Dm Lef 10Mg Tablet
Dm Lef 10Mg Tablet is an immunosuppressive disease-modifying antirheumatic drug. It is a pyrimidine synthesis inhibitor. It is used to treat rheumatoid arthritis. It functions by reducing joint pain and swelling.
Certain side-effects that you may experience on using Dm Lef 10Mg Tablet are dizziness, nausea, diarrhoea, hair loss, headache, respiratory tract infections, cough, difficulty breathing, stomatitis, fatigue, itchiness and pharyngitis. Should your allergic reactions continue or worsen over time, immediately contact your health care provider.
Before using Dm Lef 10Mg Tablet have a word with your doctor and inform him/her if: you are allergic to any medication, food, substance or any ingredient contained within Dm Lef 10Mg Tablet, you are pregnant, or are planning to become pregnant or are nursing a baby, you have a weak immune system, you have liver, lung or kidney problems and if you are taking any prescription or non-prescription drugs.
The dosage should be ideally prescribed by your doctor. This medication comes in a tablet form. Usually the adult dose for Dm Lef 10Mg Tablet is about 20 mg (maintenance dose) to be taken through the mouth once for over a period of 3 days.
If diabetic, monitor blood sugars closely; this medication may alter glucose levels. There is no human experience with overdosage. Dm Lef 10Mg Tablet is not dialyzable. Cholestyramine and/or activated charcoal enhance elimination of leflunomide's active metabolite (MI).
In cases of significant overdose or toxicity, cholestyramine 8 g every 8 hours for 1-3 days may be administered to enhance elimination. Plasma levels are reduced by approximately 40% in 24 hours and 49% to 65% after 48 hours of cholestyramine dosing.
Take as directed; do not increase dose without consulting prescriber. Maintain adequate hydration (2-3 L/day of fluids unless instructed to restrict fluid intake). Store medication away from light.
Dm Lef 10Mg Tablet has been associated with teratogenic and embryolethal effects in animal models at low doses. Dm Lef 10Mg Tablet is contraindicated in pregnant women or women of childbearing potential who are not using reliable contraception.
Pregnancy must be excluded prior to initiating treatment. Following treatment, pregnancy should be avoided until the drug elimination procedure is completed.
The primary use of this medication is as follows:
Is It safe with alcohol?Taking Dm Lef 10Mg Tablet with alcohol may cause liver problems.
Are there any pregnancy warnings?Dm Lef 10Mg Tablet is highly unsafe to use during pregnancy.
Human and animal studies have shown significant adverse effects on the foetus. Please consult your doctor.
Are there any breast-feeding warnings?This drug may cause severe fetal defects. Do not breast-feed. Please consult your doctor.
Is it safe to drive while on this medicine?Caution is advised when driving or operating machinery.
Does this affect kidney function?No specific dosage adjustment is recommended. There is no clinical experience in the use of Dm Lef 10Mg Tablet in patients with renal impairment. The free fraction of MI is doubled in dialysis patients. Patients should be monitored closely for adverse effects requiring dosage adjustment.
Does this affect liver function?No specific dosage adjustment is recommended. Since the liver is involved in metabolic activation and subsequent metabolism/elimination of Dm Lef 10Mg Tablet, patients with hepatic impairment should be monitored closely for adverse effects requiring dosage adjustment.
What is the onset of action?The effect of this medicine is initiated within 2 hours after its administration.
How long is the duration of effect?The effect of this medicine will remain for about 12 - 14 hours.
Below is the list of medicines, which have the same composition, strength and form as Dm Lef 10Mg Tablet , and hence can be used as its substitute.
Are there any missed dose instructions?If you miss a dose of Dm Lef 10Mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Dm Lef 10Mg Tablet is a prodrug with anti-inflammatory and immunosuppressive properties that works by breaking down into its active metabolite A77 1726 once ingested which then blocks an important enzyme for de novo pyrimidine synthesis, dihydroorotate dehydrogenase. This inhibits the growth of activated T-lymphocytes.
Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.
Interaction with Medicine
Interaction with Disease
- Hepatic disease (including seropositive hepatitis B or C patients) may increase risk of hepatotoxicity; immunosuppression may increase the risk of lymphoproliferative disorders or other malignancies;
- Women of childbearing potential should not receive Dm Lef 10Mg Tablet until pregnancy has been excluded, patients have been counseled concerning fetal risk and reliable contraceptive measures have been confirmed.
- Caution in renal impairment.
- Not recommended for patients with severe immune deficiency, bone marrow dysplasia or uncontrolled infection.
- Has been associated with rare pancytopenia; use with caution in patients with a prior history of significant hematologic abnormalities.
- Discontinue if evidence of bone marrow suppression occurs, and begin procedure for accelerated removal (cholestyramine and activated charcoal).
- The use of live vaccines is not recommended.
- Dm Lef 10Mg Tablet will increase uric acid excretion.
Ques: What is Dm Lef 10Mg Tablet?
Ques: What is Dm Lef 10Mg Tablet used for?
Ques: How long do I need to use Dm Lef 10Mg Tablet before I see improvement in my condition?
Ques: At what frequency do I need to use Dm Lef 10Mg Tablet?
Ques: Should I use Dm Lef 10Mg Tablet empty stomach, before food or after food?
Ques: What are the instructions for the storage and disposal of Dm Lef 10Mg Tablet?
Ques: How long does Dm Lef 10Mg Tablet take to work?
Ques: What if I don't get better after using Dm Lef 10Mg Tablet?
Ques: Can Dm Lef 10Mg Tablet cause weight loss?
Ques: Can Dm Lef 10Mg Tablet cause cancer?
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