquired Immunodeficiency Syndrome (AIDS): The virus that causes AIDS is called HIV. It can spread through blood, vaginal fluids, semen and breast milk. Unprotected sex or sharing needles with an infected person is how the disease spreads. It includes symptoms, such as

4605 people found this helpful

Syphilis: Can This Sexually Transmitted Disease be Cured?

MBBS, PGDUS, Fellowship In Aesthetic Medicine, Advance Course In Diabetes - USA, MD - Medicine
Aesthetic Medicine Specialist, Delhi
Syphilis: Can This Sexually Transmitted Disease be Cured?

Syphilis is a contagious disease that is sexually transmitted through oral or anal sex. The disease can even be passed from one person to another through kissing for a long time or through physical contact. A pregnant woman is at a high risk of passing the disease to her newborn which can cause abnormalities and even death of the baby. It is caused by the bacteria treponema pallidum.

Symptoms of syphilis

  1. Primary stage: the symptoms of syphilis are visible within three weeks which appears as a single and painless sore on the penis or inside vagina and rectum.
  2. Secondary stage: in the secondary stage, the symptoms manifest themselves as red or brown spots visible on soles of feet or palms of hand. They can be accompanied by fever, headache, swollen glands, fatigue and hair loss in patches.
  3. Latent stage: in this stage, a person has no symptoms but the infection is still present in the body.
  4. Late stage: this stage occurs 10-20 years after a person had first contracted syphilis. In this stage, the organs are severely damaged, including heart, brain and nervous system. It can cause paralysis or even death.

Can this condition be cured?

With a single dose of the antibiotic penicillin, syphilis is easily curable in its early stage. If the condition persists for over a year, additional doses might be required. It should be treated early to prevent further complications. There are other options for patients who are allergic to penicillin. Until the sore or rash heals completely, after the treatment of syphilis, you should abstain from having sex. If syphilis is left untreated, some severe and permanent damage can be triggered by it, including blindness, dementia or even death.

4219 people found this helpful