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Overview

Epival Syrup

Manufacturer: Sun Pharmaceutical Industries Ltd
Medicine composition: Sodium Valproate
Prescription vs.OTC: Prescription by Doctor required

Epival Syrup is a drug that aids in the control of seizures in patients who suffer from epilepsy. The drug is an anticonvulsant, and effectively increases a certain type of brain chemical that control some seizures. The drug may also be used to treat other conditions as per the doctor’s guidance.

Epival Syrup is meant for oral consumption and can be taken before or with a meal. It is generally advised that the drug should not be taken with carbonated drinks, as irritation in the throat may occur. The dosage of the drug is primarily dependent on the patient’s age, health, weight and severity of the condition. In case you are taking Epival Syrup to control seizures do not stop it suddenly. It is advised that the drug should be discontinued gradually, so as to prevent any complications.

Epival Syrup use can lead to some side effects which include- dizziness, hair loss, tremor, diarrhea, changed in weight and blurred or double vision. These side effects stop gradually, but in case any of them continue or tend to worsen seek medical help immediately. A few patients may also experience mood swings and undergo depression resulting in suicidal thoughts. In this case family members should be well aware of such a side effect to take care of the patient. In case of over dosage of the drug seek immediate medical help. Symptoms of over dosage can include coma, irregular heart rate and extreme drowsiness.

In case of adults the doctor may prescribe a dosage ranging from 1000mg to 2000mg on a daily bases. Very low doses of Epival Syrup are prescribed to children that may vary from 25mg to 30mg. An allergic reaction is very rare to this drug but may occur, resulting in a rash or chest pain along with shortness of breath. Seek medical help in this case.

