Common Specialities
{{speciality.keyWord}}
Common Issues
{{issue.keyWord}}
Common Treatments
{{treatment.keyWord}}

Overview

Mainstay 50 MG Tablet

Mainstay 50 MG Tablet

Manufacturer: Gold Line
Medicine composition: Losartan
Prescription vs.OTC: Prescription by Doctor required

Table of Content

About Mainstay 50 MG Tablet
When is Mainstay 50 MG Tablet prescribed?
What are the contraindications of Mainstay 50 MG Tablet?
What are the side effects of Mainstay 50 MG Tablet?
Key highlights of Mainstay 50 MG Tablet
What are the substitutes for Mainstay 50 MG Tablet?
What are the dosage instructions?
Where is the Mainstay 50 MG Tablet approved?
What are the interactions for Mainstay 50 MG Tablet?

Mainstay 50 MG Tablet belongs to the angiotensin II receptor antagonists group of drugs. It prevents the blood vessels in your body from narrowing, thus lowering your blood pressure and improving the blood circulation. This medication has the ability to lower the possible risk of a stroke in people suffering from any heart condition. Apart from that, it can also slow down kidney damage among people with type 2 diabetes. You can take this medicine with as well as without food. It can take 3-6 weeks for your blood pressure to come under control after you have started a course of this medication.

Mainstay 50 MG Tablet is a prescription drug that is available in the form of an oral tablet. There are three main reasons for its usage. Firstly, it is used for the treatment of high blood pressure. The second usage is for reducing the risk of stroke in people, who already have high blood pressure as well as left ventricular hypertrophy (LVH). LVH is a condition where the left ventricle (chamber) of the heart thickens as a result of which the heart is unable to pump well. Lastly, Mainstay 50 MG Tablet is used for treating diabetic nephropathy, a kidney disease caused due to diabetes.

Mainstay 50 MG Tablet blocks the action of the chemical named angiotension II in the body, which causes the blood vessels to narrow and tighten. This medication helps the blood vessels to relax and eventually widen. It lowers your blood pressure, thus reducing your risk of having a stroke or kidney damage.

The dosage and the form of having Mainstay 50 MG Tablet depends on your age, severity of your condition, your medical history and also how your body reacts when you take the first dose. If you miss a dose, take it once you realize the missed dose. However, ensure that you do not take two doses at the same time just because you missed the previous one. Overdosing can make you feel dizzy, weak or a pounding heart.

There are some common side effects of Mainstay 50 MG Tablet that are generally mild and go away in a few days. They include:

  • Stuffy nose
  • Back pain
  • Diarrhea
  • Fatigue and dizziness
  • Pain in the chest
  • High/low blood pressure

There are some serious side effects too for consuming Mainstay 50 MG Tablet. In case you experience any of the following symptoms, you must consult the doctor immediately and seek medical help:

