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Overview

Prednisolone  40 MG Tablet

Prednisolone 40 MG Tablet

Manufacturer: Pfizer Ltd
Medicine composition: Prednisolone
Prescription vs.OTC: Prescription by Doctor required

Prednisolone 40 MG Tablet is known to be a corticosteroid that helps to prevent the release of some substances in the body that lead to inflammation. The drug helps in the treatment of a number of conditions like skin problems, arthritis, breathing disorders, psoriasis, lupus and allergic reactions.

Before starting the steroid it is important that you are aware of generic information about it. For instance, Prednisolone 40 MG Tablet should not be taken if you are allergic to it or any component it has. Prednisolone 40 MG Tablet should also not be taken if you have a fungal infection.

The doctor should be aware of your medical history, including any allergies or health issues that you suffer from. Let your doctor know if you have cirrhosis, diabetes, thyroid issues, kidney disease, depression, hypertension, heart problems or muscle disorders. The doctor will then determine if Prednisolone 40 MG Tablet is safe for your body and will prescribe a calculated dose. Although it has not been established if the steroid harms an unborn child, doctors do not generally recommend Prednisolone 40 MG Tablet to pregnant women or even mothers who are breast feeding.

Prednisolone 40 MG Tablet should be taken as per instructions on the prescription. Do not take a lower or higher dose without consulting your doctor. Initially the doctor may start the drug with a low dosage and then prescribe higher doses depending on your health and your body?s reaction to the drug. The drug is available in the form of oral suspension as well as tablets. When taking the liquid form of Prednisolone 40 MG Tablet shake the bottle well before measuring the required dose. Tablets should be stored in blister packs, and should be handled with dry hands. Do not chew the tablet, place it in your mouth and let it dissolve. You can have water to effectively swallow the drug. In case you need to stop the drug, do it gradually, suddenly discontinuing Prednisolone 40 MG Tablet can lead to problems.

