My 4 year old daughter has suffered with severe chronic constipation since birth. When she was born she was admitted in the neonatal for 9 days due to abdominal distention, feed intolerance, suspected sepsis, vomiting bright green bile and Meconium Ileus. She did not pass her meconium for 33 hours and it was passed due to a paediatrician giving her a suppository. It's now getting worse as she is getting older. She suffers with abdominal distention, leakages, agonising pain, passing a lot of gas and cannot walk sometimes due to the pain. She has been on 5 different laxatives (lactulose, movicol, docusate, sodium picosulfate and sennakot) now of them have worked and she has also had 2 enemas that did not work also. She has had a biopsy done for Hirschsprung's disease and it came back normal and all her bloods are normal as well. She is missing a lot of school due to this and her doctors don't seem to think it's serious but after all the medication she's had I think differently. She used to pass a stool and get some relief for a few weeks now it's just days till the pain starts all over again like she isn't getting any relief at all anymore. It can be 3 weeks before she passes a stool. I've done some research and seen that meconium ileus can be related to cystic fibrosis and I've seen that you can have it in the digestive system also. Could this be a possibility for her?