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Prescription vs.OTC: Prescription by Doctor required
Last Updated: October 23, 2020

Levofloxacin is a medicine that is a member of the fluoroquinolone antibiotic family. It fights against bacterial infections like tuberculosis, pneumonia, laryngitis, cellulitis, gastroenteritis, acute or chronic bronchitis, urinary tract infections, tonsillitis, anthrax and plague. This antibiotic also treats infections of the pelvis, kidney, prostate and skin.

Levofloxacin may also be used for uncomplicated skin and skin structure infection (due to S. aureus or S. pyogenes) and complicated urinary tract infection due to gram-negative Enterobacter sp, including acute pyelonephritis (caused by E. coli).

Levofloxacin works by killing the bacteria that are causing an infection. It hinders the process of cell replication and cell division, within the cell of the bacteria, by inhibiting the synthesis of the DNA gyrase enzyme. Without this enzyme, the cell of the bacteria cannot survive or grow. Hence, Levofloxacin behave as bactericide.

Levofloxacin fights against bacteria that are Gram-positive as well Gram-negative. This broad-spectrum antibiotic is effective in inhibiting the synthesis of enzymes called DNA gyrase, which is essential to the process of replication and division of bacterial cells. Thus, Levofloxacin inhibits the cell division of the bacteria, making it impossible for them to survive. This makes it effective in treating bacterial infections.

The doctor will prescribe instructions for taking Levofloxacin according to your condition, the severity of that condition and the other medications you are taking. It is important to complete the course that the doctor prescribes, even if the symptoms disappear, or else the infection might recur. Do not double up the dosage to make up for a forgotten one, as an excess of this medicine can lead to overdosing.

This antibiotic can be harmful for children, breast-feeding mothers and pregnant women. Therefore, it is advisable for them not to take Levofloxacin. In some cases, for patients suffering from certain other conditions, it is advisable not to take Levofloxacin.

You should inform your doctor before beginning a prescription of Levofloxacin If you also suffer from conditions like-

Although this rarely occurs, it is possible, for you to have an allergy to Levofloxacin. An allergic reaction would cause symptoms such as hives, swollen lips, face or tongue, severe skin rashes, sore throat, rapid heart rate and difficulty breathing. It is advisable to stop taking this medicine immediately, if you experience the symptoms of an allergic reaction and consult with your doctor.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Internal Medicine Specialist before using this medicine.

The most common use of this medication is:

This medicine causes side effects such as:

  • How long is the duration of effect?

    This medicine is excreted largely in urine and the effect lasts for a duration of 16 to 20 hours.
  • What is the onset of action?

    The effect can be observed within 1 to 3 hours of administration of the dose.
  • Are there any pregnancy warnings?

    This medicine is generally not recommended for pregnant women and should only be used if clearly needed under the supervision of a doctor.
  • Is it habit forming?

    No habit forming tendency has been reported.
  • Are there any breast-feeding warnings?

    This medicine is not recommended for women who are breastfeeding as it affects the development of infant's joints. Use only if clearly needed under the supervision of a doctor. Monitoring of undesired effects like diarrhea, diaper rash is necessary.
  • Is It safe with alcohol?

    It is safe to consume alcohol with this medicine.
  • Is it safe to drive while on this medicine?

    This medicine affects the consciousness of the patient. Thus driving must be avoided while taking this medication.
  • Does this affect kidney function?

    Caution must be taken in patients with kidney disease. Adjustment of dose is needed. Kindly consult your doctor before taking it.
  • Does this affect liver function?

    Limited information is available regarding its use in patients with liver disease. Kindly consult your doctor before taking it.
  • Are there any missed dose instructions?

    If you miss a dose of Levofloxacin, take the missed dose as soon as you remember. If it's almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.
  • Are there any overdose instructions?

