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Leflunomide

Prescription vs.OTC: Prescription by Doctor required

Leflunomide is an immunosuppressive disease-modifying antirheumatic drug. It is a pyrimidine synthesis inhibitor. It is used to treat rheumatoid arthritis. It functions by reducing joint pain and swelling.

Certain side-effects that you may experience on using Leflunomide are dizziness, nausea, diarrhoea, hair loss, headache, respiratory tract infections, cough, difficulty breathing, stomatitis, fatigue, itchiness and pharyngitis. Should your allergic reactions continue or worsen over time, immediately contact your health care provider.

Before using Leflunomide have a word with your doctor and inform him/her if: you are allergic to any medication, food, substance or any ingredient contained within Leflunomide, you are pregnant, or are planning to become pregnant or are nursing a baby, you have a weak immune system, you have liver, lung or kidney problems and if you are taking any prescription or non-prescription drugs.

The dosage should be ideally prescribed by your doctor. This medication comes in a tablet form. Usually the adult dose for Leflunomide is about 20 mg (maintenance dose) to be taken through the mouth once for over a period of 3 days.

Information given here is based on the salt and content of the medicine. Effect and uses of medicine may vary from person to person. It is advicable to consult a Rheumatologist before using this medicine.

In addition to its intended effect, Leflunomide may cause some unwanted effects too. In such cases, you must seek medical attention immediately. This is not an exhaustive list of side effects. Please inform your doctor if you experience any adverse reaction to the medication.

Headache

Dyspepsia

Rash

Increased liver enzymes

Respiratory tract infection.

Is It safe with alcohol?

Taking Leflunomide with alcohol may cause liver problems.

Are there any pregnancy warnings?

Lefra 20mg tablet is highly unsafe to use during pregnancy.
Human and animal studies have shown significant adverse effects on the foetus. Please consult your doctor.

Are there any breast-feeding warnings?

Unknown. Human and animal studies are not available. Please consult your doctor.

Is it safe to drive while on this medicine?

Caution is advised when driving or operating machinery.

Does this affect kidney function?

There is no data available. Please consult doctor before consuming the drug.

Does this affect liver function?

There is no data available. Please consult doctor before consuming the drug.

Are there any missed dose instructions?

If you miss a dose of Leflunomide, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Below is the list of medicines, which contains Leflunomide as ingredient
Sanofi India Ltd
Ronyd Healthcare Pvt Ltd
Sun Pharmaceutical Industries Ltd
Ronyd Healthcare Pvt Ltd
Overseas Healthcare Pvt Ltd
Ipca Laboratories Ltd
Zydus Cadila
Ranbaxy Laboratories Ltd
Ipca Laboratories Ltd
Sun Pharmaceutical Industries Ltd
Torrent Pharmaceuticals Ltd
Sanofi India Ltd
Zydus Cadila
Ronyd Healthcare Pvt Ltd
Wallace Pharmaceuticals Pvt Ltd
Torrent Pharmaceuticals Ltd
Overseas Healthcare Pvt Ltd
Ipca Laboratories Ltd
Rhumasafe Pharmaceutical
Leflunomide is a prodrug with anti-inflammatory and immunosuppressive properties that works by breaking down into its active metabolite A77 1726 once ingested which then blocks an important enzyme for de novo pyrimidine synthesis, dihydroorotate dehydrogenase. This inhibits the growth of activated T-lymphocytes.
Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

Interaction with Medicine

Troykcl 1.5Gm Injection

Zyvana 1Mg Tablet

What are you using Leflunomide for?
Rheumatoid Arthritis
Other
How much was the improvement?
Excellent
Poor
Average
How long did it take before seeing improvement?
More than 2 days
Within 2 hours
Within 6 hours
How frequently did you take this medicine?
Once a day
Twice a day
How did you take this medicine?
With Food
What were the side effects of this medicine?
Rash
Dyspepsia
Other
Diarrhoea
Increased liver enzymes
Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

Popular Questions & Answers

I am 25 male. I have pain in my rib cage, arm and neck. My ra factor is 44 and using leflunomide can I do gym regularly and how can I make ra vanish. Please.

CCP, MBA, Bachelor of Ayurveda, Medicine and Surgery (BAMS)
Ayurveda, Karnal
You are suffering from aama & kapha dosha as per ayurveda. For removing this you need complete body detoxification by vaman & virechana, followed by rooksha swedana & vaitaran vasti. Please consult a panchakarma expert near you.
1 person found this helpful

I am ra positive since last 7 yrs my right foot is in pain since last 25 days previously it used to move around in my body I hope it's not the critical stage of disease I m taking methotrexate 10 mg weeklyand leflunomide10 mg every day please help.

MBBS, MS - Orthopaedics
Orthopedist, Delhi
Kindly show me a photograph & digital x rays of affected part. Rule out diabetes & vit. D deficiency or any other metabolic disorder. Sleep on a hard bed with soft bedding on it. Spring beds, folding beds or thick matress are harmful use no pillow...

Sir. My mother is a rhutd- arthrities patient and taking prednisolone, hcq, leflunomide, shelcal 500 regularly. My question is if she stops taking prednisolene for some time will it affect? another one is, taking regular calcium tablet, can it create stone in the stomach? your advice please.

MBBS, MS - Orthopaedics
Orthopedist, Delhi
Prednisolone should be weaned off gradually. Continue with other medicimes as before until all symptoms are controlled. Kindly show me photograph& the x rays of the affected part. Rule out diabetes & vit. D deficiency or any other metabolic disord...
3 people found this helpful

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Table of Content
About Leflunomide
When is Leflunomide prescribed?
What are the side effects of Leflunomide ?
Key highlights of Leflunomide
What are the dosage instructions?
Medicines containing Leflunomide
How does medicine works?
What are the interactions for Leflunomide ?