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Tenofovir

Prescription vs.OTC: Prescription by Doctor required

Tenofovir falls under a class of antiviral drugs known as reverse transcriptase inhibitor. It is used in combination with other medications to treat HIV infection. It is also used to treat long-term HBV infection. It treats HIV infection by blocking the growth of the virus and its ability to infect the other liver cells.

On using Tenofovir you may experience side effects such as gas, headache, reduced appetite, back pain, vomiting, fatigue, weight loss, fever, depression, chest pain, swelling, nausea and stomach pain. If the allergic reactions persist or become severe over time seek medical attention right away.

Before using this medication tell your doctor if: you are allergic to any ingredient contained within Tenofovir, you have other allergies, you have kidney/ liver/ disorders, you have both HIV and HBV infections, you have difficulty swallowing your tablets, you are already taking other medications, you are pregnant, or are planning to become pregnant or are breastfeeding a baby.

The dosage for this medication is determined by the doctor based on your age, medical history and current condition. The usual dose in adults for HIV infection is about 300 mg, to be taken orally once daily.

Information given here is based on the salt and content of the medicine. Effect and uses of medicine may vary from person to person. It is advicable to consult a HIV Specialist before using this medicine.

hiv infection

chronic hepatitis b virus (hbv) infection

In addition to its intended effect, Tenofovir may cause some unwanted effects too. In such cases, you must seek medical attention immediately. This is not an exhaustive list of side effects. Please inform your doctor if you experience any adverse reaction to the medication.

Is It safe with alcohol?

Interaction with alcohol is unknown. Please consult your doctor.

Are there any pregnancy warnings?

Tenfoclear 300mg tablet is probably safe to use during pregnancy.
Animal studies have shown low or no adverse effect on the foetus, however, there are limited human studies. Please consult your doctor.

Are there any breast-feeding warnings?

Tenfoclear 300mg tablet is probably unsafe to use during breastfeeding. Please consult your doctor.

Is it safe to drive while on this medicine?

Dizziness has been reported in some of the patients.

Does this affect kidney function?

Caution should be used in patients with impaired renal function.

Does this affect liver function?

There is no data available. Please consult doctor before consuming the drug.

Are there any missed dose instructions?

If you miss a dose of Tenofovir, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Below is the list of medicines, which contains Tenofovir as ingredient
Mylan Pharmaceuticals Pvt Ltd
Veritaz Healthcare Ltd
Mankind Pharma Ltd
Cipla Ltd
Natco Pharma Ltd
Cipla Ltd
Hetero Drugs Ltd
Mylan Pharmaceuticals Pvt Ltd
Sun Pharmaceutical Industries Ltd
Emcure Pharmaceuticals Ltd
Cipla Ltd
Hetero Drugs Ltd
Emcure Pharmaceuticals Ltd
Emcure Pharmaceuticals Ltd
Emcure Pharmaceuticals Ltd
MSD Pharmaceuticals Pvt Ltd
Abbott India Ltd
Abbott India Ltd
Emcure Pharmaceuticals Ltd
Tenofovir causes inhibition of activity of the HIV reverse transcriptase. This activity occurs by way of competition to deoxyadenosine 5’triphosphate, natural substrate after getting incorporated within the DNA by termination of the chain.
Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

Interaction with Medicine

Valgaids 450Mg Tablet

What are you using Tenofovir for?
chronic hepatitis b virus (hbv) infection
Other
hiv infection
How much was the improvement?
Poor
Excellent
Average
How long did it take before seeing improvement?
More than 2 days
Within 2 days
Within a day
Within 2 hours
How frequently did you take this medicine?
Once a day
Not taking on daily level
How did you take this medicine?
With Food
With or without food
Empty stomach
What were the side effects of this medicine?
Muscle pain
Pain
Nausea
Weakness
Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

Popular Questions & Answers

Sir I sex with my neighbour without condom. Her husband also sex with him. She has also 2 children. Shall I get aids or HIV? Please answer.

