EBV DNA, PCR Tips

HIV Infection and AIDS Treatment

Dr. Vinod Raina 91% (6502 ratings)
MD - General Medicine
Sexologist, Delhi
HIV Infection and AIDS Treatment

If an HIV infection, treatment is primarily aimed at preventing evolve as long as possible and do not give way to the disease AIDS . In this case, the treatment is against HIV itself. If the emergence of AIDS and its accompanying diseases occur as a lung inflammation or bowel, treatment should include them. It is important to maintain a healthy lifestyle so that the immune system does not see further harmed. Many infected with HIV also have counseling and self-help centers with other affected. Drug Treatments Currently it has good information about certain steps in the single expansion of HIV infection. Thus, it has been possible to develop drugs that inhibit certain evolutions of cell infestation. HIV treatment is also called highly active antiretroviral therapy and its abbreviation is HAART. Specifically, this treatment includes the following medications: The entry inhibitors , which inhibit the entry of 'HIV virus' in human cells. VHI prevent adhesion of immune cells and / or dissolution of the viral envelope with the cell membrane (fusion). The excipient enfuvirtide eg prevents fusion. The reverse transcriptase inhibitor blocks a special top virus that can translate the genetic information of the virus (DNA) reverse transcriptase. This group of drugs includes, for example, substances such as lamivudine , the tenofovir or nevirapine . Another top virus, integrase, incorporating HIV DNA genetic information translated into immune cells. In this case, inhibitors of this enzyme, apply called integrase inhibitors . The drug raltegravir contains these integrase inhibitors. The protease inhibitors destroy other HIV enzyme, the HIV protease. If a cell is infected with HIV, forms a component of protein which could be born new HIV viruses. Protease HIV plays an important role in the composition of this protein. Inhibitors of this enzyme are involved in virus appear less capable of action in affected cells. Examples of protease inhibitors are drugs fosamprenavir , indinavir , nelfinavir, and ritonavir . Although 'AIDS' remains an incurable disease, it may be well with a combination therapy . This combination consists of at least three different drugs; usually several inhibitors of reverse transcriptase which are combined with a protease inhibitor.

 

1 person found this helpful

IVF Tests Suggested To Check Infertility In Men!

 Indira Ivf 86% (64 ratings)
MBBS Bachelor of Medicine and Bachelor of Surgery
IVF Specialist, Udaipur
IVF Tests Suggested To Check Infertility In Men!

It is as important for the man as it is for the woman to undergo certain tests before the IVF cycle is started. Fertility is not only an issue for a woman, but it also might be for the man in question. There are certain tests that need to be conducted on men before they can gear up for IVF:

1. Semen Analysis: One of the most important tests for male infertility is semen analysis. Sometimes, a man may be completely healthy, but his sperm production could be of poor quality. Semen analysis is done to provide an accurate evaluation of sperm number, the ability to move (motility), size and shape (morphology), as well as the consistency and volume of the sample collected.

2. Binding Test: Sometimes agglutination occurs where the sperms might stick to each other by their heads or tails. Sperm antibodies might cause this problem. The IVF treatment's success might be compromised if this happens. A simple binding test is done to determine this.

3. Trial Wash: This is also known as sperm wash. It is mostly done to remove chemicals from the sperm. Not doing a sperm wash might end up affecting the later stages of the IVF treatment. In this process, the misshapen and immotile sperm is separated so a clean sample of motile and healthy sperm can be collected.

4. TUNEL Assay: Since sperms build up about half of a child's genetic makeup, a TUNEL Assay or 'sperm DNA test' is required. This test is done to measure the sperm population that have fragmented DNA. Negative impacts on genetics can hamper the success of the fertility treatment.

TUNEL Assay is usually recommended to men with:

  • Leukocytes detected by the sperm analysis
  • Age approaching 50
  • A history of diabetes II type or prostatitis
  • Exposure to chemicals or prolonged heat at workplaces

5. Screening for Infectious Diseases: This test is done for both the partners to check for diseases like AIDS, Hepatitis C, and so on. In case you have a concern or query you can always consult an expert & get answers to your questions!

