I am suffering with chronic treatment resistant depression since last 10 years and also anxiety disorder. I have many kind of antidepressant like escitalopram, venlafaxine, duloxtine,mirtazapine, quetiapine,olanzapine, lithium and I have also take ect 5 sitting no response. But still I did not take zoloft and prozac. Currently I am taking fluvoxamine, risperidone but no relief. I am nothing understand what I can do now.

Dr. Prof. Jagadeesan M.S.Psychiatrist17yrs exp

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Despite all measure 5% have ressitant depression. You need to discuss with your psychiatrist what works best and pursue the same. Other things to try are cognitive behvaioral therapy, tms and ect. Good luck.  

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Mr. Saul PereiraPsychologist50yrs exp

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You seem to have a serious problem of depression that definitely needs the help of a counselor too. Relying merely on medication alone to sole your problem will not suffice. In the meantime, please do the following sincerely because you could resolve the problem better with good cooperation: have a good night?s sleep, have a good breakfast of more proteins, meditate often, remain free of stress, eat a lot of fiber, nuts, avocado, exercise regularly, eat dark chocolate, do yoga meditation exercises, spend time in nature or gardening, etc. I suggest you do the opposite of what this depression makes you feel like doing (actually, not doing): you will need to fight this condition. You must become active; stay upright during the daylight time; meet people; never sleep during the day, wake up by 6 am every day, play some active games, especially contact games, do physical exercises, talk to people and join some social clubs, attend yoga classes etc. Watch sitcoms on tv or comedies and cheer yourself up. Go for excursions in groups, for outings, camps, conferences, and religious conventions. Get a pet dog and spend time training it, exercising it and relating to it. Expose yourself to some sunlight every day, at least, 30 minutes but not in the scorching heat. Whatever happens, please incorporate these three important adaptations in your life: always be responsible, be respectful, and be functional. If you did these three, lots of things will go well in life. Please pray and have faith in god to alleviate your sufferings. Don?t wait for others to help. Use your own motivation, which might be at its lowest, but persevere and win this battle. Above all to be really happy, you need to live in love and for love. Learn all about emotions and how to handle them and that will get you out of the depression rather easily and quickly. A counselor is there only to facilitate you, all the hard word must come from you, and your cooperation with that person is very critical for your success. Be positive every day and learn to be contented with what you have. Do some left brain exercises: it is the happy brain. Here are a few suggestions: shut your left nostril and breathe, move your eyes from right to left and vice versa for at least half a minute at a time, and do calisthenic exercises with some form of counting, regularly. Whatever happens please cooperate with the therapy and do not discontinue until the condition is completely resolved.  

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Dr. Satheesh Nair SPsychologist32yrs exp

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Hi You need to undergo a re evaluation of the condition to know why treatment resistant. Do check up on physical status like dibeties, Thyroid status etc Also evaluate your mental status and role of stressors or co morbid conditions. Definitely psychological therapies along with medication help you. bye Take care  

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Dr. Saranya DevanathanPsychiatrist50yrs exp

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Dear Sunil, I hope that you have tried these antidepressants in maximum dose and also for at least 3-6 weeks duration. Treatment resistant depression has its own flow chart of add ons like thyroxine, samE, 5 HT and varied therapies. At times review of diagnosis, may be necessary. What antidepressant you are taking now? What is the dose? Since how long, you are on this dose? 

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