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Hi What is the best treatment for disease - aiha ( acute immune haemolytic anaemia?

1 Doctor Answered
Autoimmune hemolytic anemia (aiha) is caused by autoantibody-induced hemolysis (the premature destruction of circulating red blood cells); usually idiopathic, it is also associated with infection, lymphoproliferative disorders, autoimmune diseases, and some drugs hallmark findings include: anemia with elevated reticulocyte count in the absence of blood loss; a positive direct antiglobulin (coombs) test; and spherocytes or rbc aggregates on the peripheral blood smear. Much literature exists regarding the treatment of aiha. Efficacy of treatment depends on the correct diagnosis of either warm- or cold-type aiha. Warm-type aiha is usually a more insidious disease, not treatable by simply removing the underlying cause. First-line therapy for this is usually with corticosteroids, such as prednisolone. Following this, other immunosuppressants are considered, such as rituximab, danazol, cyclophosphamide, azathioprine, or cyclosporine. Cold agglutinin disease is treated by avoiding the cold or sometimes with rituximab. Removal of the underlying cause is also important. Paroxysmal cold hemoglobinuria is treated by removing the underlying cause, such as infection.
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