I am suffering from constipation past 10.12 years, In these years, I tried various ways to get cured from homeopathy to acupuncture to Ayurveda, but none could give me the result, I finally started taking heavy dose of laxatives every day, I eventually got endoscopy and other tests are done, of which I got to know that my rectal sphincter muscles and brain nerves do not coordinate, hence while passing the motion, instead of the sphincter opening up it stays closed, with the advice of colorectal surgeon, I took few sessions of biofeedback exercises and anal physiotherapy, but it still did not help, I finally went for a botox injected at my rectum. Its been 6 months but there is still no change. What do I need to do, please help and guide me, as every doctor I go to is given me a different opinion, and I am really tired now.