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Rofiz 500 MG Tablet

Manufacturer: Wockhardt Ltd
Medicine composition: Rofecoxib
Prescription vs.OTC: Prescription by Doctor required

Rofiz 500 MG Tablet is an anti-inflammatory non-steroidal drug used to address various types of pain, particularly from menstrual cramps as well as osteoarthritis. Certain chemicals such as prostaglandins are the main cause behind the inflammation and its resulting symptoms of fever, pain, tenderness and swelling. This medicine blocks those enzymes that secrete prostaglandins, thus reducing inflammation. Rofiz 500 MG Tablet differs from NSAIDs in the way that they result in lesser ulceration and irritation of the intestine and the stomach and also doesn’t hamper the process of blood clotting.

Few common side effects associated with Rofiz 500 MG Tablet include headache, pain in the abdomen, dyspepsia, heartburn, diarrhea, nausea and retention of water by the body. Other less likely side effects include urinary retention, hypertension that aggravates, heart failure, pain in the chest, tinnitus, insomnia, intestinal and stomach ulcers, blurred vision, increase in weight, bleeding, fatigue, drowsiness and symptoms similar to flu. Allergies are also common with prolonged use of Rofiz 500 MG Tablet. Individuals who are susceptible to allergic reactions due to the intake of other NSAIDs should not take Rofiz 500 MG Tablet.

Rofiz 500 MG Tablet should be administered in low dosages. For managing osteoarthritis, usual dose of this medicine is about 12.5 mg, once daily with 25 mg being the maximum. The dosage is 50 mg (once daily) when it comes to managing acute pain that is a result of menstrual cramps.

Prolonged intake of Rofiz 500 MG Tablet along with aspirin or other non-steroidal anti- inflammatory drugs may induce side effects such as bleeding and ulceration of the intestinal lining. Since NSAIDs lead to an increase of lithium levels in the body, the body’s lithium concentration should be monitored prior to, during and post therapy.

Information given here is based on the salt and content of the medicine. Effect and uses of medicine may vary from person to person. It is advicable to consult a Rheumatologist before using this medicine.

Rofiz 500 MG Tablet is used to treat pain and swelling associated with Osteoarthritis.
Rofiz 500 MG Tablet is used for relieving swelling, stiffness, and pain of joints caused due to Rheumatoid Arthritis.
Rofiz 500 MG Tablet is also used for the symptomatic treatment of Ankylosing spondylitis. This disease causes swelling of the spine and large joints.
This medicine is not recommended for use if you are allergic to it or any other component of the medicine.

Peptic Ulcer

This medicine is not recommended if you have peptic ulcer or other conditions that cause swelling and bleeding of the stomach. It could cause severe swelling and bleeding in the stomach, colon, and anus as well.

Heart diseases

This medicine is not recommended for use in patients having a history of heart conditions. The risk of fatal adverse effects are even higher if you have an active condition like heart block, rhythm disorder etc.
In addition to its intended effect, Rofiz 500 MG Tablet may cause some unwanted effects too. In such cases, you must seek medical attention immediately. This is not an exhaustive list of side effects. Please inform your doctor if you experience any adverse reaction to the medication.


Moderate Less Common

Nausea or Vomiting

Moderate Less Common

Swelling of face, lips, eyelids, tongue, hands and feet

Major Less Common

Severe stomach ache

Major Less Common

Blurred vision

Moderate Less Common

Hives and wheezing

Major Common

Heart attack

Major Common

Kidney failure

Major Less Common

Liver disease

Major Less Common

Urinary tract infection

Moderate Less Common

How long is the duration of effect?

The effect of this medicine lasts for an average duration of 16-20 hours.

What is the onset of action?

The effect of this medicine can be observed within 1-3 hours of administration.

Are there any pregnancy warnings?

This medicine is not recommended for use if you are pregnant or planning a pregnancy in near future. Your doctor may prescribe a safer alternative if the use of a painkiller is absolutely necessary.

Is it habit forming?

No habit forming tendencies were reported.

Are there any breast-feeding warnings?

This medicine is not recommended for use if you are breastfeeding. Your doctor may prescribe a safer alternative if the use of a painkiller is absolutely necessary.

Missed Dose instructions

Take the missed dose as soon as you remember. The missed dose should be skipped if it is almost time for the next scheduled dose.

Overdose instructions

Contact your doctor immediately if an overdose is suspected. Symptoms of overdose may include skin rashes, confusion, chest pain, blurred vision etc.
Rofiz 500 MG Tablet is a non-steroidal anti-inflammatory drug which is used to treat osteoarthritis and dysmenorrhea. COX-2 regulates the synthesis of the prostaglandins which are responsible for inflammation and pain. Rofecoxib selectively inhibits COX-2 and relieves pain.
Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

Interaction with Disease

Heart Disease

This medicine should be used with extreme caution if you are suffering from any heart-related conditions. Report the incidence of stroke, heart attack or heart failure to the doctor before receiving this medication. Your doctor may prescribe a more suitable medicine based on the severity of the condition.

Liver Disease

This medicine should be used with extreme caution in patients having an active liver disease especially if the liver function is severely impaired. Suitable dose adjustment and safety monitoring may be required in such cases.

Gastro-intestinal disease

This medicine should be used with caution if you have any disease of the stomach or intestine. The risk of worsening of symptoms is very high while using this medicine. Report any such instance, whether historic or active, to the doctor.

Interaction with Alcohol


Restrict or minimize the use of alcohol while taking this medicine. Report any instances of heartburn or stomach discomfort like severe cramps and pain to the doctor on priority.

Interaction with Lab Test


Information not available.

Interaction with Food


Information not available.

Interaction with Medicine


Report the use of Lithium to the doctor before receiving Rofiz 500 MG Tablet. You may require a safety test to determine the levels of lithium in the body before taking Etoricoxib for appropriate dose adjustments.


Report the use of Ramipril or any other medication used for the treatment of hypertension to the doctor. You may require an adjusted dose of Rofiz 500 MG Tablet while using it together with the blood pressure medications. It is also advised to monitor the blood pressure levels on a regular basis.


Report the use of Warfarin to the doctor before receiving this medicine. You may require a dose adjustment based on the blood clotting time. Any symptoms like unusual bleeding, vomiting, the presence of blood in urine and stools should be reported to the doctor immediately.

Ethinyl Estradiol

Report the use of Ethinyl estradiol or any other oral contraceptive to the doctor. Your doctor may prescribe an adjusted dose of Ethinyl estradiol for coadministration with Etoricoxib.


Report the use of either of the medicine to the doctor. You may require an adjusted dose of Rofiz 500 MG Tablet and more frequent clinical monitoring of symptoms.
Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.
Table of Content
About Rofiz 500 MG Tablet
When is Rofiz 500 MG Tablet prescribed?
What are the contraindications of Rofiz 500 MG Tablet ?
What are the side effects of Rofiz 500 MG Tablet ?
Key highlights of Rofiz 500 MG Tablet
What are the dosage instructions?
Where is the Rofiz 500 MG Tablet approved?
How does medicine works?
What are the interactions for Rofiz 500 MG Tablet ?