Epival Syrup is used in the treatment of Epilepsy which is a brain disorder that causes repeated seizures. Uncontrolled jerking movements and loss of consciousness are some of the symptoms of Epilepsy.
Epival Syrup is used in the treatment of mania which is a mental disorder characterized by hyperactivity and racing thoughts.
Migraine Prophylaxis
Epival Syrup is used as prophylaxis in migraine headaches characterized by severe headache, eye pain, nausea, and vomiting.
Do not take this medicine if you have a known allergy to Epival Syrup.
Do not take if you have any liver injury or a family history of liver injury.
Urea cycle disorders
Do not use in patients with urea cycle disorder (high ammonium levels in the blood) or family history of urea cycle disorder.
Mitochondrial disorders
Do not use in patients and in children who are suspected to have the mitochondrial disorder (POLG e.g Alpers-Huttenlocher Syndrome).
In addition to its intended effect, Epival Syrup may cause some unwanted effects too. In such cases, you must seek medical attention immediately. This is not an exhaustive list of side effects. Please inform your doctor if you experience any adverse reaction to the medication.
Nausea or Vomiting Major Common
Diarrhea Major Common
Shakiness in the legs, arms, hands, or feet Major Common
Blurred vision Major Less Common
Dizziness Major Less Common
Weight gain Major Less Common
Body pain Minor Less Common
Skin rash Minor Less Common
Sneezing Minor Less Common
Dry or scaly skin Minor Less Common
How long is the duration of effect?
The effect of this medicine lasts for an average duration of 24 hours.
What is the onset of action?
The peak effect of this medicine can be observed in 2 hours.
Are there any pregnancy warnings?
This medicine is not recommended for pregnant women.
Is it habit forming?
No habit forming tendency has been reported
Are there any breast-feeding warnings?
This medicine is recommended only if clearly needed when no safer alternative is available. Monitoring of undesired effects like discoloration of eyes and skin is necessary.
Below is the list of medicines, which have the same composition, strength and form as Epival Syrup, and hence can be used as its substitute.
Intas Pharmaceuticals Ltd
Sun Pharmaceutical Industries Ltd
Ipca Laboratories Ltd
Sun Pharmaceutical Industries Ltd
Abbott India Ltd
Mankind Pharma Ltd
Micro Labs Ltd
Alkem Laboratories Ltd
Shine Pharmaceuticals Ltd
Missed Dose instructions
If you miss a dose of Epival Syrup, take the missed dose as soon as you remember. If it’s almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.
Overdose instructions
Seek emergency medical treatment or contact the doctor in case of an overdose.
India
United States
Japan
Whenever you take more than one medicine, or mix it with certain foods or beverages, you're at risk of a drug interaction.
Interaction with Disease
Depression Major
Epival Syrup should be given with caution in the patients with depression and suicidal thoughts. Frequent monitoring of depression symptoms is necessary. Dose adjustments are to be made based on the outcomes in the patient.
Liver Disease Major
Epival Syrup is not recommended in patients with liver injury or a family history of liver injury. This risk is more in children less than 2 years of age. Liver function tests are to be performed before starting the treatment. Discontinue the medicine if any abnormality is identified.
Interaction with Alcohol
Alcohol Moderate
Consumption of alcohol with this medicine is not recommended as it increases the risk of side effects like dizziness, difficulty in concentration. Do not perform activities that require mental alertness like driving or operating machinery.
Interaction with Lab Test
Lab
Information not available.
Interaction with Food
Food
Information not available.
Interaction with Medicine
Lamotrigine Major
Epival Syrup may increase the concentration of lamotrigine and can cause serious skin reactions. Frequent monitoring of undesired effects like skin rash, seizures, tremors is necessary. Suitable dose adjustments or an alternate medicine should be considered based under the doctor's supervision.
Metoclopramide Moderate
Use of Epival Syrup with metoclopramide should be avoided if possible. Do not operate heavy machinery if you are using these medicines. Suitable dose adjustments or an alternate medicine should be considered based on the clinical condition under the doctor's supervision.
Warfarin Moderate
Epival Syrup should be given with caution in patients with warfarin or other anticoagulants as this combination may increase the risk of bleeding. Frequent monitoring of blood cells count and prothrombin time is necessary. Suitable dose adjustments or an alternate medicine should be considered based on the clinical condition under the doctor's supervision.
Ethinyl Estradiol Moderate
The desired effect of Epival Syrup will not be observed if taken with oral contraceptives. Inform the doctor if you are receiving either of the medications. Monitoring of behavior changes and seizures are necessary. An alternate medicine should be considered based on the clinical condition of the under the doctor's supervision.
Imipenem Major
Use of these medicines is not recommended as it increases the concentration of Epival Syrup. An alternate medicine should be considered based on the clinical condition under the doctor's supervision.
What are you using Epival Syrup for?
Epilepsy
Other
Mania
How much was the improvement?
Excellent
Average
Poor
How long did it take before seeing improvement?
More than 2 days
Within a day
Within 2 hours
Within 2 days
Within 6 hours
How frequently did you take this medicine?
Twice a day
Once a day
Not taking on daily level
Thrice a day
Four times A Day
How did you take this medicine?
With Food
With or without food
Empty stomach
What were the side effects of this medicine?
Dizziness
arms
No Side Effects
or feet
Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.

Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is no mention of a warning for any drug or combination, it never means that we are claiming that the drug or combination is safe for consumption without any proper consultation with an expert.

Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.

Popular Questions & Answers

I am facing a erectile dysfunction from last one year I am taking EPIVAL 500 AMNSTAN 10/160 NISE 100 MG I am high blood pressure patient and having epilepsy problem please resolve my issue and prescribe medicine for ED.

