I'm 71. Since nov 17, there is great abdomen discomfort at midnight. The contents in the column are stuck on left lower side, and cause great discomfort and adversely affect the mind so much that I have to constantly keep moving till the downward movement takes place in bowl and I pass gas. It continues whole night and I keep awake sometime till 4-5 am then I go to sleep for about 2 hrs. My colonoscopy, ct scan whole abdomen and UGI endoscopy are a normal study. My kft, lft ,and CBC tsh reports are ok. I am diagnosed as IBS -C. I have been on pegalup, please, lactifiber. Did not help. AIIMS advised Rifagut 550, lesuride, and lactifiber. No improvement in motility that keeps me awake at night. Then I have been on normaxin, and pan d.no improvement. I'm suffering this since nov 17 and have lost 7 kg since then. Laxatives do help for a day only. Some days I have to take enema. I do take high fiber diet, fruits and vegetables regularly. Will you please advise me how to get relief?