Intalith Cr 450Mg Tablet

Manufacturer: Intas Pharmaceuticals Ltd
Medicine composition: Lithium
Prescription vs.OTC: Prescription by Doctor required
Last Updated: January 27, 2022

Intalith Cr 450Mg Tablet is an element that derives its name from the Greek word lithos meaning stone. It is used as a medicine most effectively in the treatment of bipolar disorder and other mental disorders such as poor cognitive skills, aggressive behavior, insomniac tendencies, hyperactivity.

It can also be used to treat epilepsy, diabetes, liver and kidney disease, arthritis, asthma, frequent headaches, eating disorders such as anorexia, bulimia and for blood disorders such as anemia.

On using Intalith Cr 450Mg Tablet you may experience certain side effects such as nausea, diarrhea, dizziness, fatigue, muscle weakness, mild tremors, frequent urge to urinate and thirst. These effects will decrease over time, however, if they should continue and worsen, seek medical aid right away.

Certain precautionary protocols that you are advised to follow before using Intalith Cr 450Mg Tablet includes notifying your doctor if you:

  • Are pregnant or are planning to become pregnant. Intalith Cr 450Mg Tablet can prove to be fatal for the fetus if used during pregnancy.
  • Are breastfeeding a baby. It can cause certain harmful side effects to the baby.
  • Have a history of heart disease, thyroid or kidney disease.
  • Are taking any prescriptive or over the counter drugs, herbal medications or dietary supplements.
  • Have recently had a surgery or are scheduled for one soon. Lithium usage should be discontinued two weeks before your surgery.

The dosage for Intalith Cr 450Mg Tablet will be determined by your doctor as per the seriousness of your condition, overall health, gender and age. Usually the prescribed dosage for adults diagnosed with manic or bipolar disorder is about 1800 mg per day.

It should be taken in three sets of about 600 mg each in the morning, afternoon and night. The dose for children 12 years or older is also the same. Patients are advised to seek the help of your health care provider should you suspect drug overdose, or symptoms of Brugada, encephalopathy, diabetes or insipidus.

Symptoms of overdose include sedation, confusion, tremors, joint pain, visual changes, seizures, coma. There is no specific antidote for lithium poisoning.

In the acute ingestion following initiation of essential overdose management, correction of fluid and electrolyte imbalances should be commenced. Hemodialysis and whole bowel irrigation is the treatment of choice for severe intoxications; charcoal is ineffective.

Take exactly as directed; do not change dosage without consulting prescriber. Do not crush or chew tablets or capsules. Maintain adequate fluid intake (2-3 L/day of fluids unless instructed to restrict fluid intake) especially in summer. Frequent blood test and monitoring will be necessary.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Psychiatrist before using this medicine.

The primary use of this medication is as follows:

  • Mania

    Intalith Cr 450Mg Tablet is used in the treatment of mania which is mood disorder characterized by hyperactivity, elevation in mood and extreme enthusiasm.
  • Bipolar Disorder

    Intalith Cr 450Mg Tablet is used in the treatment of bipolar disorder characterized by unusual shifts in the mood like hyperactivity and tiredness are some of the symptoms of bipolar disorder.
  • Allergy

    Not recommended in patients with known allergy to Intalith Cr 450Mg Tablet.
  • Severe Heart Disease

    Not recommended in patients with known heart diseases.

Following are some of the common side effects that may occur:

  • How long is the duration of effect?

    The effect of this medicine lasts for an average duration of 2 to 3 days.
  • What is the onset of action?

    The effect of this medicine can be observed in 5 to 7 days.
  • Are there any pregnancy warnings?

    This medicine is not recommended for pregnant women.
  • Is it habit forming?

    No habit forming tendency has been reported
  • Are there any breast-feeding warnings?

    This medicine is not recommended in breastfeeding women.
  • Does this affect kidney function?

    Caution must be taken in patients with kidney disease. Dosing adjustment in renal impairment:
    • Clcr 10-50 mL/minute: Administer 50% to 75% of normal dose.
    • Clcr <10 mL/minute: Administer 25% to 50% of normal dose.
    • Hemodialysis: Dialyzable (50% to 100%).
  • Does this affect liver function?

    Limited or no data available. Kindly consult your doctor before taking it.
  • Missed Dose instructions

    Take the missed dose as soon as you remember. If it’s almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.
  • Overdose instructions

    Seek emergency medical treatment or contact the doctor in case of an overdose.
  • India

  • United States

  • Japan

  • India

  • United States

  • Japan

Intalith Cr 450Mg Tablet is a mood-stabilising agent and although its exact way of working is unknown, it is believed to work by a number of ways including regulation of glutamate receptos, inhibition of the enzyme inositol monophosphatase or deactivation of the enzyme glycogen synthase kinase 3.

Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

  • Interaction with Alcohol

    Consumption of alcohol with this medicine is not recommended as it can result in dizziness and difficulty in concentration. Avoid activities that need mental alertness like driving and operating machinery.
  • Interaction with Lab Test

    This medicine might cause an increase in calcium (S), glucose, magnesium, potassium (S); and decrease in thyroxine (S) levels.
  • Interaction with Medicine

    • Concurrent use of lithium with carbamazepine, diltiazem, fluoxetine, fluvoxamine, haloperidol, methyldopa, phenothiazines, TCAs, and verapamil may increase the risk for neurotoxicity; monitor.
    • NSAIDs decrease renal lithium excretion leading to increased serum lithium concentrations; sulindac and aspirin may be the exceptions; monitor.
    • Combined use of lithium and chlorpromazine may lower serum concentrations of both drugs; monitor.
    • ACE inhibitors may increase the risk of lithium toxicity via sodium depletion; monitor.
    • Lithium and MAOIs should generally be avoided due to use reports of fatal malignant hyperpyrexia.
    • Losartan may reduce the renal clearance of lithium; monitor.
    • Phenytoin may enhance lithium toxicity; monitor.
    • Potassium iodide may enhance the hypothyroid effects of lithium; monitor.
    • Combined use of lithium with sibutramine may increase the risk of serotonin syndrome; this combination is best avoided.
    • Sodium bicarbonate and high sodium intake may reduce serum lithium concentrations via enhanced excretion; monitor.
    • Thiazide diuretics increase serum lithium concentration via sodium depletion.
  • Interaction with Disease

    Dementia

    This medicine is not recommended in patients with dementia-related psychosis as it increases the risk of heart diseases like heart failure and infectious diseases like pneumonia. An alternate medicine should be considered based on the clinical condition.

    Heart Diseases

    This medicine is not recommended in patients with heart disease. Inform the doctor if you have any heart disease before receiving this medicine. An alternate medicine should be considered based on the clinical condition.

    Hypothyroidism

    This medicine may alter the thyroid levels, therefore, not recommended in patients with hypothyroidism. Check the thyroid levels before starting the treatment. The treatment should be discontinued if thyroid levels are low.
  • Interaction with Food

    May be administered with meals to avoid GI upset; avoid changes in sodium content of diet; limit caffeine; food increases absorption; have patient drink 2-3 L of water daily; avoid changes in sodium content of diet (reduction in sodium intake can increase lithium toxicity), sodium is exchanged with lithium which may lead to elevated lithium levels; syrup may precipitate in tube feedings.

Ques: What is Intalith Cr 450Mg Tablet used for?

Ans: Intalith Cr 450Mg Tablet is used in the treatment of bipolar disorder and other mental disorders such as poor cognitive skills, aggressive behaviour, insomniac tendencies, hyperactivity.

Ques: Should Intalith Cr 450Mg Tablet be taken with a meal or without a meal?

Ans: The effectiveness of Intalith Cr 450Mg Tablet does not depend on a meal, it can be taken either way.

Ques: What is the onset of action of Intalith Cr 450Mg Tablet?

Ans: Intalith Cr 450Mg Tablet usually takes about 5 to 7 days to show its effect.

Ques: What is the duration of the effect of Intalith Cr 450Mg Tablet?

Ans: The effect of Intalith Cr 450Mg Tablet lasts between 2 to 3 days.

Ques: Is Intalith Cr 450Mg Tablet safe for usage in paediatrics?

Ans: Intalith Cr 450Mg Tablet is not recommended for usage in children below the age of 12 as its safety and effectiveness are not known.

Ques: Is Intalith Cr 450Mg Tablet safe for usage in geriatrics?

Ans: Intalith Cr 450Mg Tablet is not recommended for usage in geriatrics as it may build up in the body and induce Intalith Cr 450Mg Tablet side effects, along with its reaction with other medication.

Ques: How is Intalith Cr 450Mg Tablet administered?

Ans: Intalith Cr 450Mg Tablet is administered orally.
Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

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Content Details
Written By
PhD (Pharmacology) Pursuing, M.Pharma (Pharmacology), B.Pharma - Certificate in Nutrition and Child Care
Pharmacology
Reviewed By
MBBS, Master in Healthcare Administration, Diploma in Occupational Health
General Physician
Table of Content
About Intalith Cr 450Mg Tablet
What are the uses of Intalith Cr 450Mg Tablet
What are the contraindications of Intalith Cr 450Mg Tablet ?
What are the side effects of Intalith Cr 450Mg Tablet ?
Key highlights of Intalith Cr 450Mg Tablet
What are the dosage instructions?
Where is the Intalith Cr 450Mg Tablet approved?
How does this medication work?
What are the interactions of Intalith Cr 450Mg Tablet ?
FAQs about Intalith Cr 450Mg Tablet