Gouty arthritis
Prednisolone 40 MG Tablet is used in the treatment of gouty arthritis which is a type of joint inflammation. Severe pain, redness are few symptoms of gouty arthritis.
Prednisolone 40 MG Tablet is used in the treatment of psoriasis which is a type of skin disease. Itchy or sore patches and red skin are few symptoms of psoriasis.
Prednisolone 40 MG Tablet is used in the treatment of nephrotic syndrome which is a type of kidney disease. Swelling of face, skin rash are few symptoms of nephrotic syndrome.
Prednisolone 40 MG Tablet is used in the treatment of rheumatoid arthritis. Swelling, pain, and stiffness of joints are few symptoms of Rheumatoid Arthritis.
Prednisolone 40 MG Tablet is used in the treatment of asthma which is an inflammation of the airways. Wheezing, cough, difficulty in breathing are few symptoms of asthma.
Avoid if you have a known allergy to Prednisolone 40 MG Tablet or any other glucocorticoids.
Systemic infections
Avoid if you have any fungal or eye infections.
In addition to its intended effect, Prednisolone 40 MG Tablet may cause some unwanted effects too. In such cases, you must seek medical attention immediately. This is not an exhaustive list of side effects. Please inform your doctor if you experience any adverse reaction to the medication.
Aggression or anger Major Common
Blurred vision Major Common
Decreased urine output Major Common
Dizziness Major Common
Headache Major Common
Weight gain Major Common
Fast heartbeat Major Common
Increased appetite Minor Common
How long is the duration of effect?
The effect of this medicine lasts for a duration of 8 to 9 hours.
What is the onset of action?
The peak effect of this medicine is observed within 5 minutes after an intravenous dose and 1 hour after an oral dose.
Are there any pregnancy warnings?
This medicine is recommended for pregnant women only if clearly needed and if no other safer alternative is available.
Is it habit forming?
No habit forming tendencies were reported.
Are there any breast-feeding warnings?
This medicine is known to excreted through breast milk in small amounts. Use this medicine only if clearly needed when no other safer alternative is available.
Below is the list of medicines, which have the same composition, strength and form as Prednisolone 40 MG Tablet, and hence can be used as its substitute.
Pfizer Ltd
Mankind Pharmaceuticals Ltd
Macleods Pharmaceuticals Pvt.Ltd
Cipla Ltd
Missed Dose instructions
The missed dose can be taken as soon as you remember. However, the missed dose should be skipped if it is almost time for your next dose.
Overdose instructions
Seek emergency medical treatment or contact the doctor in case of an overdose.
India
United States
Japan
Whenever you take more than one medicine, or mix it with certain foods or beverages, you're at risk of a drug interaction.
Interaction with Disease
Gastro-intestinal bleeding Major
Prednisolone 40 MG Tablet is used with caution in the patients with gastrointestinal diseases. The risk of bleeding is more when taken for a long duration of time. Dose adjustments are to be made based on the clinical condition.
Diabetes Moderate
Prednisolone 40 MG Tablet is used with caution in the patients with diabetes as it increases the blood glucose levels. Regular monitoring of blood glucose levels is necessary. A suitable antidiabetic agent should be prescribed based on the clinical condition.
Interaction with Alcohol
Alcohol
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Lab Test
Lab
Information not available.
Interaction with Food
Food
Information not available.
Interaction with Medicine
Ethinyl Estradiol Moderate
Use with caution as this combination will increase the concentration of Prednisolone 40 MG Tablet. Inform the doctor if you are taking either of the medicines. Consider an alternative medicine or dose adjustments after consulting your doctor.
Azole antifungal agents Moderate
Use of ketoconazole and itraconazole should be avoided as these medicines may increase the concentration of Prednisolone 40 MG Tablet in the body which may cause swelling, high blood glucose, weight gain, and growth abnormalities in the children. Dose adjustments or an alternative medicine should be considered based on the clinical condition.
Antihypertensives Moderate
Use with caution as this combination will decrease the concentration of Antihypertensives. This interaction is more likely to occur if Prednisolone 40 MG Tablet is taken for more than a week. Inform the doctor if you are taking either of the medicines. Consider an alternative medicine or dose adjustments after consulting your doctor.
Nonsteroidal anti-inflammatory drugs Moderate
Use with caution as this combination will increase the risk of gastrointestinal bleeding. Inform the doctor if you are taking either of the medicines. Consider taking alternative medicine after consulting your doctor.
Fluoroquinolone Major
You may experience pain, swelling, or inflammation in ankle, shoulder, hand, or thumb if these medicines are used together. This interaction is more likely to occur in elderly population who have undergone a kidney or heart transplantation. Replacement of the medicine should be made under the doctor's supervision.

Popular Questions & Answers

Hi, Please suggest. Can prednisolone 30 mg be given for a patient of bronchitis patient of 72 year old women of 33 kg weight?

MBBS, MD TUBERCULOSIS AND CHEST DISEASES, Diploma in Tuberculosis & Chest Diseases, Diploma in Tropical Medicine and Hygiene
Pulmonologist, Kolkata
If the condition of the patient is serious then prednisolone 30 mg /day may be necessary to tide over the crisis.

I was in Delhi for 6 months. From last 40 days there is some blockage in my nose. It looks like polyps. I have visited 3 ENT doctors. One said it's Allergic Rhinitis, others said it's due to allergy. I have used steroid sprays, Prednisolone,and almost all kind of medicines, but they haven't shrink a bit. What can I do? Last doctor prescribed taking antibiotics, paracetamol,antihistamines, Prednisolone and few other medicines and a nasal spray twice daily for 15 days which I am taking currently.

Mbbs, Ent dnb
ENT Specialist, Anantapur
I was in Delhi for 6 months. From last 40 days there is some blockage in my nose. It looks like polyps. I have visite...
Dear lybrate-user Those you see in the mirror are nasal turbinates and not polyps. They wont shrink because they are there since birth. You don't need to be bothered by them unless you don't have relief in nasal blockage. These turbinates are very essential in air conditioning of all types of air you inhale into lungs. So stop looking at them and just look at the difficulties in breathing or sneezing or any allergy symptoms. Ask your doctor about your doubts and get them cleared when you take a review with him. Don't change doctors frequently. Get well soon.

