I take paroxetine cr on its highest dose, in connection with my anxiety and dysphoria. My doctor told me that I may be having treatment resistant depression and a lot of antidepressants and other augmentation drugs did not work on it. I am 80 percent well by paroxetine and to augment the effects of treatment my psychiatrist lately prescribed me l-methylfolate tablets, 15 mg a day. (7.5�2). Thus, how does l-mythelfolate help in augmenting mood levels? How much days shall I wait to see effects. Taking medication along with counseling. Thanks looking forward to getting your valuable inputs.