Ondansetron belongs to the antiemetics drug group that is used for treating nausea as well as vomiting, caused by other medical treatments such as surgery, chemotherapy and radiation. This medicine will block the chemical serotonin from releasing in your gut and your central nervous system. This will prevent vomiting and nausea. Ondansetron is available in four different forms that can be taken orally; tablet, disintegrating (dissolving) tablet, solution and film. It also comes in an IV (intravenous) form that can be injected to your body by a doctor. You can take it with food or without food.
Ondansetron can be used alone as well as in a combination with other medicines for preventing vomiting and nausea that one experiences after a surgery, chemotherapy or radiation session. This medicine, belonging to the drug group named antiemetics, blocks serotonin, a natural substance present in the body that is known to cause vomiting. Ondansetron is available both in tablet and liquid form. You can also take it in the IV form, when injected by a medical practitioner.
Your doctor must be informed if you are allergic to Ondansetron as well as other medications that block serotonin, along with any other allergies that you have. He/ She must also know about your medical history and if you had problems such as liver disease, irregular heartbeat and stomach or intestinal problems in the past. Apart from that, you must also inform the doctor if you are under any medication for depression or any psychiatric disorder.
The dosage of Ondansetron is decided after taking your medical condition into account and how responsive your body is to therapy. In case of children, the dose also depends on their weight and age. If you are undergoing chemotherapy, you need to take Ondansetron orally half an hour before your treatment starts. In case of radiation, take it 1-2 hours before the procedure of treatment begins. For preventing nausea before a surgery, it is advised to take the medication an hour before your surgery. In case you miss a dose, you can take the medication once you remember it. If it is already time for the next dose, ensure that you do not take two doses to make up for the missed dose. Overdose of Ondansetron can lead to severe constipation, faint spells or feeling light-headed.
The side effects of Ondansetron can include dizziness, drowsiness, diarrhea, constipation and headache. These side effects are usually mild in nature and goes away in a few days or 1-2 weeks. You can consult your doctor if these symptoms remain for a long time. There are some serious side effects that Ondansetron may have, which would require immediate medical supervision. They include:
- Stiffness of the muscle / muscle spasms
- Blurred vision or loss of vision temporarily
- Fast heartbeat and sweating
- Headache, accompanied with chest pain and a feeling of dizziness
- Yellowing of the eyes or the skin
- An allergic reaction to the medication; the symptoms of which include fever, chills, rashes, difficulty in breathing and swelling of the lips, tongue, throat or face.
Information given here is based on the salt and content of the medicine. Effect and uses of medicine may vary from person to person. It is advicable to consult a Internal Medicine Specialist before using this medicine.
ApomorphineAvoid using Ondansetron with Ondansetron as it increases the risk of lightheadedness and loss of consciousness.
How long is the duration of effect?This medicine is excreted primarily in urine and the effect of this medicine lasts for a duration of 12 to 28 hours.
What is the onset of action?The peak effect of Ondansetron can be observed within 30 minutes for Intravenous and 2 hours for the tablet.
Are there any pregnancy warnings?Use of Ondansetron is not recommended in pregnant women.
Is it habit forming?No habit forming tendency has been reported.
Are there any breast-feeding warnings?No clear data is available whether Ondansetron is excreted through human breast milk. So, use of this drug is not recommended in breastfeeding women.
Are there any overdose instructions?Seek emergency medical attention or contact the doctor in case of overdose.
Below is the list of medicines, which contains Ondansetron as ingredient
Ondansetron works by blocking 5-HT3 receptors peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone.
Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction.
Interaction with Disease
Qt ProlongationDetails of any heart disease, family history of an arrhythmia or any other drugs that cause QT interval prolongation (eg: Antipsychotics, Arrhythmia drugs) should be reported to the doctor. Regular cardiac function tests are to be performed if the patient is having any heart disease. jaundice, hepatitis) or other drugs that may affect the liver (eg: TB drugs, HIV drugs) should be reported to the doctor. Regular liver function tests are to be performed if the patient is having any liver disease.
Interaction with Alcohol
AlcoholInteraction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Lab Test
LabInformation not available.
Interaction with Food
FoodInformation not available.
Interaction with Medicine
ApomorphineUse of Ondansetron with Apomorphine is not recommended. Replacement of the drug should be considered under the doctor's supervision. Usage of other medicines should be reported to the doctor.
AmiodaroneUse of Ondansetron with Amiodarone is not recommended as it may cause dizziness, lightheadedness, difficulty in breathing if these drugs are used together. Regular cardiac function tests are to be performed if the patient is having any heart disease. Under doctor's supervision, appropriate dose adjustments or replacement of the drug should be considered. Usage of other medicines should be reported to the doctor.
AmitriptylineIf these drugs are used together, the patient may experience confusion, hallucination, changes in blood pressure, fever or excessive sweating. Under doctor's supervision, appropriate dose adjustments or replacement of the drug should be considered. Usage of other medicines should be reported to the doctor.
CarbamazepinePatient's nausea and vomiting may not subside if these drugs are taken together. Under doctor's supervision, appropriate dose adjustments or replacement of the drug should be considered. Details of other drugs should be reported to the doctor.
PhenytoinPatient's nausea and vomiting may not subside if these drugs are taken together. Under doctor's supervision, appropriate dose adjustments or replacement of the drug should be considered. Details of other drugs should be reported to the doctor.
CyclophosphamideThe desired effect of cyclophosphamide will not be obtained if these drugs are concurrently taken. Under doctor's supervision, appropriate dose adjustments or replacement of the drug should be considered. Details of other drugs should be reported to the doctor.
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Lybrate does not take responsibility for any aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.