MBBS
Internal Medicine Specialist, Kendujhar
Hello, Thanks for your query on Lybrate "As" per your clinical history is concerned HIV can spread from sexual contact or via infected blood so first check if she is not a HIV patient. To prevent it in future follow like this - 1) Try to use a new condom every time you have sex. If you don't know the HIV status of your partner, use a new condom every time you have anal or vaginal sex. Women can use a female condom. Use only water-based lubricants. Oil-based lubricants can weaken condoms and cause them to break. During oral sex use a condom, dental dam a piece of medical-grade latex or plastic wrap. 2) Talk with your treating Doctor about use of the drug Truvada and it contains emtricitabine-tenofovir to reduce the risk of sexually transmitted HIV infection in those who are at high risk. 3) Use a clean needle. If you use a needle to inject drugs, make sure it's sterile and don't share it. 4) Consider male circumcision. And it can help reduce a man's risk of acquiring HIV. Hope that helps.

Hi please need your urgent assistance on what to be done, I recently had protected intercourse but Condom was not correctly put with a HIV positive person, which I got to know only on the next day, I started PEP by using Duovir within 30 hours and have completed 2 doses, I have not done any test yet as they said it would not be conclusive and to wait at least for 4 weeks, please advise on PEP treatment with Duovir and it's side effects and effectiveness and also optimum time to take it since not many doctors in my city are aware of this, I'm very scared since this was also my first time was never sexually active before this, please advise.

MBBS, DGO, PhD - HIV Medicine
HIV Specialist, Chandigarh
Hi please need your urgent assistance on what to be done, I recently had protected intercourse but Condom was not cor...
Hi! Welcome to Lybrate! PEP is effective, if started as early as possible, within 72 hours of the exposure and if continued regularly for 28 days. There could be minimal nausea or vomiting sensation when initiated with the combination which you have initiated. Before initiation, it is suggested to know your Baseline status of HIV and also for HBV and HCV. The PEP drugs for HIV are recommended to start only if Baseline status of HIV is Negative After completion of PEP, tests are recommended again at six weeks and if Negative, a confirmatory test at three months of last exposure. Please revert for any further information. Best wishes!
1 person found this helpful

Hi, My husband has HBeAg negative and Anti HBe positive. And his CBC test is fine SGOT -- 63 SGPT -- 118 HIV I& II (TRI-DOT) --NEGATIVE Viral Load -- 5634 IU/ml Log10 Value -- 3.75 Doctor suggested to take Tenofovir Disoproxil Fumarate 300 MG tablet. Is there any medicine other than this? Or this is the right one?

BASM, MD, MS (Counseling & Psychotherapy), MSc - Psychology, Certificate in Clinical psychology of children and Young People, Certificate in Psychological First Aid, Certificate in Positive Psychology, Positive Psychiatry and Mental Health
Psychologist, Palakkad
Hi, My husband has HBeAg negative and Anti HBe positive. And his CBC test is fine
SGOT -- 63
SGPT -- 118
HIV I& II (T...
Dear, HIV spreads through Contact between broken skin, wounds, or mucous membranes and HIV-infected blood or blood-contaminated body fluids. Deep, open-mouth kissing if both partners have sores or bleeding gums and blood from the HIV-positive partner gets into the bloodstream of the HIV-negative partner. HIV is not spread through saliva. Take care.
2 people found this helpful

I am hiv+ from last 6 years never took art as my cd4 is high but I am only 45 kg plzz refer me any protein supplement, as far as any disease is concern I am not suffering from any disease now.

MBBS, PG Diploma (HIV Medicines)
HIV Specialist, Surat
I am hiv+ from last 6 years never took art as my cd4 is high but I am only 45 kg plzz refer me any protein supplement...
This early-release guideline makes available two key recommendations that were developed during the revision process in 2015. First, antiretroviral therapy (ART) should be initiated in everyone living with HIV at any CD4 cell count. Second, the use of daily oral pre-exposure prophylaxis (PrEP) is recommended as a prevention choice for people at substantial risk of HIV infection as part of combination prevention approaches. The first of these recommendations is based on evidence from clinical trials and observational studies released since 2013 showing that earlier use of ART results in better clinical outcomes for people living with HIV compared with delayed treatment. The second recommendation is based on clinical trial results confirming the efficacy of the ARV drug tenofovir for use as PrEP to prevent people from acquiring HIV in a wide variety of settings and populations. The recommendations in this guideline will form part of the revised consolidated guidelines on the use of ARV drugs for treating and preventing HIV infection to be published by WHO in 2016.
2 people found this helpful

Popular Health Tips

How Can Hepatitis B and C Be Treated Through Internal Medicine?

