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Prescription vs.OTC: Prescription by Doctor required
Last Updated: October 22, 2020

Duloxetine is commonly used for treating generalized anxiety disorder, major depressive disorder, nerve pain associated with diabetes, fibromyalgia pain and chronic muscle or joint pain. Belonging to the drug group known as serotonin and norepinephrine reuptake inhibitors, the medication balances the chemicals in the brain causing anxiety and depression.

Apart from that, it also inhibits the pain signals from the nerves to the brain. Duloxetine is available in capsule form, to be taken orally. You can take it with food or without it. However, it is better to take it with food to prevent nausea. The dosage depends on your age, health condition and how your body responds to the treatment.

The doctor may prescribe a small dose initially and then increase it gradually. Ensure to take your doses regularly to get the benefit. If you miss a dose you can take it later, but do not take multiple doses at once to make up for the missed ones. Overdose of Duloxetine can lead to toxic side effects.

The common side effects of Duloxetine include nausea, dry mouth, fatigue, dizziness, sleepiness, constipation and loss of appetite. However, there may be some severe side effects too that require immediate medical attention:

  • Dark urine, yellowing of the skin, pain in the upper right abdomen; indicating a liver damage
  • Changes in your blood pressure level
  • Agitation, tremors, seizures or hallucinations
  • A serious skin reaction resulting in rashes, peeling of skin, blisters, hives
  • Vision problems like eye pain, change in vision, swelling or redness around the eyes
  • Headache, weakness or confusion; indicating low level of sodium in the blood

Avoid alcohol while you are prescribed to Duloxetine. Also, the medicine can make you feel drowsy or sleepy. Therefore, it is better to avoid driving or any other activity that requires your full concentration until you are sure how your body reacts to the medicine.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Psychiatrist before using this medicine.

The primary use of this medication is as follows:

  • Major Depressive Disorder

  • Anxiety

  • Diabetic Peripheral Neuropathy

  • Chronic Musculoskeletal Pain

  • Fibromyalgia

  • Allergy

  • Monoamine oxidase inhibitors

Side effects that can occur because of consuming this medication are:

  • How long is the duration of effect?

    The effect of this medicine lasts for an average duration of 24 hours.
  • What is the onset of action?

    The peak effect of this medicine can be observed in 6 to 10 hours.
  • Are there any pregnancy warnings?

    This medicine is not recommended for use during pregnancy unless absolutely necessary. Consult your doctor about the potential benefits and risks before deciding to take this medicine.
  • Is it habit forming?

    No habit forming tendencies were reported.
  • Are there any breast-feeding warnings?

    This medicine is known to excreted through the breast milk. It is not recommended for breastfeeding women unless absolutely necessary. However, monitoring of side effects like drowsiness, weight gain is necessary.
  • Is It safe with alcohol?

    It is unsafe to consume alcohol with this medicine.
  • Is it safe to drive while on this medicine?

    This medicine cause the side effects that affects the alertness of the patients. Thus driving must be avoided while taking it.
  • Does this affect kidney function?

    Caution must be taken in patients with severe kidney disease. Adjustment of dose is needed. Kindly consult your doctor before taking it,
  • Does this affect liver function?

    This medicine is probably found to be unsafe to be used in patients with liver disease and thus must be avoided. Kindly consult your doctor.
  • Missed Dose instructions

    Take the missed dose as soon as you remember. However, if it is almost time for the next scheduled dose then the missed dose should be skipped.
  • Overdose instructions

    Seek emergency medical treatment or contact the doctor in case of an overdose.
  • India

  • United States

  • Japan

Below is the list of medicines, which contains Duloxetine as ingredient

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Duloxetine is a serotonin-norepinephrine reuptake inhibitor. It works by inhibiting the reuptake of serotonin and norepinephrine thus increasing its levels in the brain and helps in relieving the symptoms of depression. It weakly inhibits the reuptake of dopamine.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

  • Interaction with Alcohol

    Duloxetine may increase the risk of liver injury if taken with alcohol. Avoid consumption of alcohol. Monitoring of liver enzymes is necessary. Any symptoms of abdominal pain, yellow discolouration of skin and eyes should be reported to the doctor.
  • Interaction with Lab Test

    Information not available.
  • Interaction with Medicine


    Duloxetine is not recommended with ciprofloxacin due to the risk of serious effects like the fast heartbeat, confusion, blurred vision. Inform the doctor if you are receiving these medications. An alternate medicine should be considered based on the clinical condition.


    Duloxetine may increase the risk of bleeding when taken with other medicines that affect the blood clotting. Any symptoms of blood in stools, nausea, dizziness should be reported to the doctor. Suitable dose adjustments or an alternate medicine should be considered based on the clinical condition.


    Duloxetine may increase the risk of low blood sodium levels when taken with diuretics. Any symptoms of nausea, dizziness, weakness should be reported to the doctor. Suitable dose adjustments or an alternate medicine should be considered based on the clinical condition.


    Duloxetine is not recommended with dextromethorphan due to the risk of the fast heartbeat, muscle spasm, tremors. Inform the doctor if you are receiving any cough preparation containing this medicine. An alternate medicine should be considered based on the clinical condition.
  • Interaction with Disease


    Duloxetine should be used with caution in the patients with diabetes mellitus due to the alteration in the blood glucose levels. Monitoring of blood glucose levels is necessary. Any signs and symptoms like increased blood glucose levels, increased urination should be reported to the doctor.


    Duloxetine should be used with caution in the patients with glaucoma due to the increase in the fluid pressure in the eye. Inform the doctor if you have any history of eye disorder. Suitable dose adjustments or an alternate medicine should be considered based on the clinical condition.
  • Interaction with Food

    Information not available.
Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

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Table of Content
About Duloxetine
What are the uses of Duloxetine
What are the contraindications of Duloxetine ?
What are the side effects of Duloxetine ?
Key highlights of Duloxetine
What are the dosage instructions?
Where is the Duloxetine approved?
Medicines containing Duloxetine
How does this medication work?
What are the interactions of Duloxetine ?