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The dose of hetrazan DEC does not reverse existing lymphatic damage and does not change the course of pathology in patients with established disease. Patients should be tested every 6-12 months for the presence of the parasite, and patients whose test results are positive should be re-treated. DEC is only partially effective against adult worms; therefore, ultrasonography of the scrotum should be performed 1 month after treatment; the presence of any residual worms is an indication for re-treatment. Recommended schedules are 6 mg/kg/d for a total of 72 mg/kg for Wuchereria bancrofti infection and 4 mg/kg/d for a total of 60 mg/kg for infection with Brugia malayi.
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