  • If you experience problems in your heart rhythms, a slow heart rate or weakness in the muscles. It could be an indication of high potassium levels in your blood.
  • Symptoms of swelling in the tongue, throat, lips or face; indicating an allergic reaction.
  • Swelling in the ankles, feet, hand or sudden weight gain can be a sign of kidney problem. In case you are suffering from a kidney problem or disease, Mainstay 50 MG Tablet may worsen the condition.
type diabetes
Mainstay 50 MG Tablet is used in the treatment of Hypertension which is an increase in the blood pressure caused by genetic and environmental factors.
Diabetic Nephropathy
Mainstay 50 MG Tablet is used in the treatment of diabetic Nephropathy which is a type of kidney disease which occurs due to high blood glucose.
Avoid if you have a known allergy to Mainstay 50 MG Tablet or any medicine of the same class.
Aliskiren
Use of these medicines is not recommended in the elderly population with diabetes and kidney disease with CrCl less than 60 ml/min.
In addition to its intended effect, Mainstay 50 MG Tablet may cause some unwanted effects too. In such cases, you must seek medical attention immediately. This is not an exhaustive list of side effects. Please inform your doctor if you experience any adverse reaction to the medication.
Stomach pain Major Common
Chills Major Common
Difficulty or painful urination Major Common
Fast heartbeat Major Common
Back pain Major Common
Chest tightness Major Rare
Dizziness Major Rare
Weakness in arms, hands, legs or feet Major Rare
Nasal congestion Minor Common
Sore throat Minor Common
Acid or sour stomach Minor Less Common
Heartburn Minor Less Common
How long is the duration of effect?
This medicine is excreted largely in faeces and the effect lasts for a duration of approximately 24 hours.
What is the onset of action?
The peak effect of this medicine can be observed in 1 to 1.5 hours.
Are there any pregnancy warnings?
This medicine is not recommended for pregnant women.
Is it habit forming?
No habit forming tendency has been reported.
Are there any breast-feeding warnings?
This medicine is not recommended for women who are breastfeeding.
Below is the list of medicines, which have the same composition, strength and form as Mainstay 50 MG Tablet, and hence can be used as its substitute.
Macleods Pharmaceuticals Pvt.Ltd
Cadila Pharmaceuticals Ltd
Lupin Ltd
Intas Pharmaceuticals Ltd
Ipca Laboratories Pvt Ltd.
Are there any missed dose instructions?
The missed dose should be taken as soon possible. It is advisable to skip the missed dose if it's already time for your next scheduled dose.
Are there any overdose instructions?
Seek emergency medical treatment or contact the doctor in case of overdose.
India
United States
Japan
Whenever you take more than one medicine, or mix it with certain foods or beverages, you're at risk of a drug interaction.
Interaction with Disease
Congestive heart failure Moderate
Mainstay 50 MG Tablet is used with caution in patients with congestive heart failure especially in volume or sodium depletion. Transient hypotension is also not a contraindication to further treatment with AR antagonists, since therapy can usually be reinstated without difficulty after blood pressure stabilizes.
Interaction with Alcohol
Alcohol Moderate
Consumption of alcohol with this medicine will lower the blood pressure and can cause dizziness, headache, changes in heart rate. Avoid driving or operating heavy machinery if you have these symptoms.
Interaction with Lab Test
Lab
Information not available.
Interaction with Food
Food
Information not available.
Interaction with Medicine
Aliskiren Major
Use of these medicines is not recommended especially in the elderly population with diabetes and kidney disease with CrCl less than 60 ml/min. You experience weakness, confusion, and irregular heartbeat if these medicines are taken together. Regular monitoring of blood pressure and kidney function tests are to be performed. An alternate medicine should be considered under the doctor's supervision.
Captopril Major
Use of these medicines is not recommended as it may increase the risk of kidney impairment and low blood pressure. You may experience weakness, confusion, and irregular heartbeat if these medicines are taken together. Regular monitoring of blood pressure and kidney function tests are to be performed. An alternate medicine should be considered under the doctor's supervision.
Dexamethasone Moderate
The desired effect of Mainstay 50 MG Tablet will not obtain if these medicines are taken together. This interaction is more likely to happen if dexamethasone is taken for more than 1 week. Inform the doctor if you have a sudden weight gain, swelling of hands and feet. If coadministration is needed then appropriate dose adjustments are to be made under the doctor's supervision. Regular monitoring of blood pressure and kidney function tests are to be performed.
Diclofenac Moderate
The desired effect of Mainstay 50 MG Tablet will not obtain if these medicines are taken together. The risk of kidney impairment will increase if these medicines are taken together especially in elderly population or having pre-existing kidney disease. Inform the doctor if you have an increased or decreased urination and unexplained weight gain or weight loss. Regular monitoring of blood pressure and kidney function tests are to be performed.
Insulin Moderate
The effect of insulin will increase if these medicines are taken together. You may experience dizziness, headache, sweating if these medicines are taken together. Regular monitoring of blood glucose levels is needed. Suitable dose adjustments or an alternate medicine should be considered under the doctor's supervision.

