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My sis have a habit of talking with herself, is dis sign of depression, what is the reason behind it.
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This is not a good sign especially if she is not aware of it. In fact it is more than depression and needs immediate attention. Take her to a counselor first and let that person assess the seriousness of her condition and if that person wants her to meet a psychiatrist, please do it soon. It is most likely that your sister will be unwilling to come claiming that she is alright. You must still insist and take her anyway.
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