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Artilup Capsule

Manufacturer: Lupin Ltd
Medicine composition: Indomethacin
Prescription vs.OTC: Prescription by Doctor required

Artilup Capsule is a non-steroidal anti-inflammatory drug which works by reducing hormones responsible for pain, fever, stiffness, swelling and inflammation in the body. It is used to treat moderate to severe gouty arthritis, osteoarthritis, rheumatoid arthritis or ankylosing spondylitis. It also treats shoulder pain caused by tendinitis or bursitis.

If you have a heart disease, high blood pressure, high cholesterol, diabetes, or if you smoke, do not use this medicine. Before using this medicine inform your doctor if you have a history of heart attack, stroke, blood clot, stomach ulcers, liver or kidney disease, asthma or fluid retention. Tell your doctor if you are pregnant or plan to become pregnant while using Artilup Capsule. You should not breast-feed while using this medicine. It is also not recommended for use by anyone younger than 14 years old.

This medicine can cause a few side effects including changes in your vision, shortness of breath, swelling or rapid weight gain, skin rash, bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds, liver problems, kidney problems, anemia or severe skin reaction.

This medicine comes in regular capsules, liquid form, extended-release capsules and suppositories. A typical dose for osteoarthritis, rheumatoid arthritis or ankylosing spondylitis is 75 mg, taken two or three times a day.

Information given here is based on the salt and content of the medicine. Effect and uses of medicine may vary from person to person. It is advicable to consult a Orthopedist before using this medicine.

, arthralgia, myalgia, dental pain, post operative pain, pain during menstruation,
In addition to its intended effect, Artilup Capsule may cause some unwanted effects too. In such cases, you must seek medical attention immediately. This is not an exhaustive list of side effects. Please inform your doctor if you experience any adverse reaction to the medication.
Is It safe with alcohol?
Taking indomethacin with alcohol can increase the risk of stomach bleeding.
Are there any pregnancy warnings?
Imacin 75mg capsule sr is unsafe to use during pregnancy.
There is positive evidence of human fetal risk, but the benefits from use in pregnant women may be acceptable despite the risk, for example in life-threatening situations. Please consult your doctor.
Are there any breast-feeding warnings?
Unknown. Human and animal studies are not available. Please consult your doctor.
Is it safe to drive while on this medicine?
Caution is advised when driving or operating machinery.
Does this affect kidney function?
Caution should be used in patients with impaired renal function.
Does this affect liver function?
There is no data available. Please consult doctor before consuming the drug.
Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.
Interaction with Medicine
Zydol 50Mg Suspension
Artilup Capsule is an analgesic anti-inflammatory agent. It competitively inhibits Cyclooxygenase 1 and 2, inhibiting formation of prostaglandins involved in fever, pain, and inflammation. It also inhibits arachidonic acid formation from phospholipids.
Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

Popular Questions & Answers

Suggest any solution for ankylogy spondylitis. Tell me natural resources of indomethacin which can useful in freeze muscle.

Physiotherapist, Mumbai
Hi Regular exercise will slow down the process. do spine flexibility exercise which includes spine extension or bhujangasan, you can consult physiotherapist for same. use straight back chair.

I am 24 years old male. I am having daily dosage of indomethacin 50 mg. What are the side effects of it and when will it start?

Homeopath, Hooghly
I am 24 years old male. I am having daily dosage of indomethacin 50 mg. What are the side effects of it and when will...
Well indomethacin have soo many side effects. Some serious side effect-heart attack, stroke,dizziness, some skin lession, shortness of breath. Some less serious side effects-nausea, vomiting,stomach pain, gastric upset, diarrhoea,headache, nervousness,rash, weight gain. Soo I think you should stop it. U must do homoeopathic treatment for your arthritis problem. Whatever your suffering from. Like rheumatoid arthritis, gouty arthritis, rheumatic arthritis, by proper homeopathic treatment it is curable. Indomethacin will only supress your pain will not cure your problem. Soo go for homoeopathic treatment. Soo you can contact me through Lybrate.
3 people found this helpful

Is it bad to have tab Microcid SR (Indomethacin) for a long time? Treatment for gout.

