Losartan is primarily prescribed for the treatment of hypertension with or without concurrent use of thiazide diuretics. It belongs to the angiotensin II receptor antagonists group of drugs. It prevents the blood vessels in your body from narrowing, thus lowering your blood pressure and improving the blood circulation.
This medication has the ability to lower the possible risk of a stroke in people suffering from any heart condition. Apart from that, it can also slow down kidney damage among people with type 2 diabetes. You can take this medicine with as well as without food. It can take 3-6 weeks for your blood pressure to come under control after you have started a course of this medication.
Losartan is a prescription drug that is available in the form of an oral tablet. There are three main reasons for its usage. Firstly, it is used for the treatment of high blood pressure. The second usage is for reducing the risk of stroke in people, who already have high blood pressure as well as left ventricular hypertrophy (LVH).
LVH is a condition where the left ventricle (chamber) of the heart thickens as a result of which the heart is unable to pump well. Lastly, Losartan is used for treating diabetic nephropathy, a kidney disease caused due to diabetes.
Losartan blocks the action of the chemical named angiotension II in the body, which causes the blood vessels to narrow and tighten. This medication helps the blood vessels to relax and eventually widen. It lowers your blood pressure, thus reducing your risk of having a stroke or kidney damage.
The dosage and the form of having Losartan depends on your age, severity of your condition, your medical history and also how your body reacts when you take the first dose. If you miss a dose, take it once you realize the missed dose. However, ensure that you do not take two doses at the same time just because you missed the previous one. Overdosing can make you feel dizzy, weak or a pounding heart.
There are some common side effects of Losartan that are generally mild and go away in a few days. They include:
There are some serious side effects too for consuming Losartan. In case you experience any of the following symptoms, you must consult the doctor immediately and seek medical help:
- If you experience problems in your heart rhythms, a slow heart rate or weakness in the muscles. It could be an indication of high potassium levels in your blood.
- Symptoms of swelling in the tongue, throat, lips or face; indicating an allergic reaction.
- Swelling in the ankles, feet, hand or sudden weight gain can be a sign of kidney problem. In case you are suffering from a kidney problem or disease, Losartan may worsen the condition.
Take exactly as directed; do not discontinue without consulting prescriber. Take first dose at bedtime. This drug does not eliminate need for diet or exercise regimen as recommended by prescriber.
May cause dizziness, fainting, lightheadedness (use caution when driving or engaging in tasks that require alertness until response to drug is known); diarrhea (buttermilk, boiled milk, yogurt may help).
Report chest pain or palpitations; unrelenting headache; swelling of extremities, face, or tongue; difficulty in breathing or unusual cough; flu-like symptoms; or other persistent adverse reactions.Type I diabetes
The primary use of this medication is as follows:
How long is the duration of effect?This medicine is excreted largely in faeces and the effect lasts for a duration of approximately 24 hours.
What is the onset of action?The peak effect of this medicine can be observed in 1 to 1.5 hours.
Are there any pregnancy warnings?This medicine is not recommended for pregnant women.
Is it habit forming?No habit forming tendency has been reported.
Are there any breast-feeding warnings?This medicine is not recommended for women who are breastfeeding.
Is It safe with alcohol?Caution must be taken while consuming alcohol during taking this medicine.
Is it safe to drive while on this medicine?This medicine may cause dizziness, thus patients ability to drive might get affected. Thus driving mst be avoided while taking this medicine.
Does this affect kidney function?None necessary. Kindly consult your doctor before taking it.
Does this affect liver function?Caution must be taken while using this medicine in patients with liver disease. Adjustment of dose is needed. Reduce the initial dose to 25 mg; divide dosage intervals into two. Kindly consult to doctor before taking it.
Are there any missed dose instructions?The missed dose should be taken as soon possible. It is advisable to skip the missed dose if it's already time for your next scheduled dose.
Are there any overdose instructions?Seek emergency medical treatment or contact the doctor in case of overdose.
Below is the list of medicines, which contains Losartan as ingredient
This medicine works by displacing angiotensin II with very high affinity from its binding site at the AT1 receptor subtype, which is responsible for the known actions of angiotensin II.
Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.
Interaction with Alcohol
Interaction with Lab Test
Interaction with Medicine
- Fluconazole (and possibly other azoles) decreases the plasma level of losartan's active metabolite; monitor for decreased efficacy.
- Lithium: Risk of toxicity may be increased by losartan; monitor lithium levels.
- Potassium-sparing diuretics (amiloride, potassium, spironolactone, triamterene): Increased risk of hyperkalemia.
- Potassium supplements may increase the risk of hyperkalemia.
- Rifampin may reduce antihypertensive efficacy of losartan.
- Trimethoprim (high dose) may increase the risk of hyperkalemia.
Interaction with Disease
Congestive Heart FailureLosartan is used with caution in patients with congestive heart failure especially in volume or sodium depletion. Transient hypotension is also not a contraindication to further treatment with AR antagonists, since therapy can usually be reinstated without difficulty after blood pressure stabilizes.
OthersAvoid use or use a smaller dose in patients who are volume depleted; correct depletion first. Deterioration in renal function can occur with initiation. Use with caution in unilateral renal artery stenosis and pre-existing renal insufficiency; significant aortic/mitral stenosis.
Interaction with Food
Ques: What is Losartan used for?
Ques: What is the onset of action of Losartan?
Ques: What is the duration of the effect of Losartan?
Ques: Should Losartan be taken with a meal or without a meal?
Ques: Where is Losartan approved?
Ques: Is Losartan safe for usage in paediatrics?
Ques: How is Losartan administered?
Ques: What are the storage indications of Losartan?
Tadalafil-Drug Information Portal [Internet].druginfo.nlm.nih.gov 2022 [Cited 25 May 2022].Available from:https://druginfo.nlm.nih.gov/drugportal/name/tadalafil
Tadalafil-DrugBank Online [Internet].go.drugbank.com 2022 [Cited 25 May 2022].Available from:https://go.drugbank.com/drugs/DB00820
TADALAFIL Tablet,solution-DailyMed [Internet].dailymed.nlm.nih.gov 2022 [Cited 25 May 2022].Available from:https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=TADALAFIL
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