3868 people found this helpful

Tests Suggested For Men Before IVF!

Dr. Sandeep Talwar 89% (31 ratings)
MBBS, DNB - Obstetrics and Gynecology, Fellowship In Reproductive Medicine
IVF Specialist, Delhi
Tests Suggested For Men Before IVF!

It is as important for the man as it is for the woman to undergo certain tests before the IVF cycle is started. Fertility is not only an issue for a woman, but it also might be for the man in question.

There are certain tests that need to be conducted on men before they can gear up for IVF:

1. Semen Analysis: One of the most important tests for male infertility is semen analysis. Sometimes, a man may be completely healthy, but his sperm production could be of poor quality. Semen analysis is done to provide an accurate evaluation of sperm number, the ability to move (motility), size and shape (morphology), as well as the consistency and volume of the sample collected.

2. Binding Test: Sometimes agglutination occurs where the sperms might stick to each other by their heads or tails. Sperm antibodies might cause this problem. The IVF treatment's success might be compromised if this happens. A simple binding test is done to determine this.

3. Trial Wash: This is also known as sperm wash. It is mostly done to remove chemicals from the sperm. Not doing a sperm wash might end up affecting the later stages of the IVF treatment. In this process, the misshapen and immotile sperm is separated so a clean sample of motile and healthy sperm can be collected.

4. TUNEL Assay: Since sperms build up about half of a child's genetic makeup, a TUNEL Assay or 'sperm DNA test' is required. This test is done to measure the sperm population that have fragmented DNA. Negative impacts on genetics can hamper the success of the fertility treatment.

TUNEL Assay is usually recommended to men with:

  • Leukocytes detected by the sperm analysis
  • Age approaching 50
  • A history of diabetes II type or prostatitis
  • Exposure to chemicals or prolonged heat at workplaces

5. Screening for Infectious Diseases: This test is done for both the partners to check for diseases like AIDS, Hepatitis C, and so on.

2897 people found this helpful

Eligibility Criteria For Men Prior IVF!

Dr. Nalini Gupta 88% (264 ratings)
M.Sc, MD, MBBS
IVF Specialist, Delhi
Eligibility Criteria For Men Prior IVF!

It is as important for the man as it is for the woman to undergo certain tests before the IVF cycle is started. Fertility is not only an issue for a woman, but it also might be for the man in question. There are certain tests that need to be conducted on men before they can gear up for IVF:

1. Semen Analysis: One of the most important tests for male infertility is semen analysis. Sometimes, a man may be completely healthy, but his sperm production could be of poor quality. Semen analysis is done to provide an accurate evaluation of sperm number, the ability to move (motility), size and shape (morphology), as well as the consistency and volume of the sample collected.

2. Binding Test: Sometimes agglutination occurs where the sperms might stick to each other by their heads or tails. Sperm antibodies might cause this problem. The IVF treatment's success might be compromised if this happens. A simple binding test is done to determine this.

3. Trial Wash: This is also known as sperm wash. It is mostly done to remove chemicals from the sperm. Not doing a sperm wash might end up affecting the later stages of the IVF treatment. In this process, the misshapen and immotile sperm is separated so a clean sample of motile and healthy sperm can be collected.

4. TUNEL Assay: Since sperms build up about half of a child's genetic makeup, a TUNEL Assay or 'sperm DNA test' is required. This test is done to measure the sperm population that have fragmented DNA. Negative impacts on genetics can hamper the success of the fertility treatment.

TUNEL Assay is usually recommended to men with:

  • Leukocytes detected by the sperm analysis
  • Age approaching 50
  • A history of diabetes II type or prostatitis
  • Exposure to chemicals or prolonged heat at workplaces

5. Screening for Infectious Diseases: This test is done for both the partners to check for diseases like AIDS, Hepatitis C, and so on.

3437 people found this helpful

4 Causes Of Melanoma!

MBBS, MD - Dermatology
Dermatologist, Ghaziabad
4 Causes Of Melanoma!