MD - Internal Medicine, MBBS
Internal Medicine Specialist, Mumbai
How Can Hepatitis B and C Be Treated Through Internal Medicine?

Hepatitis B and C are considered the world’s chronic viral hepatitis which kills a huge number of people every year. Even though it accounts for massive suffering as well as early death, it could only attract relatively less national and international attention. While the deaths caused by tuberculosis, malaria and HIV/AIDS have reduced to a great extent since the early 2000s, deaths stemming from hepatitis B and C are rising at a fast pace. It kills around 1 million people across the world.

Can medicine help in the treatment of hepatitis B and C?
There are numerous FDA approved medications available for the treatment of Hepatitis B and C. Here are some of the best medicines for this, but before you take them, you must consult an expert who can evaluate your symptoms and recommend the right drugs for you.

Medicines for Hepatitis B:

  1. Entecavir: It is used in chronic hepatitis B virus infection and can treat active viral replication.
  2. Lamivudine: It is used for treating chronic hepatitis B which is associated with Hepatitis B viral replication along with active liver inflammation.
  3. Adefovir dipivoxil: This is used for the treatment of the disease in children below the age 12 years.
  4. Interferon alpha 2B: It can be used for young children aged 1 year who are affected by the disease along with compensated liver disease.
  5. Pegylated interferon: It is used for the treatment of adult patients with HBeAg positive and negative chronic hepatitis. If the patient has compensated liver disease along with liver inflammation and evidence of viral replication, then this medicine is usually given.
  6. Telbivudine: When there is chronic hepatitis with adult patients along with persistent elevations in ALT and AST or previously active disease, this medicine may have to be administered.
  7. Tenofovir alafenamide: It is indicated for the treatment of chronic hepatitis B virus infection in adults with compensated liver disease.

Medicines for Hepatitis C:

  1. Ribavirin: This medicine can be used in combination with other medicines for chronic hepatitis C virus infection. Ribavirin can be utilized for compensated liver disease in patients who have not been treated with interferon alpha.
  2. Daclatasvir: This is an NS5A replication complex inhibitor which is often given with sofosbuvir for the treatment of patients with chronic HCV genotype 3 infection.
  3. Sofosbuvir and Velpatasvir: The combination of these two medicines is used for the treatment of adult patients with chronic genotype 1 to 6 without any infection. It may be used in combination with ribavirin in patients with compensated or decompensated cirrhosis.
  4. Ledipasvir: A fixed-dose of a combination of hepatitis C virus inhibitor and Ledipasvir can be employed in the treatment of hepatitis genotype 1 infection in adults.

Both in the cases of Hepatitis B and C, it is important to diagnose the infection early. Prevention and cure are possible with precautionary measures and prescribed medications.

In case you have a concern or query you can always consult an expert & get answers to your questions!

5882 people found this helpful

Hiv Treatment

MD - General Medicine
Sexologist, Delhi
Hiv Treatment

HIV treatment is done by antiviral drugs, there are number of antiviral drugs available in the market, usually HIV is treated with combination of drugs, usually two to three drugs are used in treating HIV in initial stage, we can change the combination of drugs according to requirement of the patient. Drugs can be adjusted or increased if there is resistance of HIV in the patient.

