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In general, moderate exercise will not affect your creatinine levels. As you continue to exercise and build muscle mass, your creatinine levels may increase slightly but not to abnormal levels. ... Creatinine is a reflection of processes that are going on in your body and of kidney function. Thus, ?a bodybuilder with healthy kidneys might have an elevated creatinine level because of high muscle mass, whereas a frail elderly person might have normal or even low levels of creatinine, but in fact this person's kidneys are not working well ? it's just that there's not much creatinine because there's not much
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