My wife is under treatment for below symptoms. 1) bi-polar (getting very angry and sleeplessness. Unwanted thoughts and concerns, body pain, phycatric disorder like doing abnormal activities which is difficult to justify in common sense. Talking irrelevant things. Loss of memory, lack of concentration. Weakness, she was in a depressed mood since a 1 to 1.5 years. Withdraw from others and not interested to interact with neighbours and even with relatives. Her tsh is 15. Medicine taking. Valprol-500, olimelt- 12.5 mg. And thyroxine- 50 mg. My question is that should she has to go with medicine for life time? Her condition is moderately improved since the treatment started from last month. How much time will take to get normal mentally and physically. Thanks, prasad.