Melanoma, also referred to as malignant melanoma, is a type of cancer. It evolves from the color or pigment containing cells known as melanocytes. Melanomas normally happen in the skin, yet may once in a while it may happen in the mouth, guts, or eyes as well. In women, it generally happens in the legs, while in men they are most regularly on the back. Sometime a mole may also raise your concern by increasing in size, developing abnormal edges, a change of color or itching and irritability. This may also prompt breakdown of the skin.

Some general facts on melanoma are mentioned below:
1. More than one million new instances of skin cancer or melanoma are analyzed every year.

2. There has been a 2000% increase in rate of melanoma since the year 1930. One out of fifty get affected by this cancer.

3. This is common in young women and causes many deaths.

4. Women below the age of forty are at more risk of getting melanoma than any other kind of cancer such as breast cancer.

5. There has been a high rise in the rate of melanoma from 1970 to 2008. There has been an 800% increase in young women and 400% increase in case of similar aged men.

6. Early recognition makes melanoma treatable. It is screened for growth very minimally.

Primary causes:
Melanomia may be caused primarily due to these causes:

  1. The most primary cause of melanoma is ultraviolet light (UV) in people with a low level of skin pigment. The UV light might be from either the sun or from different sources, for example, tanning devices. Around 25% of cases occur from or in the form of moles
  2. Those with numerous moles, presence of the disease in family members and who have poor immunity are at more noteworthy risk to get melanoma. Various uncommon hereditary defects, such as xeroderma pigmentosum increase the risk of melanoma.
  3. The individuals who work on airplanes seem to have an expanded danger, due to more contact with UV rays.
  4. Ultraviolet UVB light of wavelengths between 315 - 280 nm from the sun react with the skin cell DNA and result in a kind of direct DNA harm called cyclobutane pyrimidine dimers (CPDs). 

In order to stay away or avoid melanoma, you should:

  1. Spend less time in direct sunlight and should seek shade.
  2. Avoid the sun at peak hours.
  3. Examine your skin at times for some kind of change.
  4. Keep away from tanning salons.

Melanoma is a dangerous form of cancer and causes a lot of deaths. You should stay away from anything that causes melanoma.

3864 people found this helpful

Fifth Disease "Slapped Cheek Syndrome" And Homeopathy

Dr. Jagandeep Kaur 91% (1329 ratings)
BHMS
Homeopathy Doctor, Ludhiana
Fifth Disease "Slapped Cheek Syndrome" And Homeopathy

Fifth disease also known as slapped cheek syndrome is a mild and common illness in children that is caused by a virus called human parvovirus b19.
The medical name for fifth disease is" erythema infectiosum (ei).

Symptoms and signs include a rash as if the face has been slapped. In north america, the disease has been referred to as slapped cheek syndrome or as" slapcheek. Parvovirus infection is a common and highly contagious childhood ailment. It was one of five common childhood illnesses characterized by a rash and therefore named" fifth disease.
The name fifth disease comes from a classification system developed in the 1890's but it is no longer used. It was the fifth in a list of the five most common rashes of childhood and acquired this name.

This infection occurs primarily in school-aged children between 5 and 14 years of age during winter and spring. In most children, parvovirus infection is mild and requires little treatment.

The virus is thought to spread via droplets in the air as respiratory secretions transmitted by coughs and sneezesor by blood from other infected people. Early during the illness, nasal secretions contain the viral dna. Blood has been found to contain viral particles as well as dna.

Cases of fifth disease can occur either sporadically or as part of community outbreaks.

Outbreaks occur mainly in elementary schools during the spring.

Half of the cases occur from spread of the virus to others in the patient's household. Transmission of the infection in schools is less common.


About 10% or fewer of young children are immune.

People with this illness are contagious before the onset of symptoms and are probably not contagious after they develop the rash.

The incubation period (the time from acquiring the infection to the development of symptoms) usually lasts between 4 and 21 days.

Homeopathic remedies for fifth disease - slapped cheek syndrome

Apis, belladona, chamomilla, calendula, sulphur, urtica urens etc.

To find out the right medicine consult a homeopath.

Three Person IVF - Certain Questions That Need Answers!

