I want to consult for my mother, age-53y. Three weeks ago she feels mild aches right lower back side occasionally. So we went to gp two weeks ago, gp suggested for usg whole abdomen and urine culture. Usg report is normal but urine culture found escherichia coli (100000 cfu/ml of unspun urine). But no burning sensation during urine. Antibiogram of culture report: amikacin ? scefotaxime- cefixime- s ciprofloxacin- norfloxacin- ofloxacin- r levofloxacin-i lomefloxacin-imeropenem- moxifloxacin- Inalidixic acid- nitrofurantoin- s gentamycin- spiperac/tazobactam- samplicillin/sulbactam-s (s=sensitive,i=intermediate, r=resistant) gp prescribed - martifur 100 tablet - once for first 3 days, twice for next 12 days. Syp uriliser- 2table spoon 1/2cup water twice but no improvement after two weeks. Again consult with gp, he prescribe - o2 tablet ? twice for 5 days martifur 100 ? once for 10 days. But no improvement. As per antibiogram e.coli has ofloxacin resistant. But gp prescribed o2 tablet (ofloxacin-200 mg). Does o2 tablet works against these strain bacteria? Martifur 100 tablet - once for first 3 days, twice for next 12 days. Can this antibiotic effective because initially 3 days once a day (may be low dose, may bacterial got resistant for low dose)? Please suggest another medicine which would be better.