My close friend's son aged about 39 years is having depression since last 10 to 12 years and the patient taken treatment from different doctors in 3 to 4 hospitals but at the time of taking medicine he is little bit ok but after he leave the medicine it will comes to previous stage. There is some gap between every time he leave and refuse to take the medicine. Now after almost 1 year again they started to take treatment to him, becoz once again he is murmuring with action some times daily, not sleeping properly and abusing over phone to somebody unnecessarily. So, no other option his parents once again started the treatment. Now, the Doctor prescribed the tablets. (1) Cncalm Plus 1-0-1 (2) Soltus 50 mg 0-0-1 (3) Oleanz 2.5 mg 1-0-1. But ongoing taking medicine since one month 10 to 20% better. Now, Trinicalm Plus instead of Cncalm Plus due non-availability of tablets. Is it ok Trinicalm Plus? And the patient is the main earning person in their home, now he is not working since long. Sir, there is no permanent solution for the disease? Or please suggest best medicine for the depression and urgent cure which will be most helpful to their family. Awaiting for your favourable reply Sir.