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I am a 40 years old male, weight: 51 kgs (ht. 5 ft 3 in). I am having high blood pressure since last 03 years. Presently under medication of cilnidipine 10 mg + nebivolol 2.5 mg once daily and my blood pressure is normal. But my serum uric acid often gets elevated for which I take febuxostat 40 mg. My cbc, lipid profile, liver panel, serum na, k values, fasting & pp bs, serum creatinine are all in normal range. Ecg impression is also quite normal, though 2d-echo shows mild left ventricular hypertrophy with diastolic dysfunction. My physician is advising me to switch to losartan 50 mg + cilnidipine 10 mg. What should be the best treatment for diastolic dysfunction/lvh? Should I switch to losartan-cilnidipine combination?
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Yes you can switch to losartan and cilnidipine. Losartan has benefits in reducing uric acid also. It will control bp and prevent remodeling of heart too. Adding cildnipine will further help to control bp by dilating blood vessels and reducing work load on heart. The mainstay of treatment for lvh with diastolic dysfunction is ace/arbs, diuretics, ccbs and beta blockers! beta blockers may later be added if needed!
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