My wife is attacked by facial palsy and doctor has advised wysolone 10 mg three times and neurobion forte two times, her lab report like diabetes, thyroid, lipid profile, ecg all are normal. Daily mm level improvement is noticed. So still how many days it will take to cure and will you please suggest any exercises for facial palsy.

MBBS, CCEBDM, Diploma in Diabetology, Diploma in Clinical Nutrition & Dietetics, Cetificate Course In Thyroid Disorders Management (CCMTD)
Endocrinologist, Hubli-Dharwad
Hello, Thanks for te query. Bell's palsy most often recovers spontaneously. Corticosteroids (prednisolone) is used with in 72 hours of occurrence. Total duration should be about 10 days. Thanks.

Popular Health Tips

Who Is At Risk Of Osteoporosis?

DNB (Orthopedics), MS - Orthopaedics
Orthopedist, Visakhapatnam
Who Is At Risk Of Osteoporosis?

Osteoporosis is a condition which usually results due to a decrease in bone density. In this condition, the bones become weak and brittle. Fractures are a common result of osteoporosis. Usually, symptoms or signs do not show up until the condition progresses to its advanced stages.

Since osteoporosis is usually irreversible and incurable, preventing the fractures is considered to be extremely important.

Who is at risk of osteoporosis?
All men and women have some risk of developing 'thinning' of the bones (osteoporosis) as they become older, particularly over the age of 60. As mentioned above, women are more at risk than men. The following situations may also lead to excessive bone loss and so increase your risk of developing osteoporosis. If you:

  1. Are a woman who had the menopause before 45 years of age
  2. Have already had a bone fracture after a minor fall or bump
  3. Have a strong family history of osteoporosis.
  4. Have a body mass index (BMI) of 19 or less (that is, you are very underweight)
  5. Have irregular periods
  6. Have taken, or are taking, a steroid medicine (such as prednisolone) for three months or more
  7. Are a smoker
  8. Have an alcohol intake of more than four units per day
  9. Lack calcium and/or vitamin D (due to a poor diet and/or little exposure to sunlight).
  10. Are mostly inactive

Ways To Treat Osteporosis

Osteoporosis in women can be treated using Hormone Replacement Therapy (HRT). The therapy makes use of either a combination of progestin and oestrogen or simply, oestrogen. However, it is possible that certain combinations have side-effects that might give rise to other medical conditions. Therefore, proper consultation with an orthopedist is an essential pre-requisite so that the condition of osteoporosis as well the side effects may be addressed before proceeding with Hormone Replacement Therapy.

There are a number of medications that can be used which have long-term effects on osteoporosis. However, the schedule for intake of these medicines should be followed diligently. Failing to adhere to the schedule could lead to serious complications. For example, the intake of Risedronate medications (prevent bone loss) should be scheduled once every month, failing which can cause ulcers in the food pipe. Raloxifene has effects which are similar to oestrogen but does not exhibit any serious side effects. Teriparatide can be used to treat osteoporosis in people who have a high risk of suffering from bone fractures.

Don't rely entirely on medication as the only treatment for your osteoporosis. These practices also are important:

  1. Exercise. Weight-bearing physical activity and exercises that improve balance and posture can strengthen bones and reduce the chance of a fracture. The more active and fit you are as you age, the less likely you are to fall and break a bone.
  2. Good nutrition. Eat a healthy diet and make certain that you're getting enough calcium and vitamin D. Being underweight or losing a lot of weight unintentionally is associated with poorer bone health and a higher risk of fracture — even if you're taking a bisphosphonate.
  3. Quit smoking. Smoking cigarettes speed up bone loss.
  4. Limit alcohol. If you choose to drink alcohol, do so in moderation. For healthy adults, that means up to one drink a day for women of all ages and men older than age 65, and up to two drinks a day for men age 65 and younger.