Popular Questions & Answers

My mother having pain I think she is suffering from arthritis please suggest me medication.

ms orthopaedics, mbbs
Orthopedist, Noida
My mother having pain I think she is suffering from arthritis please suggest me medication.
Try: 1. Regular knee quadriceps exercises (static and knee bending). 2. Ice pack application will help 3.Medications like Cartigen DN and Enzomac forte will help. Get weight bearing knee X-rays to stage the disease. Intrarticular injections offer great pain relief. Physical exercises are the mainstay of arthritis treatment. Avoid squatting or cross-legged sitting.
2 people found this helpful

Benefits and side effects of omega 3 tablet. Should I take these if I am pregnant.

M.B.B.S, Post Graduate Diploma In Maternal & Child Health
Gynaecologist, Bokaro
Benefits and side effects of omega 3 tablet. Should I take these if I am pregnant.
There is no harm in taking these pills. Yet, the mainstay of nutrition should be good nutritious food.

I am 37 years old and 11 years ago my uterus was removed. And now my weight is 85 kg. And I wanna lose my weight. So please guide me to lose my weight.

PG - Diploma in Dietetics & Nutrition, PG - Diploma in Clinical Research
Dietitian/Nutritionist, Nagpur
I am 37 years old and 11 years ago my uterus was removed. And now my weight is 85 kg. And I wanna lose my weight.
So ...
Tips. Feast on colorful foods. Fill your plate with vibrant fruits and veggies -- red, orange, yellow, and deep green. These are packed with disease-fighting antioxidants and fiber and should be the mainstay of your diet. Get plenty of grains & legumes. Whole grains like oatmeal, brown rice, whole-wheat pasta and cereals are all great high-fiber options. Black, red, and kidney beans are high in fiber and antioxidants. Choose proteins & fats wisely. You need to avoid  saturated fats, like fats found in butter, margarine, salad dressing, fried foods, snack foods, sweets. Vegetable oils (like olive oil and peanut oil) are good fats. Get enough calcium. For bone health, get at least 1,200 mg of calcium daily, plus vitamin D. Take milk and milk products. Daily.
1 person found this helpful

What is the proper treatment for sweets syndrome for the 3 years baby suffering from 3 months. Is it curable permanently. How much time it can take.

C.S.C, D.C.H, M.B.B.S
General Physician, Alappuzha
What is the proper treatment for sweets syndrome for the 3 years baby suffering from 3 months. Is it curable permanen...
The treatment of Sweet syndrome is directed toward the specific symptoms that are apparent in each individual. In some cases, Sweet syndrome may resolve itself with no treatment, although this can take weeks to months. The mainstay of treatment is with systemic corticosteroids. In most cases, treatment with low doses of corticosteroids such as methylprednisolone or prednisone has proven effective in eliminating symptoms, sometimes rapidly resolving symptoms. However, Sweet syndrome often recurs periodically despite therapy. For isolated lesions, local therapy may consist of topical corticosteroids (creams of gels) or directly injecting corticosteroids into the lesion (intralesional corticosteroid).
1 person found this helpful

I am 35 years old, I got depressed from 15 years, in this day I can't got any fever, any sneezing, but I have got several times cold . I don't know when I get well. Please help me. And clear my concept.

Masters In Clinical Psychology
Psychologist, Pune
I am 35 years old, I got depressed from 15 years, in this day I can't got any fever, any sneezing, but I have got sev...
Clinical Depression A mental health disorder characterized by persistently depressed mood or loss of interest in activities, causing significant impairment in daily life. Very common More than 10 million cases per year (India) Medium-term: resolves within months Requires a medical diagnosis Lab tests or imaging not required Possible causes include a combination of biological, psychological and social sources of distress. Increasingly, research suggests that these factors may cause changes in brain function, including the altered activity of certain neural circuits in the brain. The persistent feeling of sadness or loss of interest that characterizes major depression can lead to a range of behavioural and physical symptoms. These may include changes in sleep, appetite, energy level, concentration, daily behaviour or self-esteem. Depression can also be associated with thoughts of suicide. The mainstay of treatment is usually medication; talk therapy or a combination of the two. Increasingly, research suggests that these treatments may normalize brain changes associated with depression. Symptoms Requires a medical diagnosis the persistent feeling of sadness or loss of interest that characterizes major depression can lead to a range of behavioural and physical symptoms. These may include changes in sleep, appetite, energy level, concentration, daily behaviour or self-esteem. Depression can also be associated with thoughts of suicide. People may experience: Pain areas: in the back Mood: anxiety, apathy, general discontent, guilt, hopelessness, loneliness, loss of interest, loss of interest or pleasure in activities, mood swings, panic attack, sadness, or emotional distress Behavioral: agitation, excessive crying, irritability, restlessness, self-harm, or social isolation Sleep: early awakening, excess sleepiness, insomnia, or restless sleep Whole body: excessive hunger, fatigue, or loss of appetite Cognitive: lack of concentration, slowness inactivity, or thoughts of suicide Psychological: depression or repeatedly going over thoughts Also common: constipation, headache, and poor appetite, substance abuse, or weight loss.
1 person found this helpful

