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Metadrate Syrup

Manufacturer: Lupin Ltd
Medicine composition: Metoclopramide, Magaldrate
Prescription vs.OTC: Prescription by Doctor required

Metadrate Syrup is primarily used for symptomatic treatment of diabetic gastric stasis, gastroesophageal reflux; prevention of nausea associated with chemotherapy or postsurgery and facilitates intubation of the small intestine.

Metadrate Syrup is used in the treatment of diabetes, stomach and intestinal diseases. It increases the muscle contractions of the upper digestive tract. It provides relief in cases of heartburn and migraines. It prevents feelings of nausea and the tendency to vomit. Metadrate Syrup falls under the category of drugs known as dopamine-receptor antagonists.

The associated side-effects that come with the use of Metadrate Syrup are headache, dizziness, sleeping troubles, drowsiness and restlessness. Major side effects include depression, uncontrollable body movements, high fever, shakiness, skin rash, hives, rapid and irregular heartbeat and stiff muscles.

Avoid using Metadrate Syrup if; you have any allergies, you have bleeding or blockage in your intestines or stomach, you have epilepsy, seizure, kidney, liver or Parkinson’s diseases, you have high blood pressure, breast cancer or a history of depression.

Ideally the dosage for you will be prescribed by the doctor taking into consideration your specifications. Metadrate Syrup is available in both tablet and solution form. Usually the dosage prescribed is four times a day which needs to be taken before each meal and at night before sleeping.

Take this drug as prescribed, 30 minutes prior to eating. Do not increase dosage. Do not use alcohol or other CNS depressant or sleeping aids without consulting prescriber. May cause dizziness, drowsiness, or blurred vision.

Use caution when driving or engaging in tasks that require alertness until response to drug is known. May cause restlessness, anxiety, depression, or insomnia (will reverse when medication is discontinued). Report any CNS changes, involuntary movements, unresolved diarrhea. If diabetic, monitor serum glucose regularly.

Symptoms of overdose include drowsiness, ataxia, extrapyramidal reactions, seizures, methemoglobinemia (in infants); disorientation, muscle hypertonia, irritability, and agitation are common.

Metadrate Syrup often causes extrapyramidal symptoms (eg, dystonic reactions) requiring management with diphenhydramine 1-2 mg/kg (adults) up to a maximum of 50 mg I.M. or I.V. slow push followed by a maintenance dose for 48-72 hours. When these reactions are unresponsive to diphenhydramine, benztropine mesylate I.V. 1-2 mg (adults) may be effective. These agents are generally effective within 2-5 minutes.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Gastroenterologist before using this medicine.

The most common use of this medication is:

Possible side effects of this tablet are as follows:

  • Is It safe with alcohol?

    Metadrate Syrup may cause excessive drowsiness and calmness with alcohol.
  • Are there any pregnancy warnings?

    Metadrate Syrup is probably safe to use during pregnancy.
    Animal studies have shown low or no adverse effect on the foetus, however, there are limited human studies. Please consult your doctor.
  • Are there any breast-feeding warnings?

    Metadrate Syrup is probably unsafe to use during breastfeeding. Please consult your doctor.
  • Is it safe to drive while on this medicine?

    Caution is advised when driving or operating machinery.
  • Does this affect kidney function?

    Caution to be advised in patients with impaired renal function.
  • Does this affect liver function?

    There is no data available. Please consult doctor before consuming the drug.
  • What is the onset of action?

    The effect of this drug will be initiated within 30 - 1 hour after its administration.
  • How long is the duration of effect?

    The effect of this drug remain effective for about 1 - 2 hours, regardless of the route of administration.
  • Are there any missed dose instructions?

    If you miss a dose of Metadrate Syrup, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

This medicine works by inhibiting gastric smooth muscle relaxation caused by dopamine. This improves the response of the gastrointestinal smooth muscles to cholinergic stimulation, which leads to an increase in gastric emptying into the intestines. It antagonises the dopamine D2 receptors in the medulla which prevents nausea and vomiting.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

  • Interaction with Alcohol

    Additive CNS effect, avoid use.
  • Interaction with Lab Test

    This drug might affect the results of aminotransferase [ALT (SGPT)/AST (SGOT)] (S), and amylase (S) if patient undergoes pathological test while taking this medicine.
  • Interaction with Medicine

    Increased toxicity: Opiate analgesics may increase CNS depression
  • Interaction with Disease

    Use with caution in patients with Parkinson's disease and in patients with a history of mental illness; dosage and/or frequency of administration should be modified in response to degree of renal impairment; extrapyramidal reactions, depression; may exacerbate seizures in seizure patients; to prevent extrapyramidal reactions, patients may be pretreated with diphenhydramine; elderly are more likely to develop dystonic reactions than younger adults; use lowest recommended doses initially.

Ques: What is Metadrate Syrup?

Ans: Metadrate Syrup is used in the treatment of diabetes, stomach and intestinal diseases. It increases the muscle contractions of the upper digestive tract. It provides relief in cases of heartburn and migraines.

Ques: What are the uses of Metadrate Syrup?

Ans: Metadrate Syrup acid used for the treatment of
  • Nausea
  • Vomiting
  • Heartburn

Ques: What are the side effects of this Metadrate Syrup?

Ans: The associated side-effects that come with the use of Metadrate Syrup are headache, dizziness, sleeping troubles, drowsiness and restlessness.

Ques: How long do I need to use Metadrate Syrup before I see improvement in my condition?

Ans: This medication is to be taken till the time you see an improvement in your health conditions.

Ques: At what frequency do I need to use Metadrate Syrup?

Ans: This medication should be taken in the dosage as prescribed by the doctor.

Ques: Should I use Metadrate Syrup empty stomach, before food or after food?

Ans: This medication should be taken after food in a prescribed dosage.

Ques: What are the instructions for the storage and disposal of Metadrate Syrup?

Ans: This medication should be kept in a cool dry place and in its original packaging. Make sure this medication remains unreachable to children and pets.

Ques: How is this Metadrate Syrup administered?

Ans: This medication is administered orally.
Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

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Content Details
Written By
PhD (Pharmacology) Pursuing, M.Pharma (Pharmacology), B.Pharma - Certificate in Nutrition and Child Care
Reviewed By
MBBS, Master in Healthcare Administration, Diploma in Occupational Health
General Physician
Table of Content
About Metadrate Syrup
What are the uses of Metadrate Syrup
What are the contraindications of Metadrate Syrup ?
What are the side effects of Metadrate Syrup ?
Key highlights of Metadrate Syrup
What are the dosage instructions?
How does this medication work?
What are the interactions of Metadrate Syrup ?
FAQs about Metadrate Syrup