    Seek emergency medical treatment or contact the doctor in case of an overdose.
  • India

  • United States

  • Japan

Below is the list of medicines, which contains Levofloxacin as ingredient

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This medication belongs to the class fluoroquinolones. It works as a bactericidal by inhibiting the bacterial DNA gyrase enzyme, which is essential for DNA replication, transcription, repair, and recombination. This leads to expansion and destabilization of the bacterial DNA which causes cell death.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

  • Interaction with Alcohol

    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Interaction with Lab Test

    Evaluation of organ system functions (renal, hepatic, ophthalmologic, and hematopoietic) is recommended periodically during therapy; the possibility of crystalluria should be assessed; WBC and signs of infection
  • Interaction with Medicine

    • Antineoplastic agents may decrease the absorption of quinolones.
    • Cimetidine, and other H2 antagonists may inhibit renal elimination of quinolones.
    • Foscarnet has been associated with an increased risk of seizures with some quinolones.
    • Loop diuretics: Serum levels of some quinolones are increased by loop diuretic administration. May diminish renal excretion.
    • NSAIDs: The CNS stimulating effect of some quinolones may be enhanced, resulting in neuroexcitation and/or seizures.
    • Probenecid: Blocks renal secretion of quinolones, increasing concentrations.
    • Warfarin: The hypoprothrombinemic effect of warfarin is enhanced by some quinolone antibiotics. Levofloxacin does not alter warfarin kinetics, but may alter the gastrointestinal flora. Monitor INR closely during therapy.
  • Interaction with Disease

    Central Nervous System Depression

    You may experience tremors, restlessness, anxiety, confusion, hallucinations upon taking fluoroquinolones. Avoid using caffeine-containing products.


    Avoid taking this medicine if it results in severe diarrhea, abdominal pain, and blood in stools. Consult your doctor you are having any gastrointestinal diseases. Drink adequate amount of water to prevent dehydration.

    Qt Prolongation

    Avoid taking this medicine if you experience any discomfort in your chest. Regular cardiac function tests are to be performed if you have any heart disease (arrhythmia) or family history of heart disease.

    Kidney Disease

    Avoid using Levofloxacin if you experience abdominal pain, diarrhea and joint pain. The medicine accumulates in the body due to impaired kidney function, putting you at high risk. Regular kidney function tests are to me performed if you are on Levofloxacin. Appropriate dose adjustments are to be made under doctor's supervision.
  • Interaction with Food

    Information not available.

Ques: What is Levofloxacin?

Ans: Levofloxacin is a salt which performs its action by stopping the action of a bacterial enzyme called DNA-gyrase. This prevents the bacterial cells from dividing and repairing, thereby killing them. Levofloxacin is used to treat conditions such as Cystitis, Pyelonephritis, Nongonococcal Urethritis, Skin and structure Infection, Pneumonia, etc.

Ques: What are the uses of Levofloxacin?

Ans: Levofloxacin is a medication, which is used for the treatment and prevention from conditions such as Cystitis, Pyelonephritis, Nongonococcal Urethritis, Skin and structure Infection, and Pneumonia. Apart from these, it can also be used to treat conditions like Bronchitis, Inhalation Anthrax, and Plague. The patient should inform the doctor about any ongoing medications and treatment before using Levofloxacin to avoid undesirable effects.

Ques: What are the Side Effects of Levofloxacin?

Ans: Levofloxacin is a medication which has some commonly reported side effects. These side effects may or may not occur always and some of them are rare but severe. This is not a complete list and if you experience any of the below-mentioned side effects, contact your doctor immediately. Here are some side effects of Levofloxacin which are as follows: Diarrhea, Abdominal pain, Confusion, Fever, Redness of skin, Change in taste, Constipation, Dizziness, Headache, and Nausea or vomiting. It is a list of possible side-effects which may occur due to the constituting ingredients of Levofloxacin.

Ques: What are the instructions for storage and disposal Levofloxacin?

Ans: Levofloxacin should be kept in a cool dry place and in its original pack. Make sure this medication remains unreachable to children and pets. The patient should consult a doctor for its further uses and side effects and should inform the doctor about any ongoing medications and treatment before using to avoid undesirable effects. It is a prescribed medication.
Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

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Table of Content
About Levofloxacin
What are the uses of Levofloxacin
What are the contraindications of Levofloxacin ?
What are the side effects of Levofloxacin ?
Key highlights of Levofloxacin
What are the dosage instructions?
Where is the Levofloxacin approved?
Medicines containing Levofloxacin
How does this medication work?
What are the interactions of Levofloxacin ?
FAQs about Levofloxacin