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Doctors diagnose vitamin deficiency anemias through blood tests that check: The number and appearance of red blood cells. People with anemia have fewer red blood cells than normal. In vitamin deficiency anemias related to a lack of vitamin B-12 and folate, the red blood cells appear large and underdeveloped. Vitamin B12 deficiency symptoms may include: strange sensations, numbness, or tingling in the hands, legs, or feet. Difficulty walking (staggering, balance problems) anemia. A swollen, inflamed tongue. Yellowed skin (jaundice) difficulty thinking and reasoning (cognitive difficulties), or memory loss.
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