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Is CEF is right chemo treatment nat ER +/PR + and Her 2- I am 41, unmarried, premenausal female. Diagnosed with Invasive breast cancer (lump on the right chest wall-upper inner quadrant high up) lymph node and axillary node positive. Type: ER +, PR+,her 2 -.Size of the tumor is 2.7 cm.and they say its a LABC (locally advanced breast cancer) .Started with NACT (CEF every 3 weekly). Done with the first chemo 15 days back with CEF (cyclophosphamide-750, epirubicin,-120 fluorouracil-750 mg. I am really confused as I don't see much data on hormone positive and Her 2 - patients given this CEF chemo (either adjuvant or neoadjuvant). My fellow patient (of similar types) from other hospitals are given AC/T. Also I met one of senior oncologist who suggested to shift from chemotherapy and instead start Neoadjuvant Endocrine Therapy (tamoxifen 20 mg for next 3 months). Would really appreciate if you share your expert opinion the right treatment path for my case.

2 Doctors Answered
If it's going to be breast preserving surgery then neoadjuvant is better. I giv TEC 3 cycles then surgery and then chemo TEC again, radiotherapy and then tamoxifen 2 years, then letrazol for 3 years and then tamoxifen forever EC / followed by T is what we now follow.
Hello Lybrate user! LABC means locally advanced breast cancer- decided not only with tumor size but also changes of breast skin, involvement of lymph nodes, and inflammatory changes. 3 cycles of FEC/ CEF or 4AC as neoadjuvant (chemotherapy before surgery) chemotherapy is good to give to reduce size of tumor and control local decease and also in cases of breast conservation surgeries. After surgery they might start TC as adjuvant chemotherapy (chemotherapy after surgery. So it is one of the treatment. Once neoadjuvant and adjuvant chemo will finish you have to take hormonal therapy.
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