Zigarab LS 75 MG/20 MG Capsule is a combination medication, primarily used for treating ulcerative GERD. It is also prescribed for erosive healing, maintenance of ulcerative GERD, duodenal ulcers, irritable bowel syndrome and chronic gastritis. Recently, it has also come to be used in the treatment of hypersecretory conditions that include Zollinger-Ellison syndrome.
On using Zigarab LS 75 MG/20 MG Capsule the associated side effects that you may suffer from are disorientation, delirium, the elevation of thyroid-stimulating hormone (TSH), rhabdomyolysis, bullous, erythema multiforme, drug-induced diarrhoea, twitching, tremor, weight gain or akathisia.
In certain severe cases, you may experience jaundice, interstitial pneumonia, tardive dyskinesia, gynecomastia (a disorder of the endocrine system where there is an enlargement of the male breast size). In the latter case it will be necessary for you to seek medical attention.
Before using this medication it is advised that you consult your doctor and tell him/her if you had/have or are:
- Pregnant, or are planning to become pregnant.
- Nursing a baby
- Taking any prescriptive or over the counter drugs, herbals medications or dietary supplements.
- A recent surgery or are scheduled for one in the near future.
- Pheochromocytoma or gastrointestinal perforation.
- A history of cancer-related disease.
- A history of epilepsy or any other kind of seizures.
- Allergic to any medicine, food or substance.
The dosage of this medication will be as prescribed by your doctor as per the severity of your condition, your age, gender and overall medical history. But commonly a dose of 25 mg of this medicine is prescribed which needs to be taken three times in a day. Results may start to show within an hour or two of using. In case of drug overdose notify your physician right away.
The medicine is useful against the following conditions:
Gastroesophageal Reflux DiseaseThis medicine is used for the treatment of gastroesophagal reflux disease marked by increased irritation of the stomach caused by bile and acid.
- stomach pain, flatulence, diarrhea, or constipation.
Duodenal UlcerThis medicine is used for the treatment of duodenal ulcer marked by severe abdominal pain, heartburn, indigestion, bloating, belching, nausea or vomiting.
- agitation, depression, hallucinations etc.
Gastrointestinal PerforationsThis medicine is not recommended for use if you have a condition where the food pipe and the gut is bleeding, obstructed, and perforated.
Here are some of the possible side effects of this medicine:
How long is the duration of effect?The effect of this medicine lasts for an average duration of 5-8 hours upon oral administration.
What is the onset of action?The effect of this medicine can be observed within 1-2 hours of oral administration.
Are there any pregnancy warnings?Use of this medicine during pregnancy is not recommended unless absolutely necessary. It is advised to use this medicine only when the benefits outweigh the risks involved.
Is it habit forming?No habit forming tendencies were reported.
Are there any breast-feeding warnings?Use of this medicine by breastfeeding women is not recommended. However, if it is absolutely necessary to use this medicine, then breastfeeding should be discontinued. Consult your doctor before using this medicine.
Below is the list of medicines, which have the same composition, strength and form as Zigarab LS 75 MG/20 MG Capsule , and hence can be used as its substitute.
Are there any missed dose instructions?Take the missed dose as soon as you remember. If it is almost time for the next scheduled dose, then the missed dose can be skipped.
Are there any overdose instructions?Contact a doctor if an overdose with Zigarab LS 75 MG/20 MG Capsule is suspected. Symptoms of an overdose may include excessive drowsiness, fall in blood pressure, agitation, coma etc.
This medicine is a combination of Levosulpiride and Rabeprazole. These two belongs to neuroleptic and PPI class respectively. Thus this medicine works via the dual mechanism.
Firstly, it works by selectively binding to dopamine receptors in the brain and the periphery. This action results in an increased tone of muscles in the gastrointestinal tract. Secondly, it binds to H+/K+-exchanging ATPase in gastric parietal cells, resulting in blockage of acid secretion.
Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.
Interaction with Alcohol
EthanolAvoid or limit the uptake of alcohol while taking this medicine as the risk of adverse effects are increasingly high. Contact your doctor if an excess of drowsiness is experienced.
