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Health Benefits of Grapeseed Oil, Uses And Its Side Effects

Last Updated: Sep 03, 2020

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Grape seed oil is very popular and used for various purposes such as cooking, cosmetics and maintaining good health. The main ingredients of this oil are grapes. This oil is loaded with flavonoids, vitamin E, linoleic acid, oligomeric proanthocyanidin and polyphenols. It helps deal with cancer, cardiovascular health, lower obesity and kidney problems.

Grapeseed Oil is also used to treat edema, arthritis, wrinkles, acne, age spots, dry or itchy skin, chapped lips, bruising, wounds, varicose veins, stretch marks, hemorrhoids, premature aging, weight loss, premenstrual syndrome, dandruff, stress, cardiovascular ailments, warts, hair loss, hypertension, atherosclerosis, diabetes, high cholesterol levels, cataracts, visual impairment, macular degeneration and many more.

About Grapeseed Oil

Grape seed oil is pale yellow colored fatty oil, which is derived from grape seeds by extraction and pressing. It is an industrial product that possesses strong antioxidant compounds called procyanidolic oligomers. It is low in nutrients, but high in omega-6 fatty acids. The health claims for this oil are based on the supposedly high amounts of nutrients, antioxidants and polyunsaturated fats.

Nutritional Value of Grapeseed Oil

Grape seed oil contains 40 calories per teaspoon. This calorie content is similar to other plant-based oils, such as olive, canola and peanut oils. The publication 'Dietary Guidelines for Americans, 2010' suggests consuming 6 teaspoons of oils daily when following a 2000-calorie meal plan and 7 teaspoons of oils daily when following a 2500-calorie diet. Being fat, it doesn’t contain any protein or carbohydrates -including sugar.

A teaspoon of grape seed oil provides 4.5 grams of total fat. The majority of fats in grape seed oil or 3.9 grams are poly and mono-unsaturated fats. Only 0.4 gram of fat in 1 teaspoon of grape seed oil is from saturated fatty acids. The predominant polyunsaturated fatty acids found in grape seed oil are omega-6 fatty acids. This is according to a 2009 study published in the “International Journal of Food Sciences and Nutrition.” Whereas, according to the University of Maryland Medical Center omega-6 fatty acids is essential in our diet as our body cannot produce them.

Grape seed Oil also plays an important role in brain function, normal growth and development, skin and hair growth, bone health, metabolism and reproduction. The same source notes that some omega-6 fatty acids promote inflammation. But a 2013 study in the “International Journal of Food Sciences and Nutrition” found that grape seed oil seems to improve inflammation and insulin resistance in overweight and obese women.

Grapeseed Oil is an excellent source of vitamin E, an antioxidant that helps prevent cell damage in our body and strengthens our immune system. One teaspoon of grape seed oil contains 1.3 milligrams of vitamin E. The recommended dietary allowance or RDA for vitamin E is 15 milligrams daily for adult men and women. This is according to the Institute of Medicine.

Nutritional facts Per 100 grams

100 g
Total Fat

Health Benefits of Grapeseed Oil

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Mentioned below are the best health benefits of Grapeseed Oil

Rosemary oil for skin cancer

Cancer is a disease in which cells present themselves with an unrestricted proliferative potential. On a microscopic level, phytochemicals inhibit cancerous changes along all stages of tumor growth i.e. from initiation to growth on to metastasis.

Phytochemicals are most effective in preventing cancerous changes when consumed in healthy quantities over long periods of time. Thus, suddenly increasing consumption of grapes seeds following a cancer diagnosis is unlikely to cure the cancer, but it may increase a person’s immunity to fight the cancer naturally.

Grape seeds contain a group of phytochemical antioxidants known as proanthocyanidins. Researchers believe the anti-cancer benefits of GSE come from these proanthocyanidins, which contain more antioxidant power than vitamin C and E combined. Therefore, it can be used to prevent cancer.

Grape seed oil is a good source of gamma-tocotrienol form of vitamin E, which has shown to inhibit important steps in metastasis in both hormone receptor positive and triple negative breast cancer cells. Gamma-tocotrienol has also been found to enhance the toxic effects of adriamycin in breast cancer cells.

Rosemary essential oil for blood circulation and pressure

Blood pressure refers to the resistance produced each time the heart beats and sends blood coursing through the arteries. It normalizes high blood pressure. Antioxidants, including flavonoids, linoleic acid and phenolic procyanidins in grape seed oil help protect our blood vessels from damage, which may help to prevent high blood pressure.

Grapeseed oil for cognitive function

Grape seed oil boosts cognitive abilities and overall brain health. It helps to prevent free-radical brain damage and also improves one’s memory. It helps reduce stress and inflammation in the brain. It is also being studied for its potential life extension and anti-aging effects.

Grape seed oil reduces aggregation of brain amyloid cells thus improving cognition. It is able to lower unwanted compounds, such as hydrogenperoxide, cellular damage and blood glucose and also increases good compounds like sulfhydryl content.

