Choltran Oral Suspension, a bile acid sequestrant, is a strong ion exchange resin which binds bile within the alimentary canal and prevents its reabsorption. It forms insoluble complexes with bile acids and removes from them from the body during defecation. In order to compensate for the lost bile acids from the body, more plasma cholesterol gets converted to bile acids in the liver and hence reduces plasma cholesterol levels.
Choltran Oral Suspension is used to treat problems like hypercholesterolemia, pruritus (itching due to liver failure), post vagotomy diarrhoea, Clostridium difficile infections, post cholecystectomy syndrome, Crohn's disease, bile acid diarrhoea and other types of cholestasis. Choltran Oral Suspension is sometimes compounded with aquaphor and used for treating diaper rash in infants.
Choltran Oral Suspension is marketed as powder for oral ingestion, in 4g packets, or in larger containers and the dosage is 4 to 8g once twice daily. The maximum dosage is 24g per day.
Side effects of Choltran Oral Suspension include tarry stools, constipation, sudden loss in weight, stomach ache, bloating, belching, nausea, vomiting, indigestion, headache, dizziness, diarrhoea, femoral nerve pain, vertigo, muscle and joint pain, arthritis, osteoporosis, osteomalacia, urticaria (in cases of hypersensitivity), diuresis, hematuria, dysuria, asthma and others.