My dad is suffering from GI junction cancer with liver Mets from Feb 2016. Had 3 cycle of chemotherapy where his numbers and size of tumours reduced by 30 percent. Then after 2 more cycles it reduced by more 50 percent. Then in the month of December it increased by 33 percent. Again dctr advised for chemo. After 3 cycles it reduced slightly but pleural effusion and ascites are seen. Again after 3 cycle secondary cancer increased. Pleural effusion increased. Ascites increased. My question how after chemo cancer is increasing? What are the chances of survival here.

Dr. Dharma Ram PooniaOncologist4yrs exp

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HI lybrate-user, As per your history disease of GI Junction with Liver metastasis, I Presume you want to say about GE junction, Post 2 lines of Chemotherapy and progressive. The overall picture is not happy, it will be advisable to meet the surgical Oncologist if I assume the ascites and pleural effusion is not disease related. If Ascites and Pleural effusion are disease related, which is more a possibility as per case scenario, there are limited options. One vital option would be targeted therapy, with Herceptin if not already instituted in case of Her 2 +ve cancer. Overall with limited information, I feel the picture is quite gloomy. Having said that, ultimate power is GOD, so don't lose hope and Keep fighting. Good luck.  

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