Rosemary oil for osteoarthritis pain and inflammation

1 (OA) is a common inflammatory joint disease affecting a growing part of elderly people and is associated with a strong socio-economic impact. Grape seed oil contains plyphenols that exert a large range of beneficial effects in the prevention of age-related diseases.

In rheumatoid arthritis, it decreases many bad changes. It is able to significantly reduce many of the inflammatory markers and induces production of Th2 cytokines and Tregs. In autoimmune arthritis it reduces several inflammatory cytokines. It decreases the amount of markers for bone erosion and increases the amount of mature bone forming components.

Grape seed oil is able to reduce several pain indexes in osteoarthritis and decreases many of the inflammatory markers.

Rosemary oil for skin benefits

Grape seed oil has great amount of vitamin E which provides antioxidants for our skin. It treats acne, tightens skin, helps diminish dark circles around the eyes, moisturizes, reduces scars, restores collagen and fights aging.

Rosemary essential oil for diabetes patients

Grape seed oil deals with diabetes by the improvement in fat profile, weight loss, bradycardia, and low blood pressure. Because of its antioxidant abilities, it is able to improve oxidative damage and general antioxidant levels in diabetic patients. It prevents heart damage and disorders caused by diabetes. It enhances insulin, increasing its ability to stimulate organs.

Rosemary essential oil for cholesterol levels

Proanthocyanidin that is found in grape seed oil can have a positive effect on cardiovascular disease prevention. It hardens the arteries and decreases blood cholesterol. It reduces free radical formation, heart fibrillation, tachycardia and improves aortic flow including heart flow after surgeries.

Bone density

Grape seed oil is essential to build bone density. It improves bone formation and bone strength. Proanthocyanidins extract is good for bones.

Grape seed Oil for oral health

A study conducted on cells found that grape seed oil extract is effective in rematerializing teeth, a process that is used to prevent or reverse early tooth decay. In tests, tooth samples were washed with a solution containing grape seed extract for eight days and the data showed that it had been more rematerialized than the other control groups.

Rosemary good for stomach ulcers and cramps

Grape seed oil is able to increase intestinal integrity. It increases bacteroides count and restores the lactobacilli count. It increases intestinal tight junction proteins and decreases fecal levels which are a marker of intestinal inflammation.

Metabolic syndrome

Grape seed oil decreases the blood fat levels and also decreases the amount of fat accumulation especially in white fat tissues. It corrects elevated triglycerides, most likely through the mechanism of suppressing liver fat production. It also inhibits lipase activity in test tubes and thus may be useful for reducing free fatty acids and accumulation of fat in fat tissues.

Anti-bacterial properties of grape seed oil

In-vitro grape seed oil is able to inhibit the activity of many bacteria (Bacillus cereus, Bacillus coagulans, Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa). It is more effective against gram-positive than gram-negative bacteria.

Uses of Grapeseed Oil

In the 20th century, this oil was widely used as cooking oil. After the advancement of technology and due to its neutral taste and high smoking point, it made an excellent choice for frying and sautéing. It's rich in cholesterol-lowering polyunsaturated fats.

Grape seed oil is used hugely for its health benefits. It is also used in soap and paint. Other than that, it deals with diseases and physical problems. It truly is a useful thing to keep us healthy and keep our skin beautiful.


Side-Effects & Allergies of Grapeseed Oil

Grape seed oil has some side effects lke diarrhea, upset stomach, vomiting and dry mouth. It can also cause sore throat, cough, headache, muscle pain, dizziness and itchy scalp.

Grape seed oil is considered safe at recommended dosages and is not safe for pregnant women and children. It is important to talk to a doctor before taking it as it can affect the way certain medications are broken down in the liver.

Origin And Cultivation of Grapeseed Oil

Grape seed oil has some side effects lke diarrhea, upset stomach, vomiting and dry mouth. It can also cause sore throat, cough, headache, muscle pain, dizziness and itchy scalp. Grape seed is considered safe at recommended dosages and is not safe for pregnant women and children. It is important to talk to a doctor before taking it as it can affect the way certain medications are broken down in the liver.


  • Nassiri‐Asl M, Hosseinzadeh H. Review of the pharmacological effects of Vitis vinifera (Grape) and its bioactive constituents: an update. Phytotherapy Research. 2016 Sep;30(9):1392-403. [Cited 26 June 2019]. Available from:
  • Nassiri‐Asl M, Hosseinzadeh H. Review of the pharmacological effects of Vitis vinifera (Grape) and its bioactive compounds. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives. 2009 Sep;23(9):1197-204. [Cited 26 June 2019]. Available from:
  • Ma Z, Zhang H. Phytochemical constituents, health benefits, and industrial applications of grape seeds: A mini-review. Antioxidants. 2017 Sep;6(3):71. [Cited 26 June 2019]. Available from:

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    Written ByDrx Hina FirdousPhD (Pharmacology) Pursuing, M.Pharma (Pharmacology), B.Pharma - Certificate in Nutrition and Child CarePharmacology
    Reviewed By
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    Reviewed ByDt. Ms. Shilpa MarwahB.Sc (Home Science), Post Graduation Diploma in Dietetics and Public Health NutritionDietitian/Nutritionist

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