BHMS
Homeopath, Murshidabad
I am facing a erectile dysfunction from last one year
I am taking EPIVAL 500
AMNSTAN 10/160
NISE 100 MG
I am high blo...
Dear Lybrate User, Kindly note that if you indulge in sexual relation after an interval of minimum 7 days then you are bound to discharge quickly during intercourse but that does not imply that you have any disease. It occurs due to loss of control of the muscles of penis. Normally it is seen that when a person does sexual intercourse daily he gains control over the muscles of penis & can stay longer during sex. You need to take Homoeopathic Mother Tincture TITANIUM 200, 5 drops, thrice daily, in empty stomach to get rid of Premature Ejaculation. But before taking any medicine kindly notice whether you are having a second erection within 15 minutes of ejaculation for the first time. If you are not experiencing any erection within 15 minutes of ejaculation then you are surely suffering from ERECTILE DYSFUNCTION. There will be a change of medication in this case. To get rid of Erectile Dysfunction you need to take Homoeopathic Mother Tincture DAMIANA Q, 30 drops, thrice daily, after meals, in a cup of water. Kindly note that this medication may not be sufficient enough to take care of your problem. These medicines are based on the symptoms of your diseased condition & these medicines need to be complemented by further deep-acting remedies in order to permanently eliminate the underlying cause of the disease. So I would suggest you to consult me privately via Lybrate as it is very necessary to diagnose the proper underlying cause of your problem if you are wishing for a permanent relief from your problems. A permanent annihilation of the underlying cause of the disease will not only provide you relief from your troubles but it will also cease any chance of further relapse of that particular disease condition. You can consult me privately.

My baby is 3.6 years but she is born this time the doctor saw her head is some small he tell me everything is fine no problem. But next two years suddenly I have look him she is mrigi patient I have consult doctor then I have two time brain mri and one time (what is the marks test? I loose my memories) the marks test is abnormal then I am treating now syrup EPIVAL consulted by doctor. But baby not speaking properly sentence by sentence and which time of this disease for end please

MRCPCH (London), DNB Paediatrics
Pediatrician, Mumbai
Hi Mr. lybrate-user. I hope you want to say Mirgi ki bimaari matlab Convulsions. Your baby has small head size and convulsions. Also baby is recieving Epival which is a good anti epileptic drug. Your baby also underwent MRI brain twice. This all suggests that she has some organic and functional problems which is not good for me to guess without examining your child and going through all the investigation reports. So it is not possible to comment on prognosis of the disease. Children of 3.5 year old are not fluent in speaking also they do make a sentence of 2-3 words only. Many times only parents can understand what child wants to speak. Your baby has some issues and she is on medication hence we don't expect her to outperform in speaking. If she understands your spoken language and follows commands also if she is able to ask for things she wants then there won't be any difficulty for her to catch up speaking in near future. Speak to your paediatrician when you consult him next time.
1 person found this helpful

Hi! Doctor has prescribed me Valproate ER tab. But as it is not available in market can I take Valproate CR instead? And suppose if i'm taking Valproate CR is there any side effects? What to do? Please advice.

MBBS
General Physician, Mumbai
It’s better to take valproate ER as per prescription but for a day if necessary there is no harm in taking valproate CR
1 person found this helpful

Sir, please tell me uses of VALISTAB CR 300 tablet .It contains Sodium Valproate and Valproic acid.

BHMS
Homeopath, Hooghly
Sir, please tell me uses of VALISTAB CR 300 tablet .It contains Sodium Valproate and Valproic acid.
It is usually been given to control epilepsy,bipolar disorder,to prevent pain of migraine,,in seizures absence seizures,partial seizures, generalized seizures also
1 person found this helpful

Hi, I took sodium valproate for one and half years till last May. Then I stopped and am taking oleptal OD. Am I have a chance of getting valproate 's side effect POLYCYSTIC OVARIAN DISEASE?

MD - Homeopathy, BHMS
Homeopath, Vadodara
Hi, I took sodium valproate for one and half years till last May. Then I stopped and am taking oleptal OD. Am I have ...
Pcod is not just because of sodium valproate.. And yes you can develop it.. It is very common in women now.

Popular Health Tips

Managing EPILEPSY in WOMEN

MBBS, MD - General Medicine, DM - Neurology
Neurologist, Hyderabad
Managing EPILEPSY in WOMEN

Epilepsy is a common illness and therefore, we commonly encounter women with epilepsy (WWE), who are either pregnant or contemplating pregnancy. There are a lot of apprehensions and misconceptions regarding managing epilepsy in this group of WWE. Here, I wish to highlight some of the important aspects of managing epilepsy in women who are planning a pregnancy or are currently pregnant.