Interaction with Lab Test
Prolactin testReport the use of this medicine before undergoing a laboratory test to determine the levels of the hormone prolactin in the body. This medicine can interfere with the test and yield false positive results.
Interaction with Medicine
DiltiazemReport the use of diltiazem or any other medicine taking for managing high blood pressure to the doctor. These medicines should be used with caution as the risk of adverse effects are increasingly high. Your doctor may determine the best course of treatment after assessing the conditions.
PregabalinReport the use of either of the medicine to the doctor. You may require a dose adjustment and more frequent monitoring while using these medicines together. Do not stop the use of any medicine without consulting your doctor.
SucralfateReport the use of either of the medicine to the doctor. You may require a dose adjustment and frequent clinical monitoring while using these medicines together. Do not stop the use of any medicine without consulting your doctor.
TramadolReport the use of any narcotic pain-killer medicine to the doctor. These medicines should be used with extreme caution as the risk of adverse effects are significantly high. Your doctor may decide the best course of treatment after assessing the conditions.
Aluminium Hydroxide/Magnesium HydroxideReport the use of any aluminum or magnesium containing antacids to the doctor before receiving this medicine. You may need a dose adjustment and frequent clinical monitoring to safely use these medicines together.
IpratropiumReport the use of either of the medicine to the doctor. You may require a dose adjustment and more frequent monitoring while using these medicines together. Do not stop the use of any medicine without consulting your doctor.
WarfarinConcomitant use of this medication with warfarin causes an increase in INR and prothrombin time. This leads to abnormal bleeding and even death.
CyclosporineIf concomitantly administered, this medication inhibits the metabolism of cyclosporine and creates its concentration to be over 50 times higher than its normal Cmax.
Other medicationsIts action on GI motility could also be antagonized by concomitant use of narcotics, anticholinergic agents and analgesics.
Interaction with Disease
Heart DiseasesThis medicine should be used with caution in patients suffering from a disease of the heart and blood vessels. You may require an adjusted dose and safety monitoring to safely use this medicine.nausea, vomiting, presence of blood in stool to the doctor.
Prolactin ImbalanceThis medicine should not be used in patients having an abnormal level of the hormone prolactin. Breast cancer due to a high level of prolactin should be ruled out before treatment with this medicine is initiated.
Neuroleptic Malignant Syndrome (Nms)Use of this medicine is not recommended if the patient suffers from Neuroleptic malignant syndrome. Introduction or reintroduction of this medicine should be done with caution in patients having a known history of this syndrome.asthma. Report any instances of difficulty in breathing, wheezing, chest pain etc to the doctor immediately.
Interaction with Food
FoodInformation not available.
Ques: What is Zigarab LS 75 MG/20 MG Capsule?
Ques: What is the use of Zigarab LS 75 MG/20 MG Capsule?
- Healing of erosive or ulcerative gastro-oesophageal reflux disease (GERD)
- Maintenance of healing of erosive or ulcerative GERD
- Healing of duodenal ulcers
- Treatment of pathological hypersecretory conditions, including Zollinger- Ellison syndrome
- Irritable bowel syndrome
- Chronic gastritis
Ques: What are the side effects of Zigarab LS 75 MG/20 MG Capsule?
Ques: How long do I need to use Zigarab LS 75 MG/20 MG Capsule before I see improvement in my condition?
Ques: At what frequency do I need to use Zigarab LS 75 MG/20 MG Capsule?
Ques: Should I use Zigarab LS 75 MG/20 MG Capsule empty stomach, before food or after food?
Ques: What are the instructions for the storage and disposal of Zigarab LS 75 MG/20 MG Capsule?
Levosulpiride- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2020 [Cited 23 January 2020]. Available from:https://druginfo.nlm.nih.gov/drugportal/name/levosulpiride
Rabeprazole- Drug Information Portal [Internet]. druginfo.nlm.nih.gov. 2020 [Cited 23 January 2020]. Available from:https://druginfo.nlm.nih.gov/drugportal/rn/117976-89-3
New Drugs Approved by CDSCO, Central Drugs Standard Control Organisation, Government of India [Internet]. cdscoonline.gov.in [Cited 23 January 2020]. Available from:https://cdscoonline.gov.in/CDSCO/Drugs
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