MBBS, CCEBDM, Diploma in Diabetology, Diploma in Clinical Nutrition & Dietetics, Cetificate Course In Thyroid Disorders Management (CCMTD)
Endocrinologist, Dharwad
Is it bad to have tab Microcid SR (Indomethacin) for a long time? Treatment for gout.
Hello, Thanks for the query. Indomethacin is a nonsteroidal anti-inflammatory drug with very good action, but should be used with caution. Long term use is not very safe, as it may cause gastrointestinal bleeding, ulceration, may damage kidneys. It is better to use it for a short period of say few days. Thanks.
1 person found this helpful

I am 24/M. I have been having indomethacin 50 mg daily from last 8 yrs. Whenever I miss a dose, it pains a lot. HLAB27 report is also positive. How can I stop taking this pain killers?

BAMS, MD, Panchakrma
Ayurveda, Nashik
I am 24/M. I have been having indomethacin 50 mg daily from last 8 yrs. Whenever I miss a dose, it pains a lot. HLAB2...
Hello lybrate-user, ayurved has very good results in such cases like you. If you start proper ayurvedic treatment & panchakarma. We can stop your pain as well fusion & other issues of spine in future. Daily stretching exercise is must for you. After analyzing detail reports I 'll guide you.

Popular Health Tips

Risk Factors for High Blood Pressure (Hypertension

General Physician, Himatnagar
Risk Factors for High Blood Pressure (Hypertension
Risk factors for high blood pressure (hypertension)
The top 10 risk factors for high blood pressure include:
Being overweight or obese

The more you weigh the more blood flow you need to supply oxygen and nutrients to your tissues. As the volume of blood circulated through your blood vessels increases, so does the pressure inside your arteries.

Too much salt (sodium) in your diet

Too much sodium in your diet can cause your body to retain fluid, and also causes the arteries in your body to constrict. Both factors increase blood pressure.

Too little potassium in your diet

Potassium helps balance the amount of sodium in your cells. Potassium causes the smooth muscle cells in your arteries to relax, which lowers blood pressure.

Not being physically active

Exercise increases blood flow through all arteries of the body, which leads to release of natural hormones and cytokines that relax blood vessels, which in turn lowers blood pressure. Lack of physical activity also increases the risk of being overweight.

Drinking too much alcohol

Having more than two drinks per day can cause hypertension, probably by activating your adrenergic nervous system, causing constriction of blood vessels and simultaneous increase in blood flow and heart rate.


High levels of stress can lead to a temporary, but dramatic, increase in blood pressure. If you try to relax by eating more, using tobacco or drinking alcohol, you may only exacerbate problems with high blood pressure. Relaxation and meditation techniques effectively lower blood pressure.

Non-steroidal anti-inflammatory drugs (nsaids)

Ibuprofen (advil, motrin, ibuprofen) can cause marked worsening of existing hypertension or development of new high blood pressure. It can also cause damage to the kidneys, worsening of heart failure, and even heart attack or stroke. Ibuprofen is a member of the class of drugs called nsaids, which includes naproxen (aleve, naprosyn, and anaprox), sulindac (clinoril), diclofenac (voltaren), piroxicam (feldene), indomethacin (indocin), mobic, lodine and celecoxib (celebrex).

Cough and cold medications (sudafed and other brands that contain pseudoephedrine and phenylephrine)

Cough and cold medicines frequently contain decongestants such as pseudoephedrine and phenylephrine. These medications cause your blood pressure and heart rate to rise, by constricting all your arteries, not just those in you nose.

Certain chronic conditions

Certain chronic conditions also may increase your risk of high blood pressure, including diabetes, kidney disease and sleep apnea.