MBBS Bachelor of Medicine and Bachelor of Surgery, MD - Obstetrtics & Gynaecology
IVF Specialist, Nashik
Three Person IVF - Certain Questions That Need Answers!

Diseases which are caused by some sort of genetic mutations in the mitochondria, can be quite deadly. This is the reason why Mitochondrial Replacement Therapy, also known as Three-Person IVF is being seen as a much more desired option for those women, who carry mitochondrial mutations.

Almost all the genes in a cell remain trapped in the nucleus but a small fraction of them remain present in the mitochondria as well. During the fertilisation of eggs, the genes in the egg’s nucleus get combined with the genes in the nucleus of the sperm, which in turn creates a new cell. On the other hand, mitochondrial genes are involved in this mixing. Rather they are passed on from mother to child.

The main reason behind three-person IVF is to help find a way, so that the mitochondrial genes can be replaced in an affected cell of the egg prior to the time they get passed on to the child. This is carried out when the egg cell of the donor gets acquired and the nucleus is removed from the cell, hence leaving the cell with healthy mitochondria. After that, the mother’s nucleus, which stays unaffected, is removed and gets placed in the donor’s egg cell, thereby creating an egg cell which must contain healthy genes not only in the nucleus but also in the mitochondria.

Genes Are Complex in Nature

  • Genes communicate with one another. Cells get engaged in a variety of complex processes like division of cells or respiration, which are highly unlikely to be performed only by single genes acting in an isolated manner. So a network of genes works together, with each one making a contribution of certain particular components.
  • Genes tend to be variable in nature, which basically means that no two genomes are similar. Due to this reason, the result of a typical pair of genes interacting with one another will at times be different for different individuals. This is the dark side of genetics, which has not been studied in a comprehensive manner and experts are not aware of exactly how widespread this might be.
  • Experts call this type of effect as Epistasis, which can occur between individual genes, between two or more sets of genes or even between whole genomes. The one occurring between whole genomes, has relevance to discuss about the safety and ethics of MRT. The reason is that, when a mitochondrial genome from a donor replaces the affected mitochondria, the parents’ nuclear DNA must communicate with a completely new genomic partner. The ethical implications related to the epistasis getting changed between nuclear DNA and mitochondrial have thus far been completely ignored.

Ethics Comes First
The review of the ethics related to MRT or Three-Person IVF came up with the conclusion that if the procedure was safe, then it could be considered as ethical. In other words, they concluded that if the trials carried out on humans showed that the treatment undertaken was safe, then it could also be considered as ethical as well.

3522 people found this helpful

Tests Suggested For Men Before IVF

MBBS, MD - Obstetrtics & Gynaecology
IVF Specialist, Nashik
Tests Suggested For Men Before IVF

It is as important for the man as it is for the woman to undergo certain tests before the IVF cycle is started. Fertility is not only an issue for a woman, but it also might be for the man in question. There are certain tests that need to be conducted on men before they can gear up for IVF:

1. Semen Analysis: One of the most important tests for male infertility is semen analysis. Sometimes, a man may be completely healthy, but his sperm production could be of poor quality. Semen analysis is done to provide an accurate evaluation of sperm number, the ability to move (motility), size and shape (morphology), as well as the consistency and volume of the sample collected.

2. Binding Test: Sometimes agglutination occurs where the sperms might stick to each other by their heads or tails. Sperm antibodies might cause this problem. The IVF treatment's success might be compromised if this happens. A simple binding test is done to determine this.

3. Trial Wash: This is also known as sperm wash. It is mostly done to remove chemicals from the sperm. Not doing a sperm wash might end up affecting the later stages of the IVF treatment. In this process, the misshapen and immotile sperm is separated so a clean sample of motile and healthy sperm can be collected.

4. TUNEL Assay: Since sperms build up about half of a child's genetic makeup, a TUNEL Assay or 'sperm DNA test' is required. This test is done to measure the sperm population that have fragmented DNA. Negative impacts on genetics can hamper the success of the fertility treatment.

