Levofloxacin is a medicine that is a member of the fluoroquinolone antibiotic family. It fights against bacterial infections like tuberculosis, pneumonia, laryngitis, cellulitis, gastroenteritis, acute or chronic bronchitis, urinary tract infections, tonsillitis, anthrax and plague. This antibiotic also treats infections of the pelvis, kidney, prostate and skin.
Levofloxacin may also be used for uncomplicated skin and skin structure infection (due to S. aureus or S. pyogenes) and complicated urinary tract infection due to gram-negative Enterobacter sp, including acute pyelonephritis (caused by E. coli).
Levofloxacin works by killing the bacteria that are causing an infection. It hinders the process of cell replication and cell division, within the cell of the bacteria, by inhibiting the synthesis of the DNA gyrase enzyme. Without this enzyme, the cell of the bacteria cannot survive or grow. Hence, Levofloxacin behave as bactericide.
Levofloxacin fights against bacteria that are Gram-positive as well Gram-negative. This broad-spectrum antibiotic is effective in inhibiting the synthesis of enzymes called DNA gyrase, which is essential to the process of replication and division of bacterial cells. Thus, Levofloxacin inhibits the cell division of the bacteria, making it impossible for them to survive. This makes it effective in treating bacterial infections.
The doctor will prescribe instructions for taking Levofloxacin according to your condition, the severity of that condition and the other medications you are taking. It is important to complete the course that the doctor prescribes, even if the symptoms disappear, or else the infection might recur. Do not double up the dosage to make up for a forgotten one, as an excess of this medicine can lead to overdosing.
This antibiotic can be harmful for children, breast-feeding mothers and pregnant women. Therefore, it is advisable for them not to take Levofloxacin. In some cases, for patients suffering from certain other conditions, it is advisable not to take Levofloxacin.
You should inform your doctor before beginning a prescription of Levofloxacin If you also suffer from conditions like-
Although this rarely occurs, it is possible, for you to have an allergy to Levofloxacin. An allergic reaction would cause symptoms such as hives, swollen lips, face or tongue, severe skin rashes, sore throat, rapid heart rate and difficulty breathing. It is advisable to stop taking this medicine immediately, if you experience the symptoms of an allergic reaction and consult with your doctor.
How long is the duration of effect?This medicine is excreted largely in urine and the effect lasts for a duration of 16 to 20 hours.
What is the onset of action?The effect can be observed within 1 to 3 hours of administration of the dose.
Are there any pregnancy warnings?This medicine is generally not recommended for pregnant women and should only be used if clearly needed under the supervision of a doctor.
Is it habit forming?No habit forming tendency has been reported.
Are there any breast-feeding warnings?This medicine is not recommended for women who are breastfeeding as it affects the development of infant's joints. Use only if clearly needed under the supervision of a doctor. Monitoring of undesired effects like diarrhea, diaper rash is necessary.
Is It safe with alcohol?It is safe to consume alcohol with this medicine.
Is it safe to drive while on this medicine?This medicine affects the consciousness of the patient. Thus driving must be avoided while taking this medication.
Does this affect kidney function?Caution must be taken in patients with kidney disease. Adjustment of dose is needed. Kindly consult your doctor before taking it.
Does this affect liver function?Limited information is available regarding its use in patients with liver disease. Kindly consult your doctor before taking it.
Are there any missed dose instructions?If you miss a dose of Levofloxacin, take the missed dose as soon as you remember. If it's almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.
Are there any overdose instructions?Seek emergency medical treatment or contact the doctor in case of an overdose.
Below is the list of medicines, which contains Levofloxacin as ingredient
This medication belongs to the class fluoroquinolones. It works as a bactericidal by inhibiting the bacterial DNA gyrase enzyme, which is essential for DNA replication, transcription, repair, and recombination. This leads to expansion and destabilization of the bacterial DNA which causes cell death.
Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.
Interaction with Alcohol
Interaction with Lab Test
Interaction with Medicine
- Antineoplastic agents may decrease the absorption of quinolones.
- Cimetidine, and other H2 antagonists may inhibit renal elimination of quinolones.
- Foscarnet has been associated with an increased risk of seizures with some quinolones.
- Loop diuretics: Serum levels of some quinolones are increased by loop diuretic administration. May diminish renal excretion.
- NSAIDs: The CNS stimulating effect of some quinolones may be enhanced, resulting in neuroexcitation and/or seizures.
- Probenecid: Blocks renal secretion of quinolones, increasing concentrations.
- Warfarin: The hypoprothrombinemic effect of warfarin is enhanced by some quinolone antibiotics. Levofloxacin does not alter warfarin kinetics, but may alter the gastrointestinal flora. Monitor INR closely during therapy.
Interaction with Disease
Central Nervous System DepressionYou may experience tremors, restlessness, anxiety, confusion, hallucinations upon taking fluoroquinolones. Avoid using caffeine-containing products.
ColitisAvoid taking this medicine if it results in severe diarrhea, abdominal pain, and blood in stools. Consult your doctor you are having any gastrointestinal diseases. Drink adequate amount of water to prevent dehydration.
Qt ProlongationAvoid taking this medicine if you experience any discomfort in your chest. Regular cardiac function tests are to be performed if you have any heart disease (arrhythmia) or family history of heart disease.
Kidney DiseaseAvoid using Levofloxacin if you experience abdominal pain, diarrhea and joint pain. The medicine accumulates in the body due to impaired kidney function, putting you at high risk. Regular kidney function tests are to me performed if you are on Levofloxacin. Appropriate dose adjustments are to be made under doctor's supervision.
Interaction with Food
Ques: What is Levofloxacin?
Ques: What are the uses of Levofloxacin?
Ques: What are the Side Effects of Levofloxacin?
Ques: What are the instructions for storage and disposal Levofloxacin?
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