A diet low in vitamin d

It's uncertain if having too little vitamin d in your diet can lead to high blood pressure. Researchers think that vitamin d may affect an enzyme produced by your kidneys that affects your blood pressure. More studies are necessary to determine vitamin d's exact role in high blood pressure. However, talk to your doctor about whether you may benefit from taking a vitamin d supplement.
116 people found this helpful

Ulnar Tunnel Syndrome

MS - Orthopaedics, MBBS
Orthopedist, Mumbai
Ulnar Tunnel Syndrome

The Ulnar nerve is the longest unprotected nerve in the human body (meaning it is not protected by any bones or muscles), and is also one of the predominant nerves that enables efficient sensation and function to the hand. The Ulnar nerve begins at the neck and travels all the way down the inside of the forearm to the palm of the hand. However, at this point, the Ulnar nerve branches out within the palm and into the ring and little fingers.

Ulnar Tunnel Syndrome of the wrist is a condition characterized by an entrapment of the Ulnar nerve as it passes through the Guyon's canal within the wrist. Women are more likely to develop this condition than men because of incessant household works and also sitting at the table and working on the laptops and desktops on an everyday basis.

The most common cause of Ulnar Tunnel Syndrome is a ganglion cyst, which is a non-cancerous fluid-filled lump that usually originates from the wrist joint.

The treatment of Ulnar Tunnel Syndrome of the wrist includes both non-surgical and surgical methods. Usually, people who are diagnosed with this syndrome at the first stage can be cured with simple physiotherapy at home.

Ulnar Tunnel Syndrome of the wrist may occur in individuals of all ages, races, ethnic groups and gender but majorly as per the reports, women are more likely to develop this condition than men. From the past studies, it is seen that the individuals who participate in sports that involve repetitive stress on the wrist, such as gymnastics , table tennis, lawn tennis , badminton are the common and frequent victims of the syndrome.

Also, certain occupations that require repetitive overuse of the wrist, such as carpentry or painting are also sufferers of this syndrome.

The common signs and symptoms of Ulnar Tunnel Syndrome are as follows;-

  • Tingling sensation within the little finger(pinky) and ring finger.
  • The patient might feel pain within the wrist.
  • The person might also face difficulty while gripping objects.
  • Loss of Ulnar nerve function.

Techniques which help in the diagnosis of Ulnar Tunnel Syndrome are as follows :-

  • Physical Examination:- A thorough physical examination is important in determining if an individual has Ulnar Tunnel Syndrome of the wrist. During the process, a physician will examine the hand to look for any common signs of the syndrome such as a diminishing or loss of muscle tissue, muscle weakness or dry skin within the spaces between the fingers.
  • X-rays:- This process uses radiation to produce images of the wrist.
  • Computerized Tomography of the wrist joint:- A CT SCAN takes a series of X-ray images from several different angles. These images are then intermingled to create cross-sectional images of bones and soft tissues with the body.
  • Magnetic resonance imaging:-  An MRI is a more scrutinized scan that uses strong magnetic fields to produce clearer and transparent images of the bones and soft tissue that surrounds the wrist.
  • Electromyography(EMG):- An EMG shows the electrical activity of the muscle during rest and contraction of the muscle.
  • Nerve conduction velocity (NCV):- Nerve conduction velocity shows the  speed at which electrical signals move through a nerve.

Treatment for Ulnar tunnel syndrome:

The treatment measures for Ulnar Tunnel Syndrome of the wrist include both non-surgical and surgical methods:-

Surgical Method:

  • Surgical excision - Surgical excision involves the removal of the ganglion cyst, scar tissue, or it may help mitigate any other factor that causes compression of the ulnar nerve.
  • Endoscopic Ulnar- Endoscopic ulnar tunnel release is a minimally invasive surgical procedure that allows a physician to examine the carpal tunnel within the wrist using an orthopedic device called an endoscope.

