Metadrate Syrup is primarily used for symptomatic treatment of diabetic gastric stasis, gastroesophageal reflux; prevention of nausea associated with chemotherapy or postsurgery and facilitates intubation of the small intestine.
Metadrate Syrup is used in the treatment of diabetes, stomach and intestinal diseases. It increases the muscle contractions of the upper digestive tract. It provides relief in cases of heartburn and migraines. It prevents feelings of nausea and the tendency to vomit. Metadrate Syrup falls under the category of drugs known as dopamine-receptor antagonists.
The associated side-effects that come with the use of Metadrate Syrup are headache, dizziness, sleeping troubles, drowsiness and restlessness. Major side effects include depression, uncontrollable body movements, high fever, shakiness, skin rash, hives, rapid and irregular heartbeat and stiff muscles.
Avoid using Metadrate Syrup if; you have any allergies, you have bleeding or blockage in your intestines or stomach, you have epilepsy, seizure, kidney, liver or Parkinson’s diseases, you have high blood pressure, breast cancer or a history of depression.
Ideally the dosage for you will be prescribed by the doctor taking into consideration your specifications. Metadrate Syrup is available in both tablet and solution form. Usually the dosage prescribed is four times a day which needs to be taken before each meal and at night before sleeping.
Take this drug as prescribed, 30 minutes prior to eating. Do not increase dosage. Do not use alcohol or other CNS depressant or sleeping aids without consulting prescriber. May cause dizziness, drowsiness, or blurred vision.
Use caution when driving or engaging in tasks that require alertness until response to drug is known. May cause restlessness, anxiety, depression, or insomnia (will reverse when medication is discontinued). Report any CNS changes, involuntary movements, unresolved diarrhea. If diabetic, monitor serum glucose regularly.
Symptoms of overdose include drowsiness, ataxia, extrapyramidal reactions, seizures, methemoglobinemia (in infants); disorientation, muscle hypertonia, irritability, and agitation are common.
Metadrate Syrup often causes extrapyramidal symptoms (eg, dystonic reactions) requiring management with diphenhydramine 1-2 mg/kg (adults) up to a maximum of 50 mg I.M. or I.V. slow push followed by a maintenance dose for 48-72 hours. When these reactions are unresponsive to diphenhydramine, benztropine mesylate I.V. 1-2 mg (adults) may be effective. These agents are generally effective within 2-5 minutes.
Is It safe with alcohol?Metadrate Syrup may cause excessive drowsiness and calmness with alcohol.
Are there any pregnancy warnings?Metadrate Syrup is probably safe to use during pregnancy.
Animal studies have shown low or no adverse effect on the foetus, however, there are limited human studies. Please consult your doctor.
Are there any breast-feeding warnings?Metadrate Syrup is probably unsafe to use during breastfeeding. Please consult your doctor.
Is it safe to drive while on this medicine?Caution is advised when driving or operating machinery.
Does this affect kidney function?Caution to be advised in patients with impaired renal function.
Does this affect liver function?There is no data available. Please consult doctor before consuming the drug.
What is the onset of action?The effect of this drug will be initiated within 30 - 1 hour after its administration.
How long is the duration of effect?The effect of this drug remain effective for about 1 - 2 hours, regardless of the route of administration.
Are there any missed dose instructions?If you miss a dose of Metadrate Syrup, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
This medicine works by inhibiting gastric smooth muscle relaxation caused by dopamine. This improves the response of the gastrointestinal smooth muscles to cholinergic stimulation, which leads to an increase in gastric emptying into the intestines. It antagonises the dopamine D2 receptors in the medulla which prevents nausea and vomiting.
Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.
Interaction with Alcohol
Interaction with Lab Test
Interaction with Medicine
Interaction with Disease
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Metoclopramide-Drug Information Portal [Internet].druginfo.nlm.nih.gov 2022 [Cited 28 May 2022].Available from:https://druginfo.nlm.nih.gov/drugportal/name/metoclopramide
Metoclopramide-DrugBank Online [Internet].go.drugbank.com 2022 [Cited 28 May 2022].Available from:https://go.drugbank.com/drugs/DB01233
METOCLOPRAMIDE injection,solution-DailyMed [Internet].dailymed.nlm.nih.gov 2022 [Cited 28 May 2022].Available from:https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=METOCLOPRAMIDE
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