26 years old female she is a 4th medical student. Diagnosed as depression, insomnia,generalised anxiety disorder with 4 episode of hyperventilating panic attacks for three years. Now she is suffering from severe throbbing headache on top of the head and occipital region also same time radiate to face and jaw. She see nightmares at every sleep that dream say people come to kill her in every nightmares. She is on mirtazapine ,and alprazolam. Headache is the problem. Not relieve by any pain medication. Only for sedatives but after wakeup pain is continuing. What we do for it.