1. If a woman is seizure-free for at least two years, she can consider withdrawing anti-epileptic drugs (aeds) under the supervision of neurologist, and then plan for pregnancy.

2. If a woman has seizures, it is better to continue aeds during pregnancy, as the risk to the baby is several times higher with seizures, as compared to that with aeds.

3. Sodium valproate has the highest risk to the developing baby, and it should be avoided in pregnancy.

4. Aeds such as levetiracetam, lamotrigine, oxcarbazepine, topiramate, etc are safe and may be continued during pregnancy.

5. The lowest effective dose of aed should be used.

6. Try to use only a single anti-epileptic drug, if possible.

7. Folic acid vitamin supplements should be used in pregnancy.

8. The dose of anti-epileptic medication may have to be increased during the last three months of pregnancy.

9. Ct scan of the brain should be avoided, as far as possible, during pregnancy, as radiation exposure due to it may harm the baby.

10. Mri brain is reasonably safe for baby, especially after the first three months of pregnancy. So, if needed, it may be performed.


 

9 people found this helpful

3 Symptoms Of Bipolar disorder And Its Treatment!

MD - Psychiatry
Psychiatrist, Ahmedabad
3 Symptoms Of Bipolar disorder And Its Treatment!

Bipolar disorder is also known as maniac depression. This usually sets in low and high moods in a person along with change in energy and sleep.
People with bipolar disorder tend to have periodical changes; sometimes they are over happy and other times they might feel sad, depressed and hopeless. Between these changes they are normal. The highs and lows are considered as extreme poles of moods, thus the name bipolar disorder.

Manic term is used when a person with bipolar disorder is highly excited and feels confident. Also, feelings of irritability and recklessness along with irrationality might occur. Some people with mania might have a hallucination that is they see and hear things that are not there, along with delusions. 

The term hypomania is used to describe mild symptoms of mania, in which a person does not have hallucinations and delusions and the symptoms do not interfere with their daily life. Similarly, the term depressive is used to describe a person's time when they feel depressed or sad. 

Symptoms of Bipolar Disorder

  • The highs and lows in a bipolar disorder do not follow any set pattern. One might feel manic or depressed for hours or days or weeks, months and even years together before they actually switch to a happy mood. The severity depends from person to person and also changes with time by becoming less or more severe.
  • Symptoms of mania or the high are extreme excitement, change from being happy to angry and irritable along with restlessness, speech is rapid with low concentration, less sleep and increased energy, high se drive, grand plans, alcohol and drug abuse and impulsiveness.
  • Symptoms of low or depressive phase are lethargy, worthlessness, feeling of sadness and hopelessness, lowered concentration, irritability, loss of sleep or excessive sleeping, loss of appetite and suicidal tendencies.

Diagnosis of Bipolar Disorder:
In case someone exhibits symptoms of bipolar disorder, then talking to a psychiatrist or a doctor helps. Doctors ask questions related to the mental illness and the associated concerns. Diagnosis is basically recognizing the symptoms of the person, whether they are due to some underlying cause or mood swings because of excessive alcohol. The symptoms have to be noted and the duration for which they last along with the severity should all be noted. The most obvious symptoms are that of lows and highs in mood and changes in behavior, energy, sleep and thoughts.

Consulting a doctor or talking to family and friends helps to differentiate the symptoms of bipolar disorder from unipolar disorder.

Treatment:
Medicines which involve mood stabilizers such as lamotrigine, valproate, lithium, carbamazepine and antipsychotics such as olanzapine, quetiapine should be taken. Psychotherapy is also recommended.

Seizures - How To Get Rid of It?

MS - General Surgery, MCh - Neuro Surgery, MBBS
Neurosurgeon, Greater Noida
Seizures - How To Get Rid of It?

