Necessity is the mother of invention. Ironically, accidents to end up in discoveries. Sir Alexander Fleming accidentally discovered Penicillin in 1928. After many years of research and experiments, Penicillin eventually came into use during World War II. Though it’s believed to be a blessing, it has opened the doors for various allergic reactions and bacterial resistance over the period of time. About 10% of people report allergies to Penicillin, wherein more than 90% of these patients are found not to be allergic to Penicillin after skin testing.
Reactions to Penicillin:
Penicillin belongs to a family of antibiotics known as beta-lactams which also comprises of Penicillin G, Cloxacillin, Ampicillin, Amoxicillin, Piperacillin, and many more which are believed to be effective in eradicating common bacterial infections and relatively inexpensive.
The major problem in the use of Penicillin is hypersensitivity reactions. Your immune system can work wonders when encountered with any foreign body (antigen) by producing its antibody, which fights against the antigen. When your body is attacked by bacteria the lymphocytes (T-Cells) trigger the production of antibodies (immunoglobulin) to fight against the bacteria. However, in some people Penicillin administration can be considered as an invader and their immune system produces antibodies against it, thereby resulting in allergic reactions.
Acute and Sub - acute reactions:
You can observe two clinical pictures resulting from penicillin allergy:
Acute allergic reaction:
Sub-Acute allergic reaction:
Risk factors for IgE mediated reaction:
Watch out for:
While people are taking a Penicillin medication several different rashes can appear:
Other conditions resulting from Penicillin allergy:
In case you have a concern or query you can always consult an expert & get answers to your questions!