In case you have a concern or query you can always consult an expert & get answers to your questions!

2656 people found this helpful

Giant Hives: What Are The Causes Behind?

MBBS, MD - Dermatology , Venereology & Leprosy, Cosmetologist
Dermatologist, Chandigarh
Giant Hives: What Are The Causes Behind?

Allergic reactions are the body’s way of responding to foreign substances. The body recognizes these substances (be it food, pollens, insect bites, etc.) as antigens and produces antibodies. These antibodies can cause various reactions depending on the severity of the allergen, be it skin rash, hives, or angioedema. In severe cases, there could be swelling of the tongue and the respiratory tract, leading to choking of the airways.

Literally, angioedema means swelling of the blood vessels. These are located in the underlying layers of the skin and their swelling can lead to formation of giant hives, which can be extremely itchy, reddish, and oval or circular in shape. The affected area is usually warm and painful to touch.

Causes

Angioedema is caused due to the following:

  1. Food allergies including eggs, peanuts, shellfish, milk, tree nuts, chocolates, etc.

  2. Insect bites or stings

  3. Pollen, latex, animal dander, poison ivy, and other common allergens

  4. Medications like aspirin, penicillin, ibuprofen, and some blood pressure medicines

  5. In response to blood transfusions

  6. Auto-immune disorders like lupus

  7. Conditions like leukemia and thyroid disorders

  8. Infections like hepatitis, cytomegalovirus infections, Epstein-Barr infections, etc.

  9. Weather conditions like extremes of cold, heat, or pressure

  10. Extreme emotional stress

  11. Genetic angioedema, passed on from parents to children, which could last forever

While hives usually develop without any warning, the following condition puts a person at risk of developing angioedema.

  1. Predisposition to allergic reactions (highly active immune system)

  2. Previous history of allergies

  3. Genetic history of allergies or angioedema

Most angioedema cases are limited to the skin and hives, but there could be severe cases leading to respiratory distress.

Diagnosis

If it is the first instance of hives, the doctor would ask detailed questions about similar occurrence in the past. They would also check if there are similar hives on other parts of the body like the back, which you may have missed. If required, this examination is followed by allergy testing and blood testing. The allergy testing will help identify if you are allergic to some of the common things which cause allergy. The blood test will look for your eosinophil count, which is usually high in people prone to allergies. C1 esterase inhibitor test and complement particles also can be checked, if there is suspicion of genetic angioedema.

Treatment

This would depend on the severity of symptoms

  1. In case of angioedema, admission in hospital may be needed.
  2. Tracheostomy may also become essential to save patients life.
  3. Vigorous therapy with intravenous medications like steroid, antihistamines and others may be needed.
  4. Under medical treatment, antihistamines like cetirizine and loratadine are prescribed. However, severe cases may require steroids like prednisolone.

Prevention

Once you know what caused it, avoid exposure to these substances and further attacks can be prevented. If you wish to discuss about any specific problem, you can consult a Dermatologist.

2603 people found this helpful

Unhealthy Bones at Old Age - How to Prevent it?

DNB (Orthopedics), Diploma in Orthopaedics, MBBS
Orthopedist, Mumbai
Unhealthy Bones at Old Age - How to Prevent it?

Bones play a significant role in our body. They make our structure and help in organ protection, anchoring the muscles and storing calcium. From childhood to adulthood, bones are continuously changing. While new bones are generated, the old bones are torn down. So, it is important to keep our bones healthy with the advancement of old age. There are many ways by which we can avoid unhealthy bones in old age. Some of these ways have been discussed below:

Adequate amount of calcium intake in our body greatly influences healthy bone with good bone density and mitigate the risk of osteoporosis and bone fractures in old age. Older adults need 1,200 mg of calcium a day by having milk, yogurt or cheese. We should also include non-dairy products like tofu, broccoli, almonds, and green leafy vegetables. These items contain Vitamin D, which help the body in absorbing and process calcium. Good sources of calcium are dairy products and fish such as sardines and salmon.