TUNEL Assay is usually recommended to men with:

  • Leukocytes detected by the sperm analysis
  • Age approaching 50
  • A history of diabetes II type or prostatitis
  • Exposure to chemicals or prolonged heat at workplaces

5. Screening for Infectious Diseases: This test is done for both the partners to check for diseases like AIDS, Hepatitis C, and so on.

2895 people found this helpful

Prior Checks For Men In IVF!

Dr. Dipen Prajapati 88% (150 ratings)
MBBS, Post Doctoral Fellowship in Reproductive Medicine
IVF Specialist, Surat
Prior Checks  For Men In IVF!

It is as important for the man as it is for the woman to undergo certain tests before the IVF cycle is started. Fertility is not only an issue for a woman, but it also might be for the man in question. There are certain tests that need to be conducted on men before they can gear up for IVF:

1. Semen Analysis: One of the most important tests for male infertility is semen analysis. Sometimes, a man may be completely healthy, but his sperm production could be of poor quality. Semen analysis is done to provide an accurate evaluation of sperm number, the ability to move (motility), size and shape (morphology), as well as the consistency and volume of the sample collected.

2. Binding Test: Sometimes agglutination occurs where the sperms might stick to each other by their heads or tails. Sperm antibodies might cause this problem. The IVF treatment's success might be compromised if this happens. A simple binding test is done to determine this.

3. Trial Wash: This is also known as sperm wash. It is mostly done to remove chemicals from the sperm. Not doing a sperm wash might end up affecting the later stages of the IVF treatment. In this process, the misshapen and immotile sperm is separated so a clean sample of motile and healthy sperm can be collected.

4. TUNEL Assay: Since sperms build up about half of a child's genetic makeup, a TUNEL Assay or 'sperm DNA test' is required. This test is done to measure the sperm population that have fragmented DNA. Negative impacts on genetics can hamper the success of the fertility treatment.

TUNEL Assay is usually recommended to men with:

  • Leukocytes detected by the sperm analysis
  • Age approaching 50
  • A history of diabetes II type or prostatitis
  • Exposure to chemicals or prolonged heat at workplaces

5. Screening for Infectious Diseases: This test is done for both the partners to check for diseases like AIDS, Hepatitis C, and so on.

2864 people found this helpful

Melanoma - How To Avert It?

MBBS, FCPS - Dermatology, Venereology & Leprosy, DVD, DDV
Dermatologist, Mumbai
Melanoma - How To Avert It?

Melanoma is a condition which mainly indicates a severe malfunction of the melanocytes or the melanin-producing cells of the body. These cells are responsible for giving you your skin colour, tone and complexion. Usually, a person suffering from melanoma will have many normal and irregular moles as well as melanoma in the eye and digestive tracts too.

Some general facts on melanoma are mentioned below:

  1. Melanoma is common in young women and causes many deaths.

  2. More than one million new instances of skin cancer or melanoma are analyzed every year.

  3. There has been a 2000% increase in the rate of melanoma since the year 1930. One out of fifty get affected by this cancer.

  4. There has been a high rise in the rate of melanoma from 1970 to 2008. There has been an 800% increase in young women and 400% increase in case of similar-aged men.

  5. Early recognition makes melanoma treatable. It is screened for growth very minimally.

Primary causes Melanoma may be caused primarily due to these causes:

The most primary cause of melanoma is ultraviolet light (UV) in people with a low level of skin pigment. The UV light might be from either the sun or from different sources, for example, tanning devices. Around 25% of cases occur from or in the form of moles.

The individuals who work on airplanes seem to have an expanded danger, due to more contact with UV rays.

Ultraviolet UV light of wavelengths between 315 - 280 nm from the sun react with the skin cell DNA and result in a kind of direct DNA harm called cyclobutane pyrimidine dimers (CPDs).

In order to stay away or avoid melanoma, you should:

  1. Avoid the sun at peak hours.

  2. Examine your skin at times for some kind of change.

  3. Keep away from tanning salons.Melanoma is a dangerous form of cancer and causes a lot of deaths. You should stay away from anything that causes melanoma.

3948 people found this helpful