What is symptoms of sle and how diagnosed from sle disease. Please tell in detail.
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Hi, Systemic lupus erythematosus (SLE), is a systemic autoimmune disease (or autoimmune connective tissue disease) in which the body?s immune system mistakenly attacks healthy tissue. There are many kinds of lupus. The most common type is systemic lupus erythematosus (SLE), which affects many internal organs in the body. SLE most often harms the heart, joints, skin, lungs, blood vessels, liver, kidneys, and nervous system. The course of the disease is unpredictable, with periods of illness (called flare-ups) alternating with remissions. The cause is believed to be an environmental trigger, which results in a misdirected immune response in people who are genetically susceptible. A normal immune system makes proteins called antibodies that protect against pathogens such as viruses and bacteria. Lupus is characterized by the presence of antibodies directed against a person's own proteins; these are most commonly anti-nuclear antibodies, which are found in nearly all cases. These antibodies lead to inflammation. SLE is one of several diseases known as" the great imitators" because it often mimics or is mistaken for other illnesses.[8] SLE is a classical item in differential diagnosis,[9] because SLE symptoms vary widely and come and go unpredictably. Diagnosis can thus be elusive, with some people having unexplained symptoms of SLE for years. Common initial and chronic complaints include fever, malaise, joint pains, muscle pains, and fatigue. Because these symptoms are so often seen in association with other diseases, these signs and symptoms are not part of the diagnostic criteria for SLE. Females tend to have a greater number of relapses, a low white blood cell count, more arthritis, Raynaud phenomenon, and psychiatric symptoms. Males tend to have more seizures, kidney disease, serositis (inflammation of tissues lining the lungs and heart), skin problems, and peripheral neuropathy. Lab. Tests for diagnosis: Antinuclear antibody (ANA) testing and anti-extractable nuclear antigen (anti-ENA) form the mainstay of serologic testing for SLE. Several techniques are used to detect ANAs. Clinically the most widely used method is indirect immunofluorescence (IF). The pattern of fluorescence suggests the type of antibody present in the people's serum. Direct immunofluorescence can detect deposits of immunoglobulins and complement proteins in the people's skin. There is no cure for SLE. It is mainly treated with immunosuppressants.
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Hello,this is an autoimmune disease occurs when the immune system attacks its own body because it confuses it for something foreign. SLE is also known as discoid lupus or disseminated lupus erythematosus. Although ?lupus? actually includes a number of different diseases, SLE is the most common type of lupus. Symptoms can vary and can change over time. Common symptoms include: severe fatigue painful or swollen joints headaches rash on cheeks and nose called ?butterfly? rash hair loss anemia blood-clotting problems Raynaud?s syndrome (fingers turning white/blue and tingle when cold) There is no one single diagnostic test, these screening tests are being done to diagnose the SLE. 1. blood tests, such as antibody tests and a complete blood count 2. urinalysis 3. chest X-ray
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