According to the Institute of Medicine, 1,000 mg of calcium a day is needed for most adults and 1,200 mg/day for women after menopause and men after 70. Adults that are 70 years and older require 800 IU of vitamin D a day to in order to prevent falls and fractures.

Physical Activity: Physical activity reduces the risk of osteoporosis and keeps your bone mobility healthy and strong. According to research, avoiding use of tobacco and alcohol contributes healthy bones. Consumption of these poses threat to the health of the bones. Alcohol increases the risk of osteoporosis as it has the ability to interfere with the body’s absorption of calcium.
Eating disorders and other conditions: People with anorexia or bulimia are at risk of bone loss. In addition, stomach surgery (gastrectomy), weight-loss surgery and conditions such as Crohn's disease, celiac disease and Cushing's disease can affect your body's ability to absorb calcium. So, one should have a healthy diet and maintain a disciplined life.

Certain medications: Long-term use of corticosteroid medications, such as prednisone, cortisone, prednisolone and dexamethasone, are damaging to bone. Other drugs that might increase the risk of osteoporosis include aromatase inhibitors to treat breast cancer, selective serotonin reuptake inhibitors, methotrexate, some anti-seizure medications, such as phenytoin (Dilantin) and phenobarbital, and proton pump inhibitors. So, while taking medicines one should consult doctor so as to avoid those medicines for long term which affect bone’s health. While taking these medications one should eat adequate amount of calcium as medicine and food in order to minimize the side effects.

Avoid taking caffeine as it makes our body to excrete calcium more quickly. So drink less regular coffee, tea and soft drinks and avoid high caffeine energy drinks. Avoid using salty foods that causes loss of calcium and weakens the bone. Foods that are processed and canned have high salt, so avoid eating these foods.

6 people found this helpful

Angioedema - An Overview

MBBS(Hons), MD (Gold Medalist) Dermatology
Dermatologist, Kolkata
Angioedema - An Overview

Allergic reactions are the body’s way of responding to foreign substances. The body recognizes these substances (be it food, pollens, insect bites, etc.) as antigens and produces antibodies. These antibodies can cause various reactions depending on the severity of the allergen, be it skin rash, hives, or angioedema. In severe cases, there could be swelling of the tongue and the respiratory tract, leading to choking of the airways.

Literally, angioedema means swelling of the blood vessels. These are located in the underlying layers of the skin and their swelling can lead to formation of giant hives, which can be extremely itchy, reddish, and oval or circular in shape. The affected area I usually warm and painful to touch.

Causes

Angioedema is caused due to the following:

  1. Food allergies including eggs, peanuts, shellfish, milk, tree nuts, chocolates, etc.

  2. Insect bites or stings

  3. Pollen, latex, animal dander, poison ivy, and other common allergens

  4. Medications like aspirin, penicillin, ibuprofen, and some blood pressure medicines

  5. In response to blood transfusions

  6. Auto-immune disorders like lupus

  7. Conditions like leukemia and thyroid disorders

  8. Infections like hepatitis, cytomegalovirus infections, Epstein-Barr infections, etc.

  9. Weather conditions like extremes of cold, heat, or pressure

  10. Extreme emotional stress

  11. Genetic angioedema, passed on from parents to children, which could last forever

While hives usually develop without any warning, the following condition puts a person at risk of developing angioedema.

  1. Predisposition to allergic reactions (highly active immune system)

  2. Previous history of allergies

  3. Genetic history of allergies or angioedema

Most angioedema cases are limited to the skin and hives, but there could be severe cases leading to respiratory distress.