There are number of compounds (about 22 in number) which have been formally approved (by the US Food and Drug Administration) for the treatment of HIV infections (AIDS). According to their point of intervention with the HIV replicative cycle, these compounds can be classified in 5 categories: (1) NRTIs (nucleoside reverse transcriptase inhibitors): azidothymidine, didanosine, zalcitabine, stavudine, lamivudine, abacavir and emtricitabine; (2) NtRTIs (nucleotide reverse transcriptase inhibitors): tenofovir, administered as its oral prodrug form TDF (tenofovir disoproxil fumarate); (3) NNRTIs (non-nucleoside reverse transcriptase inhibitors): nevirapine, delavirdine and efavirenz; (4) PIs (HIV protease inhibitors): saquinavir, ritonavir, indinavir, nelfinavir, amprenavir, lopinavir, atazanavir, fosamprenavir, tipranavir and darunavir; and (5) FIs (fusion inhibitors): enfuvirtide. Starting from the drugs which are currently available for the treatment of AIDS, numerous combinations could be envisaged. Drug combinations are, in principle, aimed at obtaining synergism between the compounds (reasonably expected if they act by different mechanisms), while reducing the likelihood for drug resistance development. Such anti-HIV drug combination regimens were initiated about 10 years ago and have been generally referred to as HAART (for highly active antiretroviral therapy). While HAART originally consisted of a pill burden of twenty (or more) pills per day, this has been gradually diminished over the past few years, and, since July 2006, a all-in-one pill (teevir from myelin and virotrenz from Ranbaxy sun pharma) has become available, which contains three anti-HIV drugs (tenofovir disoproxil fumarate 300 mg, emtricitabine200mg and efavirenz 600 mg) to be taken as a single pill only once daily. Given the information that has been acquired on the therapeutic use (efficacy, safety) of tenofovir disoproxil fumarate over the past five years, it would now seem mandatory to further consider the prophylactic use of TDF [and its combination with emtricitabine (Truvada) and/or Atripla], as a single daily pill to prevent HIV infection. New combinations of drugs are also available which include tenofovir 300 mg lamivudine 150 mg which are very new drugs.


Now a days we can treat patients who had sex with some sex worker or any male transgender or some unknown person and during sexual intercourse condom gets bursted , we can treat them if they come to us within 72 hours of direct contact, these medicines are called POST-EXPOSURE PROPHYLAXIS (PEP) drugs for HIV or prophylactic treatment for HIV, by using these drugs we can treat a patient and we can stop transfusion of HIV virus to the person.

PEP involves taking anti HIV drugs as soon as possible after having been exposed to unprotected sex with some sex worker or transgender or with homosexual PrEP is a new HIV prevention method in which people who do not have HIV infection take pills of medicine daily to reduce the risk of becoming infected with HIV virus ,PEP should be taken within 72 hours of exposure to unprotected sex before the virus has time to rapidly duplicate in your body, PEP consists of 2-3 antiretroviral drugs taken for 28 days.

10 people found this helpful

HIV Infection and AIDS Treatment

MD - General Medicine
Sexologist, Delhi
HIV Infection and AIDS Treatment

If an HIV infection, treatment is primarily aimed at preventing evolve as long as possible and do not give way to the disease AIDS . In this case, the treatment is against HIV itself. If the emergence of AIDS and its accompanying diseases occur as a lung inflammation or bowel, treatment should include them. It is important to maintain a healthy lifestyle so that the immune system does not see further harmed. Many infected with HIV also have counseling and self-help centers with other affected. Drug Treatments Currently it has good information about certain steps in the single expansion of HIV infection. Thus, it has been possible to develop drugs that inhibit certain evolutions of cell infestation. HIV treatment is also called highly active antiretroviral therapy and its abbreviation is HAART. Specifically, this treatment includes the following medications: The entry inhibitors , which inhibit the entry of 'HIV virus' in human cells. VHI prevent adhesion of immune cells and / or dissolution of the viral envelope with the cell membrane (fusion). The excipient enfuvirtide eg prevents fusion. The reverse transcriptase inhibitor blocks a special top virus that can translate the genetic information of the virus (DNA) reverse transcriptase. This group of drugs includes, for example, substances such as lamivudine , the tenofovir or nevirapine . Another top virus, integrase, incorporating HIV DNA genetic information translated into immune cells. In this case, inhibitors of this enzyme, apply called integrase inhibitors . The drug raltegravir contains these integrase inhibitors. The protease inhibitors destroy other HIV enzyme, the HIV protease. If a cell is infected with HIV, forms a component of protein which could be born new HIV viruses. Protease HIV plays an important role in the composition of this protein. Inhibitors of this enzyme are involved in virus appear less capable of action in affected cells. Examples of protease inhibitors are drugs fosamprenavir , indinavir , nelfinavir, and ritonavir . Although 'AIDS' remains an incurable disease, it may be well with a combination therapy . This combination consists of at least three different drugs; usually several inhibitors of reverse transcriptase which are combined with a protease inhibitor.