The primary aim of the treatment in patients suffering from seizure is leasing a seizure-free life without giving way to any adverse effects. This goal can be accomplished in over 60 percent people with the help of anticonvulsants. Some patients also experience adverse effects since they suffer from a seizure which is refractory to medical therapy. Here are some of the common treatment options for seizures:

  1. Monotherapy: Sometimes, monotherapy is given as it reduces the chance of all sorts of adverse effects and even avoids drug interactions. Moreover, this type of treatment approach is much less expensive than polytherapy since many older generation of the anticonvulsant agent comprises of hepatic enzyme which is responsible for reducing the serum level of the concomitant drug which leads to an increase in the dosage level of such medicines.
  2. Social And vocational rehabilitation: People suffering from problems in psychosocial adjustments after the diagnosis may also need social and vocational rehabilitation. Many physicians do not pay enough attention to the consequences that an epilepsy diagnosis may leave on the patient. For instance, people with epilepsy may have a fear of experiencing next attack of seizure and they may be unable to work at heights or drive.
  3. Consulting an expert: It is important to refer patients with intractable spells to epileptologist or neurologist for subsequent workup. A neurosurgical consultation may also be needed when the patient has to be treated surgically.

Importance of anticonvulsant therapy
Patients who have had already suffered from recurrent attacks of unprovoked seizure may need treatment with an anticonvulsant. This treatment is not recommended until the person has risk factors for suffering from the problem yet again. The primary means of treating seizure is anticonvulsant therapy where the most suitable drug is chosen based on accurate diagnosis of the syndrome as a response to specific anticonvulsants may vary from one patient to another. The difference in response may reflect the various pathophysiologic mechanisms in different types of seizures.

Types of anticonvulsant therapy
Some of the anticonvulsant therapy medication may have multiple action mechanism while some have an only single mechanism of action. Some of the most common variants of the therapy include:

  1. Neuronal potassium channel referred to as KCNQ opener
  2. Blockers of unique binding sites such as perampanel, gabapentin, and levetiracetam
  3. H-current modulators such as lamotrigine and gabapentin
  4. Carbonic anhydrase inhibitors such as zonisamide and topiramate
  5. Alpha-amino 3-hydroxy 5-methyl 4-isoxazole propionic acid receptor blockers like topiramate and perampanel.
  6. N and L-calcium channel blockers like zonisamide, valproate, topiramate, and lamotrigine

Even though there are so many types of drugs available, all of them cannot be used for the treatment of seizures. Doctors would evaluate the condition thoroughly before prescribing a medication that can be helpful in reducing the severity of the condition. In case you have a concern or query you can always consult an expert & get answers to your questions!

2540 people found this helpful

Seizures - 3 Ways It Can Be Treated!

MCh - Neurosurgery, MS-General Surgery, MBBS
Neurosurgeon, Delhi
Seizures - 3 Ways It Can Be Treated!

The primary aim of the treatment in patients suffering from seizure is leasing a seizure-free life without giving way to any adverse effects. This goal can be accomplished in over 60 percent people with the help of anticonvulsants. Some patients also experience adverse effects since they suffer from a seizure which is refractory to medical therapy. Here are some of the common treatment options for seizures:

  1. Monotherapy: Sometimes, monotherapy is given as it reduces the chance of all sorts of adverse effects and even avoids drug interactions. Moreover, this type of treatment approach is much less expensive than polytherapy since many older generation of the anticonvulsant agent comprises of hepatic enzyme which is responsible for reducing the serum level of the concomitant drug which leads to an increase in the dosage level of such medicines.
  2. Social And vocational rehabilitation: People suffering from problems in psychosocial adjustments after the diagnosis may also need social and vocational rehabilitation. Many physicians do not pay enough attention to the consequences that an epilepsy diagnosis may leave on the patient. For instance, people with epilepsy may have a fear of experiencing next attack of seizure and they may be unable to work at heights or drive.
  3. Consulting an expert: It is important to refer patients with intractable spells to epileptologist or neurologist for subsequent workup. A neurosurgical consultation may also be needed when the patient has to be treated surgically.

