Dear Doctor, This for my mother who is a 60 year old lady, I would like to know how to tackle the following on going issues in her daily routine. She appears to be detached from her responsibilities. At times agitated and aggressive for no reason Having trouble for letting go of things which needs to be set aside Excessive talking and uncontrolled talking I lost my dad about a year back Bottom Line :- Low self esteem, Low awareness of environment not being socially conscious. Does not like to walk out of house. Negative thoughts. Dark Circles around eyes Facial Contorted expressions.