Popular Health Tips

Diet and Penis Function May Be Related

MD - General Medicine
Sexologist, Delhi
Diet and Penis Function May Be Related

There's a lot of truth in the old adage "you are what you eat," as it indicates that the food a person consumes has much more of an impact than simply sating the appetite. As surprising as it may seem, diet can indeed have an effect on a guy's penis health, including his penis function. And since the penis is one part of the body that a man clearly wants to keep functioning at the highest possible level, it's worth looking at how diet might affect penis function.

A study

Scientists recently conducted a study which was published in the journal Sexual Medicine Reviews. Entitled, "Diet and Men's Sexual Health," it looked at existing studies into this area published between 1977 and 2017 and aggregated the findings. They looked especially at various kinds of diets to determine if they seemed to have an impact on penis function, testosterone levels, and semen health. These studies indicated that men who had penis function issues usually benefited from following a Mediterranean diet. Obese men who followed a non-Western diet also usually had improvements in penis function due to the weight they lost.

Which diet?

The various diets are basically defined as follows:

- Mediterranean. A diet in which there is an emphasis on fish, monosaturated fats, fruits, vegetables, nuts and whole grains.

- Western. In this diet, there's more emphasis on red and processed meats, dairy, refined grains, and artificial sweeteners, and not much emphasis on fruits and vegetables.

- Paleolithic. Lean meats, fruits and vegetables are the mainstays of a Paleolithic diet. There is much less emphasis on dairy, sugar, salt and grains.

- Vegetarian/vegan. As the name implies, these are diets in which there are little or no animal products.

While these diets are presented in broad definitions, in general the diet which allows an individual man to be at his healthiest and at his most appropriate weight level and level of fitness is the diet that is best for him.

Beyond the kind of diet which impacts penis function, there are some other dietary factors which come into play.

For example, excessive intake of alcohol is generally associated with poor penis function. A moderate amount may prove beneficial to overall health, but too much alcohol is definitely a detriment to good sexual health.

By the same token, eating too much chocolate can lead to obesity, which is not good. But chocolate does have flavonoids, which can help increase blood flow, which is essential for good penis function. So consuming an appropriate quantity of chocolate may be good for some men. Watermelon also can be an aid in relaxing blood vessels.

Cashew nuts are high in zinc, and this can be a good thing for many men. Because zinc keeps testosterone from breaking down, consuming cashews may help maintain testosterone at a higher level, which tends to keep the sex drive up. Another good source of zinc: shitake mushrooms.

Sometimes it takes experimentation to learn exactly what parts of and kinds of a diet can impact a specific man's penis function. Another boost to better penis health is the daily application of a top notch penis health crème (health professionals recommend Man1 Man Oil, which is clinically proven mild and safe for skin). Look for a crème that contains two key amino acids - L-arginine and L carnitine. L-arginine helps in the production of nitric oxide, which is part of the process by which penile blood vessels remain open to increased blood flow. L carnitine is blessed with neuroprotective properties. When the penis is handled too roughly, it can cause a loss of sensation - and L carnitine helps to keep the penis feeling properly sensitized.

1 person found this helpful

High Cholesterol Level - Can It Cause Carotid Disease?

MCh, MBBS, MRCS (UK)
Neurosurgeon, Chennai
High Cholesterol Level - Can It Cause Carotid Disease?

