I have had migraine for about 15 years but lately it became worse and became chronic so I sought treatment and went to a neurologist. The Dr. Prescribed my 25 mg topiramate (25 mg increment per week to 100 mg daily) + 20 mg propranolol. This has greatly helped me get rid of migraine. Its been three months since I started taking it but now I feel like this medicine is making me angry all the time. I get depressed as well. My mood swings are off the charts. I feel like crying one minute and the next im ok? Is it possible?