Hello doctor, my wife is of 42 yrs, for quite long time approximately more then 8 years, she is suffering from urinary problem, at every intervals of 5 to 10 minutes, she has urge to go for discharging urine and this problem occurs in night hours also, due to this she cannot get good sleep and all her routine gets affected, she is working as a educator. We have done all pathological tests at every interval of six months but each time reports are coming normal. Further I need to inform you that she is allergic to paracetamol, sulpha, penicillin, metacin, stomach etc medicines. So there are limitations to take some kind of medicines. Please suggest any medication so she can concentrate on household and school work.