I am a 25 year old married. TTC since 1 year. My cycles are regular no weight gain. I did Usg scan which showed right sided polycystic ovary. I took clomifene citrate and duphaston for 3 months but nothing worked. Later I did follicular study in that my follicle dint get rupture even after HCg shot of 5000IU. Later I did hormonal checkup a week ago in which everything was normal except 2 things I. E. SHBG 24.21nmol/L and a bioavailability testosterone percentage 49.4%. I was worried after seeing this but I wanted to know the significance of these 2 hormones and whether this can be improved naturally and I also wanted to know does these 2 cause infertility? I also wanted to what medicine I can take to rupture my follicle.

Dr. Neelam NathGeneral Physician42yrs exp

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Duphaston is given to pregnant woman to retain pregnancy, it is progesterone hormone present in woman to give power for fertilisation and to retain embryo. It is released on 14th day of cycle, once follicle gets ruptured and egg is released, moves towards uterus for ferilization through fallopian tubes. If no pregnancy occurs like in unmarried girls, both hormones the feminizing estrogens and the masculining progesterone starts declining, becomes almost zero and cycle starts, if pregnancy occurs, there is a signal for both hormones to increase gradually. As an added security, for bad cases, duphaston (progesterone) is given to retain the embryo. By the way ipill has high doses of progesterone to stop pregnancy. I do not understand, how were you given clomifene (medicine ti increase the eggs) and duphaston together? now you have to wait for this hormone to come down, which it will on its own, being a fat soluble hormone, it may take few months for normal unaffected cycle to start and for natural follicles to erupt again. You can take syrup evecare 1 spoon per day. But remember no hormones and no erratic treatment for fertility at age 24, when nature is on your side. Regarding polycystic disease, you can take tablet metformin 500 mg /day. But forget getting pregnant till your cycle is normal and ultrasound shows normal follicles day 10 onwards which remain alive and keep growing till day 14, rupture around 48 hours later, doctors give medicines to make follicles strong and healthy. Do write back again. 

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