The absence of an enzyme called cortisone reductase, results in a condition called ' Cortisone Reductase Deficiency'. It is a defect found in steroid metabolism caused by metabolic and genetic conditions. Most common symptoms are Enlarged adrenal glands, abdominal obesity, female infertility, premature puberty in males, accelerated bone age and acne in females. It is diagnosed by blood samples. However it cannot be cured.