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Mr. lybrate-user, Thanks for the query. Blood glucose 450 mg / 100 ml, is too high. The doctor is right in suggesting using of Insulin, because of very high blood glucose levels there is an effect called Glucotoxicity which makes pancreatic beta cells unresponsive, plus it also leads to increased insulin resistance. Plus there is also lipotoxicity because in this situation lipid metabolism is also damaged. In such a situation using Insulin for a short period of 3 to 4 months, helps in bringing down the glucose level rapidly and stabilising it. Later you may shift on to oral drugs. So now you should consider using Insulin along with oral drugs. Thanks.
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