Diagnosis

If it is the first instance of hives, the doctor would ask detailed questions about similar occurrence in the past. They would also check if there are similar hives on other parts of the body like the back, which you may have missed. If required, this examination is followed by allergy testing and blood testing. The allergy testing will help identify if you are allergic to some of the common things which cause allergy. The blood test will look for your eosinophil count, which is usually high in people prone to allergies. C1 esterase inhibitor test and complement particles also can be checked, if there is suspicion of genetic angioedema.

Treatment

This would depend on the severity of symptoms

  1. In case of angioedema, admission in hospital may be needed.
  2. Tracheostomy may also become essential to save patients life.
  3. Vigorous therapy with intravenous medications like steroid, antihistamines and others may be needed.
  4. Under medical treatment, antihistamines like cetirizine and loratadine are prescribed. However, severe cases may require steroids like prednisolone.

Prevention

Once you know what caused it, avoid exposure to these substances and further attacks can be prevented. If you wish to discuss about any specific problem, you can consult a doctor.

2150 people found this helpful

Curing Long Term Osteoporosis

M.Ch - Orthopaedics - , MS - Orthopaedics, MBBS
Orthopedist, Delhi
Curing Long Term Osteoporosis

Osteoporosis is a condition which usually results due to a decrease in bone density. In this condition, the bones become weak and brittle. Fractures are a common result of osteoporosis. Usually, symptoms or signs do not show up until the condition progresses to its advanced stages.

Since osteoporosis is usually irreversible and incurable, preventing the fractures is considered to be extremely important.

Who is at risk of osteoporosis?
All men and women have some risk of developing 'thinning' of the bones (osteoporosis) as they become older, particularly over the age of 60. As mentioned above, women are more at risk than men. The following situations may also lead to excessive bone loss and so increase your risk of developing osteoporosis. If you:

  1. Are a woman who had the menopause before 45 years of age
  2. Have already had a bone fracture after a minor fall or bump
  3. Have a strong family history of osteoporosis.
  4. Have a body mass index (BMI) of 19 or less (that is, you are very underweight)
  5. Have irregular periods
  6. Have taken, or are taking, a steroid medicine (such as prednisolone) for three months or more
  7. Are a smoker
  8. Have an alcohol intake of more than four units per day
  9. Lack calcium and/or vitamin D (due to a poor diet and/or little exposure to sunlight).
  10. Are mostly inactive

Ways To Treat Osteporosis

Osteoporosis in women can be treated using Hormone Replacement Therapy (HRT). The therapy makes use of either a combination of progestin and oestrogen or simply, oestrogen. However, it is possible that certain combinations have side-effects that might give rise to other medical conditions. Therefore, proper consultation with an orthopedist is an essential pre-requisite so that the condition of osteoporosis as well the side effects may be addressed before proceeding with Hormone Replacement Therapy.

There are a number of medications that can be used which have long-term effects on osteoporosis. However, the schedule for intake of these medicines should be followed diligently. Failing to adhere to the schedule could lead to serious complications. For example, the intake of Risedronate medications (prevent bone loss) should be scheduled once every month, failing which can cause ulcers in the food pipe. Raloxifene has effects which are similar to oestrogen but does not exhibit any serious side effects. Teriparatide can be used to treat osteoporosis in people who have a high risk of suffering from bone fractures.

Don't rely entirely on medication as the only treatment for your osteoporosis. These practices also are important:

  1. Exercise. Weight-bearing physical activity and exercises that improve balance and posture can strengthen bones and reduce the chance of a fracture. The more active and fit you are as you age, the less likely you are to fall and break a bone.
  2. Good nutrition. Eat a healthy diet and make certain that you're getting enough calcium and vitamin D. Being underweight or losing a lot of weight unintentionally is associated with poorer bone health and a higher risk of fracture — even if you're taking a bisphosphonate.
  3. Quit smoking. Smoking cigarettes speed up bone loss.
  4. Limit alcohol. If you choose to drink alcohol, do so in moderation. For healthy adults, that means up to one drink a day for women of all ages and men older than age 65, and up to two drinks a day for men age 65 and younger.
4699 people found this helpful