Non-surgical method:

  • Applying ice or a damp heated towel to the wrist can help reduce pain and swelling.
  • Any activity that aggravates the wrist condition should be avoided.
  • Complete immobilization of the wrist with a cast may be required to restrict movement.
  • Non-steroidal anti-inflammatory oral medications, such as indomethacin and naproxen, may be used to treat Ulnar Tunnel Syndrome.
  • Corticosteroid injections help in temporary relieving symptoms, such as pain, and in improving the range of motion.
  • It is important to begin some light exercises after the symptoms  have decreased. Physical therapy may help restore strength, as well as flexibility in the muscles.
3 people found this helpful


General Physician, Secunderabad

Spondyloarthritis (also known as spondyloarthropathy) is the term which describes the connective tissue diseases. It is the group of inflammatory diseases, including arthritis of the peripheral joints and spine (sacroiliitis or spondylitis); including the area where ligaments and tendons attach to bones (enthesitis or enthesopathy). These diseases cause pain or stiffness in the leg or arm joints, spine, ligaments and tendons become inflamed. Skin rashes, eye, and intestinal problems may also be able to occur.


  • Spondyloarthritis is a pathology that specifically strikes young people. The symptoms most frequently start before the age of 45. It affects more males than females.
  • Predisposition to spondyloarthritis, especially spa, is determined largely by genetic factors.
  • The incidence rate is higher in populations with a higher prevalence of hla-b27.
  • Psoriatic skin lesions and colitis due to inflammatory bowel disease (ibd) have been considered as both basic, subtype-defining entities with their own genetic background (distinct from hla-b27 genotype), and as manifestations of spondyloarthritis.
  • There is a strong need to diagnose patients with spa in an earlier stage; currently, there is a delay of 5–10 years between onset of the first symptoms and diagnosis.


There are five types of spondyloarthritis

Ankylosing spondylitis or bechterew disease: it is the type of arthritis that affects the spine. Symptoms include pain and stiffness in the lower back and in the neck. Spine bones fuse together and it will become rigid spine and it leads to stoope over posture.

Psoriatic arthritis: psoriatic arthritis is the form of arthritis that affects the people who have psoriasis. Most people diagnosed with psoriasis and later diagnosed with psoriatic arthritis. It may affect any part of the body such as fingertips and spine. The main symptoms are joint pain, stiffness, and swelling.

Psoriatic arthritis

Reactive arthritis: it occurs due to the infection by certain bacteria. Often the bacteria’s from genitals (chlamydia trachomatis) or bowel (campylobacter, salmonella, shigella, and yersinia). It usually targets your knees and joints of ankles or feet.

Reactive arthritis

Undifferentiated arthritis: undifferentiated inflammatory arthritis does not conform to any of the recognized inflammatory arthritis types. It may include monoarthritis of a single joint; oligoarthritis, which is usually when four or fewer joints are involved; or polyarthritis, which usually involves many small joints.

Risk factors

Risk factors may be higher due to following reasons:

  • Family member having the gene which causes spondyloarthritis
  • Positive results for the hla-b27 gene
  • Recurring bacterial infection in your gut
  • Have other inflammatory conditions such as psoriasis or inflammatory bowel disease


  • The main cause is not known, but researchers pointed out that the hereditary genetics playing an important role in this disease. Since this disease occurs often in family members of patients who have spondyloarthritis.
  • Many genes cause it. Up to 30 genes have been found. But the major gene that causes spondyloarthritis is hla-b27.
  • Bacterial infections can also cause reactive spondyloarthritis known to be triggered by a bacteria chlamydia or food borne infections.

Symptoms and complications of spondyloarthritis

The first and major symptoms of all types of spondyloarthritis are severe low back pain, swelling of arms, stiffness, and fatigue. The different types of spondyloarthritis can be manifested by the following signs and symptoms.