Carotid artery disease occurs when an oily, waxy substance called plaque builds up inside the carotid arteries. These are arteries that supply oxygenated blood to your brain, face, scalp, and neck.
Carotid artery disease is very serious as it can cause a brain stroke. It, in fact, starts with damage to the inner layer of the carotid artery. To stem this damage your body starts a healing process and this leads to a build up of plaque at the point where the artery is damaged.

When this plaque ruptures, platelets are rushed in and these create an obstruction to the flow of blood to the brain. When the blood supply to the brain is cut off, which happens in carotid disease, the brain cells begin to die causing a stroke. This neural death impairs the parts of the body that these brain cells control. So, you can get paralyzed, become speech or vision impaired, have long –term effects like paralysis or even die due to a stroke.

Causes of carotid disease

  1. Smoking
  2. High cholesterol levels
  3. High blood pressure
  4. High levels of sugar in the blood due to diabetes

What’s even more worrisome is that carotid artery disease may not cause any signs or symptoms until the carotid arteries are severely narrowed or blocked. And what usually happens is that a stroke becomes the first sign of the disease.

How scary is that?
So, the next question that comes to the mind is - Can this condition be cured? Let’s learn more about management and prevention of the same-

Prevention
Lifestyle changes are key. Since hypertension, uncontrolled diabetes, sedentary lifestyles and imbibing too much fat are all risk factors, taking care of them minimizes the risk of carotid disease and strokes. Heart healthy lifestyle changes that include moderate exercise are a great way to prevent carotid disease.

Treatments
Treatments for carotid artery disease include:

Medicines: Sometimes lifestyle changes do not stem the rot. You need medicinal help. Doctors usually prescribe statin medications to control your cholesterol levels. These lower the bad cholesterol that can narrow your carotid arteries and cause brain strokes and damage. Statins are usually prescribed for people who have:

  • Heart disease
  • Those who’ve had a stroke
  • Diabetes
  • High LDL or bad cholesterol levels

Medicines like Aspirin and Clopidogrel to prevent blood clots are the mainstay treatment if you suffer from carotid disease. They prevent platelets from clumping together inside your carotid arteries and forming blood clots. Apart from these, your doctor may also medicate you for conditions that can damage your carotid arteries and cause strokes. These medicines are for lowering your BP, blood sugar levels, preventing the formation of blood clots anywhere in your body including inside your heart, and preventing and reducing inflammation.

Medical Procedures
These are used to open narrowed or blocked carotid arteries.
The two common procedures are:
Carotid endarterectomy: It’s mainly for people whose carotid arteries are blocked 50 percent or more. In this, the inner lining of the carotid artery that is blocking blood flow is removed.
Carotid artery angioplasty and stenting: Here, doctors use a procedure called angioplasty to widen the blocked carotid arteries and restore blood flow to the brain. A stent is inserted into your carotid artery to broaden the lumen.

In case you have a concern or query you can always consult an expert & get answers to your questions!

3582 people found this helpful

Gastroesophageal Reflux Disease - How Best Can You Manage It?

MD-General Medicine, D.M, Gastroenterology & Hepatology
Gastroenterologist, Ahmedabad
Gastroesophageal Reflux Disease - How Best Can You Manage It?

GERD or gastroesophageal reflux disease is a chronic digestive disease which occurs when the stomach acid and at times the contents in your stomach flows backwards into the food pipe. The backwash or reflux irritates the esophagus's lining and hence causes GERD. Individuals may manage GERD's discomfort by changing their lifestyle and by taking over-the-counter or OTC medications. But, certain people might also require stronger medications or surgery for reducing the symptoms.

Some of the basic signs include chest pain, burning sensation in the chest, dry cough, difficulty in swallowing, sore throat, etc. If you experience such symptoms at least twice a week or if your physician notices damage in your food pipe, then you might undergo diagnosis. Though drugs are the primary GERD treatment yet, an individual can manage it by following certain tips which may give relief.

