Hi Sir, I am taking mesacol 400 mg tablets 2-0-1 for the past 4 years as maintenance dose for ulcerative colitis, which I had contracted almost 25 years ago, the maintenance dose for which I am taking is for last 4 years. I am 70 years old and is not on any other medication except covance 50 mg tablets for bp in 1-0-0 dosage. Of late I am getting knee pain on both my legs which the physician says is starting of osteo arthritis. Since I am moderately active with regular morning walks for 1 hour and some mild yoga exercises and is not smoker or alcoholic and I am very regular with my food timings I am constrained to believe that the so called osteo arthritis can be due tomesacol. If so please advise a way to come out of this ailment.