Usually when kidney gets affected one needs to find out the cause- whether it is due to diabetes
, kidney stone or drugs or any other cause. Detailed renal function with ultra sonography of abdomen and pelvis is recommended. Ophthalmic evaluation to rule out diabetic retinopathy
will be helpful in diagnosing whether renal involvement is because of uncontrolled diabetes or not. If kidney infection is the cause of increasing S. Creatinine then kidney friendly antibiotics have to be given as per culture reports. It is always safer and better to control blood sugars with insulin therapy as many anti diabetic drugs can not be continued when S. Creatinine is above 1.5 mg.