Few ways to manage GERD- self-care tips:

  1. One of the effective ways to help yourself is by consuming smaller meals. Instead of taking three big meals regularly, you may try having smaller meals frequently and avoid stuffing.
  2. Almost all individuals tend to have dinner just half an hour before sleep, but this might affect GERD patients. It is best to eat 2 hours before going to bed as by doing so your stomach will get enough time to digest the food.
  3. Due to a hectic schedule and fast paced lifestyle, people tend to eat as quickly as possible. To manage GERD, one must eat slowly and put down the spoon or fork in between each bite.
  4. Changing the daily diet by striking off the trigger foods is beneficial in managing GERD symptoms. Though the food triggers vary from one person to another yet, it includes coffee, chocolate, peppermint, alcohol, tomato, citrus juices, onions, spicy and high- fat foods, etc.
  5. Sleeping with the head end of the bed elevated by 6 inches is a very effective way of reducing night time reflux. It is also advisable to sleep on your left side . Never sleep on the right side as this position promotes reflux. Medications to reduce acid production are the mainstay of the medical treatment.
  6. One always has to ensure that they are following the various lifestyle changes along with the medication. Other medications include pro kinetic medicines which help the stomach empty. Surgery always remains the last resort in the treatment of GERD. Endoscopy is required for the diagnosis or GERD Prior to any surgery a Manometry and 24 hr ph merry test is compulsory.

If you are suffering from GERD symptoms frequently, then you may maintain a diary for figuring out which foods are giving you trouble.

When is a surgery required?
If lifestyle changing tips and other medications fail to provide any relief, then physicians recommend undergoing surgery.

  • Surgery is done for strengthening lower esophageal sphincter and also for reinforcing it. The surgery for reinforcing lower esophageal sphincter is performed by surgeons laparoscopically. The surgeon inserts instruments like a tiny camera and flexible tube by making 3-4 incisions in the abdomen. This surgery for managing GERD may be quite effective.
  • Experts state that candidates who undergo GERD surgery are those who are unwilling to take GERD drugs or are not getting relief from them. While choosing a surgeon, it is better to consider one who possesses huge experience of the particular operation which you need and also with a good track record.
  • So, you must visit a doctor if you experience frequent gastroesophageal reflux disease symptoms. It won't be a good decision to take OTC medications without your doctor's recommendation if you notice arm or jaw pain along with difficulty in breathing as these are signs of heart attack.

In case you have a concern or query you can always consult an expert & get answers to your questions!

1847 people found this helpful

Suffering From Stomach Flu - Things You Must Know!

Bachelor of Unani Medicine and Surgery (B.U.M.S)
General Physician, Delhi
Suffering From Stomach Flu - Things You Must Know!

Gastroenteritis or  stomach flu is one of the commonest stomach infections in us, humans. It occurs due to infection by different viruses like the norovirus, which spread due to contaminated food. Its symptoms can be quite nasty- You may feel nauseous, have fever, fatigue, bloating, stomach pain, chills, diarrhoea and muscle aches and pains. And depending on the type of virus you have, stomach flu can last from one to 10 days. But is there a way to cull this stomach bug? Yes, more than one.

Read on to know more

  1. Drinking the right fluids is key to fast recovery: Fluids are critical for recovery from gastroenteritis because you’re losing vital body fluids through vomiting and diarrhoea. The right fluids are clear liquids like water and broth. Electrolyte containing drinks like sports drinks are pretty useful and so is ginger tea as ginger has anti-microbial qualities and helps with nausea. Peppermint tea helps calm your stomach. What not to drink? 
    • Coffee
    • Black tea
    • Chocolate
    • Any drink with drink with caffeine is contraindicated when a stomach bug bites. Caffeine affects sleep and a good night’s sleep is important for a full recovery.
    • Alcohol should also be strictly avoided as it’s a diuretic and can dehydrate you further.
  2. Stick to BRAT diet: The BRAT diet i.e bananas, rice, applesauce, and toast should be your mainstay during stomach flu. The diet has foods that are super easy to digest, contain a lot of carbohydrates to give you energy and provide you nutrients which you’ve lost through vomiting and diarrhoea.
    • Bananas: Bananas are easy to digest and replace lost nutrients like potassium. They also strengthen stomach lining.
    • Rice: Avoid brown rice as it has too much fibre, but white rice is good for sensitive stomach and provides energy from carbohydrates.
    • Applesauce: Provides energy due to carbs and sugars, and also contains pectin to help control diarrhoea.
    • Toast: Avoid whole-wheat bread because fibre is difficult to digest. White bread is easier to digest.
    • What to avoid?
      • Milk and curd are both to be avoided as they are hard to digest.
      • Fibre containing foods: When your bowels are loose, you don’t need the extra fibre.
      • Salty and oily foods like rich curries.
      • Do away with tomato sauces, tomato-based dishes, curries, and chillies.
  3. Rest: Rest is required to fight off the stomach bug. It’s better if you reduce your activities during the day.
  4. Medications: Stomach flu lasts for a maximum of 10 days and medicines like antibiotics don’t help as they can’t fight a virus. You can take medicines to help control symptoms of the problem, but you should do so sparingly. Like you can take ​​ibuprofen for fever, headache, or muscle aches. Tylenol can also relieve fever and aches and has fewer side effects than ibuprofen and is easier on your stomach. In case you have a concern or query you can always consult an expert & get answers to your questions!
4833 people found this helpful