  • Alternative or unilateral buttock pain
  • Arthritis in small joints
  • Arthritis in large joints such as knee joint, ankle joint and elbow joint (peripheral arthritis)
  • Numbness and tingling sensation in arms and legs
  • Spinal fusion may occur in ankylosing spondylitis
  • Inflammation at the interfaces between bone and tendon or ligament of limbs (enthesitis)
  • Inflammation of intestine, urinary tract and aortic heart valves. These can lead to spinal joints inflammation.
  • Inflammation of joints in pelvis and spine (sacroiliitis)
  • Enteropathic arthritis shows symptoms such as diarrhea and abdominal pain
  • Digestive problems
  • Skin disease like psoriasis
  • Osteoporosis
  • Redness of eye (iritis)
  • Swollen fingers and
  • Pain in the heels cause difficult to walk, stand even for small duration

Diagnosis and testing

First a doctor may ask for patient’s medical history, physical exam and may suspects for symptoms of spondyloarthritis. To confirm doctor may perform the following diagnosis and tests.

  • X-rays: x-ray images shows the change of the sacroiliac joints in the pelvis and fusion of spine. If these changes not observed, but symptoms shows spondyloarthritis doctor will suggest mri scan. Mri shows these changes more promptly than the x-ray.
  • Mri scans: it can show a very clear image of enthesitis and also the changes of sacroiliac joints.
  • Ct scans: ct also used for the imaging of bone joints.
  • Hla-b27: most patients with spondyloarthritis have hla-b27 gene, but some people don’t have this gene. So it is necessary to go for a hla-b27 test if the symptoms suspects spondyloarthritis.
  • Complete blood count (cbc): cbc can be useful to find the inflammation.
  • Musculoskeletal ultrasound scanning: ultrasound imaging uses sound waves to produce the images of inflammatory conditions of muscles, ligaments, and tendons.
  • Dual-energy x-ray absorptiometry (dexa) scans: used for measuring the bone mineral density usually the bones of the lower spine and hips. Bone loss is measured through this technique.

Treatment of spondyloarthritis.

  • There is no way to cure this disease condition, but there are treatments to counterparts the symptoms.
  • Nonsteroidal anti-inflammatory drugs: certain nsaid’s like naproxen, ibuprofen, meloxicam, or indomethacin are prescribed by doctors to relief from the pain due to symptoms.
  • Corticosteroid medication: inflammation around the tendons and in the joints can be overcome by taking some corticosteroid drugs. This helps to reduce the swelling in the joints.
  • Antibiotics: antibiotics can be used in the case of reactive spondyloarthritis in which bacteria cause the major problems.
  • Disease-modifying antirheumatic drugs (dmard’s): sulfasalazine (azulfidine) and methotrexate are the best dmard’s to be used for the joint damages in limbs affected by arthritis.
  • Tumor necrosis alpha (tnf-alpha) blockers: fda approved tnab are adalimumab (humira), adalimumab-atto (amjevita), a biosimilar to humira, certolizumab pegol (cimzia), etanercept (enbrel), etanercept-szzs (ereizi), a biosimilar to enbrel, golimumab (simponi), infliximab (remicade), infliximab-dyyb (inflectra), a biosimilar to remicade, and secukinimab (cosentyx). These are biosimilars used to treat arthritis in spine joints.
  • Surgery: patients with over inflammation of pelvis joints needs hip replacement. In the case of heavy damage in the cartilage of joints needs surgery to repair. In some rare cases, spinal surgery also needed.

Prevention and control measures

  • Prevention from spondyloarthritis needed some lifestyle changes as follows.
  • Quit smoking: smoking speeds up the spinal fusion in addition to other bad health effects.
  • Follow good posture: practicing a proper sitting and posture makes your spine to escape from growing into slumped-over position and strain.
  • Daily physical exercise: frequent home exercise and physiotherapy is essential to reduce the stiffening of spine and other joint problems. It also helps to have your heart healthy.
  • Good diet: follow the diets that are rich in calcium. Dairy products are preferred foe calcium rich foods.
Psoriatic arthritis
3 people found this helpful

Table of Content

About Artilup Capsule
When is Artilup Capsule prescribed?
What are the side effects of Artilup Capsule ?
Key highlights of Artilup Capsule
What are the interactions for Artilup Capsule ?