Most antidepressants work more or less at the same level. Mostly, you go by the side-effects - whether they are acceptable by you. Both Vilazodone
have minimal sexual side effect. Fluoxetine
has more erectile dysfunction.
Weight and sedation are also to be taken into account. If you can tolerate effective dose of TCA, you can try. Otherwise go for Venlafaxine
. The only tip is - it is not the antidepressant. It is the duration (minimum 3-6 weeks) and dose (TCA and Venlafaxine 75 - 225 mg) of the tablet that matters.