Klatskin Tumour - Understanding It In Detail!

MD, MBBS
Oncologist, Ernakulam
Klatskin Tumour - Understanding It In Detail!

A fifty-four years old Marwari patient from Assam presented with progressive jaundice and intermittent episodes of abdominal pain for three months. CT scan of abdomen showed a small (1.5 x 1.5 cm) mass in the bifurcation of common bile duct which is causing biliary tract obstruction and hence jaundice. Portal nodes were not enlarged and there was no lesion in the liver parenchyma. At presentation, serum bilirubin level was high (14.7 mg/dl). Endoscopic biopsy and brushing cytology was adenocarcinoma and clinic-radiological diagnosis was ‘Klatskin tumour’. 

  • Metallic stenting was done to relieve jaundice and after stenting serum bilirubin level came down rapidly. PET scan showed increased uptake in the biliary duct region mass without any sign of metastasis. He was evaluated and planned for treatment with robotic radiosurgery. He was treated using robotic radiosurgery (CyberKnife) with high precision radiotherapy technique after fiducial placement (gold seeds) near the tumour. After one year, the patient had no obvious complain, liver function (no jaundice) was normal and CT scan evaluation showed completed resolution of the mass.  
  • Klatskin tumour is an uncommon tumour that arises from the bifurcation of common bile duct in the abdomen (duct that drains bile from liver). Patients usually present with progressive (increasing) persistent jaundice followed by pain in the upper abdomen. Surgical excision is the mainstay of treatment. However, surgery is not possible in majority of the patients owing to the location of the tumour, high jaundice and medical condition. Chemotherapy may not be an optimal option in majority of the patients as they present with high jaundice. Majority of such patients with poor medical condition are treated with only supportive care and prognosis is dismal (survival for a few months only).
  • Patients with metallic stent have relief from jaundice but unfortunately in a few weeks time, the stent gets blocked with tumour growth. Patients again present with high jaundice and have severely impaired quality of life. They complain of severe itching of entire body, loss of appetite and succumb due to impaired liver function from high jaundice/obstruction. The treatment is to have a longer ‘jaundice-free period’ which in turn improves quality of life and possibly survival function as well.  
  • Stereotactic body radiation therapy’s high dose radiation ‘sterilizes’ the metallic stent and bile duct region. It is assumed that with radiation therapy, blockage of bile duct and stent is delayed and patients have longer jaundice-free period.In Klatskin tumour, CyberKnife allows to deliver high dose of radiation in a short duration to the target without significant morbidity. If you wish to discuss about any specific problem, you can consult an Oncologist.
3107 people found this helpful

Table of Content

About Mainstay 50 MG Tablet
When is Mainstay 50 MG Tablet prescribed?
What are the contraindications of Mainstay 50 MG Tablet?
What are the side effects of Mainstay 50 MG Tablet?
Key highlights of Mainstay 50 MG Tablet
What are the substitutes for Mainstay 50 MG Tablet?
What are the dosage instructions?
Where is the Mainstay 50 MG Tablet approved?
What are the interactions for Mainstay 50 MG Tablet?