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Sodium Valproate

Prescription vs.OTC: Prescription by Doctor required
Last Updated: December 14, 2018

Sodium Valproate is a drug that aids in the control of seizures in patients who suffer from epilepsy. The drug is an anticonvulsant, and effectively increases a certain type of brain chemical that control some seizures. The drug may also be used to treat other conditions as per the doctor’s guidance.

Sodium Valproate is meant for oral consumption and can be taken before or with a meal. It is generally advised that the drug should not be taken with carbonated drinks, as irritation in the throat may occur. The dosage of the drug is primarily dependent on the patient’s age, health, weight and severity of the condition. In case you are taking Sodium Valproate to control seizures do not stop it suddenly. It is advised that the drug should be discontinued gradually, so as to prevent any complications.

Sodium Valproate use can lead to some side effects which include- dizziness, hair loss, tremor, diarrhea, changed in weight and blurred or double vision. These side effects stop gradually, but in case any of them continue or tend to worsen seek medical help immediately. A few patients may also experience mood swings and undergo depression resulting in suicidal thoughts. In this case family members should be well aware of such a side effect to take care of the patient. In case of over dosage of the drug seek immediate medical help. Symptoms of over dosage can include coma, irregular heart rate and extreme drowsiness.

In case of adults the doctor may prescribe a dosage ranging from 1000mg to 2000mg on a daily bases. Very low doses of Sodium Valproate are prescribed to children that may vary from 25mg to 30mg. An allergic reaction is very rare to this drug but may occur, resulting in a rash or chest pain along with shortness of breath. Seek medical help in this case.

Information given here is based on the salt and content of the medicine. Effect and uses of medicine may vary from person to person. It is advicable to consult a Neurologist before using this medicine.

Sodium Valproate is used in the treatment of Epilepsy which is a brain disorder that causes repeated seizures. Uncontrolled jerking movements and loss of consciousness are some of the symptoms of Epilepsy.
Sodium Valproate is used in the treatment of mania which is a mental disorder characterized by hyperactivity and racing thoughts.

Migraine Prophylaxis

Sodium Valproate is used as prophylaxis in migraine headaches characterized by severe headache, eye pain, nausea, and vomiting.
Do not take this medicine if you have a known allergy to Sodium Valproate.
Do not take if you have any liver injury or a family history of liver injury.

Urea cycle disorders

Do not use in patients with urea cycle disorder (high ammonium levels in the blood) or family history of urea cycle disorder.

Mitochondrial disorders

Do not use in patients and in children who are suspected to have the mitochondrial disorder (POLG e.g Alpers-Huttenlocher Syndrome).
In addition to its intended effect, Sodium Valproate may cause some unwanted effects too. In such cases, you must seek medical attention immediately. This is not an exhaustive list of side effects. Please inform your doctor if you experience any adverse reaction to the medication.

Nausea or Vomiting

Major Common

Diarrhea

Major Common

Shakiness in the legs, arms, hands, or feet

Major Common

Blurred vision

Major Less Common

Dizziness

Major Less Common

Weight gain

Major Less Common

Body pain

Minor Less Common

Skin rash

Minor Less Common

Sneezing

Minor Less Common

Dry or scaly skin

Minor Less Common

How long is the duration of effect?

The effect of this medicine lasts for an average duration of 24 hours.

What is the onset of action?

The peak effect of this medicine can be observed in 2 hours.

Are there any pregnancy warnings?

This medicine is not recommended for pregnant women.

Is it habit forming?

No habit forming tendency has been reported

Are there any breast-feeding warnings?

This medicine is recommended only if clearly needed when no safer alternative is available. Monitoring of undesired effects like discoloration of eyes and skin is necessary.

Missed Dose instructions

If you miss a dose of Sodium Valproate, take the missed dose as soon as you remember. If it’s almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.

Overdose instructions

Seek emergency medical treatment or contact the doctor in case of an overdose.

India

United States

Japan

Below is the list of medicines, which contains Sodium Valproate as ingredient
Abbott India Ltd
Linux Laboratories
Sanofi India Ltd
Sanofi India Ltd
Sanofi India Ltd
Sanofi India Ltd
Intas Pharmaceuticals Ltd
Sun Pharmaceutical Industries Ltd
Talent India
Kivi Labs Ltd
Sun Pharma Laboratories Ltd
Ipca Laboratories Pvt Ltd.
Micro Labs Ltd
Intas Pharmaceuticals Ltd
Sun Pharma Laboratories Ltd
Arinna Lifesciences Pvt. Ltd
Abbott India Ltd
Torrent Pharmaceuticals Ltd
Sun Pharma Laboratories Ltd
Sodium Valproate belongs to the class anticonvulsants. it works by increasing the levels of neurotransmitter GABA and inhibits sodium and calcium channels thus it reduces the excitation of the brain cells.
Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.

Interaction with Disease

Depression

Major
Sodium Valproate should be given with caution in the patients with depression and suicidal thoughts. Frequent monitoring of depression symptoms is necessary. Dose adjustments are to be made based on the outcomes in the patient.

Liver Disease

Major
Sodium Valproate is not recommended in patients with liver injury or a family history of liver injury. This risk is more in children less than 2 years of age. Liver function tests are to be performed before starting the treatment. Discontinue the medicine if any abnormality is identified.

Interaction with Alcohol

Alcohol

Moderate
Consumption of alcohol with this medicine is not recommended as it increases the risk of side effects like dizziness, difficulty in concentration. Do not perform activities that require mental alertness like driving or operating machinery.

Interaction with Lab Test

Lab

Information not available.

Interaction with Food

Food

Information not available.

Interaction with Medicine

Lamotrigine

Major
Sodium Valproate may increase the concentration of lamotrigine and can cause serious skin reactions. Frequent monitoring of undesired effects like skin rash, seizures, tremors is necessary. Suitable dose adjustments or an alternate medicine should be considered based under the doctor's supervision.

Metoclopramide

Moderate
Use of Sodium Valproate with metoclopramide should be avoided if possible. Do not operate heavy machinery if you are using these medicines. Suitable dose adjustments or an alternate medicine should be considered based on the clinical condition under the doctor's supervision.

Warfarin

Moderate
Sodium Valproate should be given with caution in patients with warfarin or other anticoagulants as this combination may increase the risk of bleeding. Frequent monitoring of blood cells count and prothrombin time is necessary. Suitable dose adjustments or an alternate medicine should be considered based on the clinical condition under the doctor's supervision.

Ethinyl Estradiol

Moderate
The desired effect of Sodium Valproate will not be observed if taken with oral contraceptives. Inform the doctor if you are receiving either of the medications. Monitoring of behavior changes and seizures are necessary. An alternate medicine should be considered based on the clinical condition of the under the doctor's supervision.

Imipenem

Major
Use of these medicines is not recommended as it increases the concentration of Sodium Valproate. An alternate medicine should be considered based on the clinical condition under the doctor's supervision.
Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

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Table of Content
About Sodium Valproate
What are the uses of Sodium Valproate
What are the contraindications of Sodium Valproate ?
What are the side effects of Sodium Valproate ?
Key highlights of Sodium Valproate
What are the dosage instructions?
Where is the Sodium Valproate approved?
Medicines containing Sodium Valproate
How does medicine works?
What are the interactions of Sodium Valproate ?