 

1 person found this helpful

How is Hiv Treatment ?

MD - General Medicine
Sexologist, Delhi
How is Hiv  Treatment ?

Hiv treatment is done by antiviral drugs, there are a number of antiviral drugs available in the market, usually HIV is treated with a combination of drugs, usually two to three drugs are used in treating HIV in the initial stage, we can change the combination of drugs according to the requirement of the patient. Drugs can be adjusted or increased if there is the resistance of HIV in the patient.

There are a number of compounds (about 22 in number) which have been formally approved (by us food and drug administration) for the treatment of HIV infections (aids). According to their point of intervention with the HIV replicative cycle, these compounds can be classified into 5 categories: (1) nrtis (nucleoside reverse transcriptase inhibitors): azidothymidine, didanosine, zalcitabine, stavudine, lamivudine, abacavir and emtricitabine; (2) ntrtis (nucleotide reverse transcriptase inhibitors): tenofovir, administered as its oral prodrug form tdf (tenofovir disoproxil fumarate); (3) nnrtis (non-nucleoside reverse transcriptase inhibitors): nevirapine, delavirdine and efavirenz; (4) pis (hiv protease inhibitors): saquinavir, ritonavir, indinavir, nelfinavir, amprenavir, lopinavir, atazanavir, fosamprenavir, tipranavir and darunavir; and (5) fis (fusion inhibitors): enfuvirtide. Starting from the drugs which are currently available for the treatment of aids, numerous combinations could be envisaged. Drug combinations are, in principle, aimed at obtaining synergism between the compounds (reasonably expected if they act by different mechanisms), while reducing the likelihood of drug resistance development. Such anti-hiv drug combination regimes were initiated about 10 years ago and have been generally referred to as haart (for highly active antiretroviral therapy). While haart originally consisted of a pill burden of twenty (or more) pills per day, this has been gradually diminished over the past few years, and, since July 2006, an all-in-one pill (teevir from myelin and virotrenz from ranbaxy sun pharma) has become available, which contains three anti-hiv drugs (tenofovir disoproxil fumarate 300 mg, emtricitabine200mg and efavirenz 600 mg) to be taken as a single pill only once daily. Given the information that has been acquired for the therapeutic use (efficacy, safety) of tenofovir disoproxil fumarate over the past five years, it would now seem mandatory to further consider the prophylactic use of tdf [and its combination with emtricitabine (truvada) and/or atripla], as a single daily pill to prevent HIV infection. New combinations of drugs are also available which include tenofovir 300 mg lamivudine 150 mg which is very new drugs.


Now a days we can treat patients who had sex with some sex worker or any male transgender or some unknown person and during sexual intercourse condom gets bursted, we can treat them if they come to us within 72 hours of direct contact, these medicines are called post-exposure prophylaxis (pep) drugs for hiv or prophylactic treatment for hiv, by using these drugs we can treat a patient and we can stop transfusion of hiv virus to the person.

Pep involves taking anti hiv drugs as soon as possible after having been exposed to unprotected sex with some sex worker or transgender of with homosexual prep is a new hiv prevention method in which people who do not have hiv infection take pills of medicine daily to reduce the risk of becoming infected with hiv virus, pep should be taken within 72 hours of exposure to unprotected sex before the virus has time to rapidly duplicate in your body, pep consists of 2-3 antiretroviral drugs taken for 28 days.

3 people found this helpful
Table of Content
About Tenofovir
When is Tenofovir prescribed?
What are the side effects of Tenofovir ?
Key highlights of Tenofovir
What are the dosage instructions?
Medicines containing Tenofovir
How does medicine works?
What are the interactions for Tenofovir ?