Importance of anticonvulsant therapy

Patients who have had already suffered from recurrent attacks of unprovoked seizure may need treatment with an anticonvulsant. This treatment is not recommended until the person has risk factors for suffering from the problem yet again. The primary means of treating seizure is anticonvulsant therapy where the most suitable drug is chosen based on accurate diagnosis of the syndrome as a response to specific anticonvulsants may vary from one patient to another. The difference in response may reflect the various pathophysiologic mechanisms in different types of seizures.

Types of anticonvulsant therapy
Some of the anticonvulsant therapy medication may have multiple action mechanism while some have an only single mechanism of action. Some of the most common variants of the therapy include:

  1. Neuronal potassium channel referred to as KCNQ opener
  2. Blockers of unique binding sites such as perampanel, gabapentin, and levetiracetam
  3. H-current modulators such as lamotrigine and gabapentin
  4. Carbonic anhydrase inhibitors such as zonisamide and topiramate
  5. Alpha-amino 3-hydroxy 5-methyl 4-isoxazole propionic acid receptor blockers like topiramate and perampanel.
  6. N and L-calcium channel blockers like zonisamide, valproate, topiramate, and lamotrigine

Even though there are so many types of drugs available, all of them cannot be used for the treatment of seizures. Doctors would evaluate the condition thoroughly before prescribing a medication that can be helpful in reducing the severity of the condition.

In case you have a concern or query you can always consult an expert & get answers to your questions!

2734 people found this helpful

Bipolar Disorder - Symptoms And Diagnosis

MS - Counselling and Psychotherapy, Diploma in Psychological Medicine , MBBS
Psychiatrist, Bangalore
Bipolar Disorder - Symptoms And Diagnosis

Bipolar disorder is also known as manic depression. This usually sets in low and high moods in a person along with changes in energy and sleep.

People with bipolar disorder tend to have periodical changes; sometimes they are over happy and other times they might feel sad, depressed and hopeless. Between these changes they are normal. The highs and lows are considered as extreme poles of moods, thus the name bipolar disorder.

Manic term is used when a person with bipolar disorder is highly excited and feels confident. Also, feelings of irritability and recklessness along with irrationality might occur. Some people with mania might have a hallucinations that is they see and hear things that are not there, along with delusions.

The term hypomania is used to describe mild symptoms of mania, in which a person does not have hallucinations and delusions and the symptoms do not interfere with their daily life. Similarly, the term depressive is used to describe a person's time when they feel depressed or sad.

Symptoms of Bipolar Disorder

  • The highs and lows in a bipolar disorder do not follow any set pattern. One might feel manic or depressed for hours or days or weeks, months and even years together, before they actually switch to a happy mood. The severity depends from person to person and also changes with time by becoming less or more severe.
  • Symptoms of mania or the high are extreme excitement, change from being happy to angry and irritable along with restlessness, speech is rapid with low concentration, less sleep and increased energy, grand plans, alcohol and drug abuse and impulsiveness.
  • Symptoms of low or depressive phase are lethargy, worthlessness, feeling of sadness and hopelessness, lowered concentration, irritability, loss of sleep or excessive sleeping, loss of appetite and suicidal tendencies.

Diagnosis of Bipolar Disorder

  • In case someone exhibits symptoms of bipolar disorder, then talking to a psychiatrist or a doctor helps. Doctors ask questions related to the mental illness and the associated concerns. Diagnosis is basically recognizing the symptoms of the person, whether they are due to some underlying cause or mood swings because of excessive alcohol. The symptoms have to be noted and the duration, for which they last along with the severity should all be noted. The most obvious symptoms are that of lows and highs in mood and changes in behavior, energy, sleep and thoughts.
  • Consulting a doctor or talking to family and friends helps to differentiate the symptoms of bipolar disorder from unipolar disorder.

Treatment

3750 people found this helpful

Table of Content

About Epival Syrup
When is Epival Syrup prescribed?
What are the contraindications of Epival Syrup?
What are the side effects of Epival Syrup?
Key highlights of Epival Syrup
What are the substitutes for Epival Syrup?
What are the dosage instructions?
Where is the Epival Syrup approved?
What are the interactions for Epival Syrup?