I am a male of 57 years suffering from depression from last 25 years. I took many antidepressant medicines. From last two years I was taking zosert 50 mg. One at night and was feeling well, sleeping well. Now suddenly from last one month, I am very un happy, no interest in works and remain in my bedroom, not want to talk to anybody. Then I increased dose of zosert 50 gm to 100 gm up to 20 days but no progress, then I again increased the zosert 100 mg to 200 mg but no progress. At night I was also taking Ativan 2mg. For sleeping. I think I can never be happy again and can not work again. Kindly advise me accordingly as per above details.